Results 111 to 120 of about 4,460,775 (261)
Identifying Purkinje cells using only their spontaneous simple spike activity
, 2014 Background: We have extended our cerebellar cortical interneuron classification algorithm that uses statistics of spontaneous activity (Ruigrok et al., 2011) to include Purkinje cells.
Ruigrok, Tom +5 more
core +1 more source
Non‐Alzheimer Aβ deposits in the human CNS: Implications with hypoxia and related conditions
Brain Pathology, EarlyView.An Aβ deposit in a non‐Alzheimer's brain from an individual who experienced hypoxia/energy failure. Abstract We recently reported the deposition of Aβ in the frontal cortex of individuals who died of acute coronavirus disease 2019 (COVID‐19), or who did not have COVID‐19 but had respiratory distress, or infants with severe cardiac malformations.
Esma Karlovich +5 more
wiley +1 more source
Development of axon-target specificity of ponto-cerebellar afferents.
PLoS Biology, 2011 The function of neuronal networks relies on selective assembly of synaptic connections during development. We examined how synaptic specificity emerges in the pontocerebellar projection. Analysis of axon-target interactions with correlated light-electron
Anna Kalinovsky +6 more
doaj +1 more source
, 2008 It has been suggested that information in the brain is encoded in temporal spike patterns which are decoded by `Radial Basis Function' (RBF) neurons using time delays and coincidence detection.
Volker Steuber +2 more
core
lnteractions between cerebellar Purkinje cells and their associated astrocytes [PDF]
, 2001 Some neurons, including cerebellar Purkinje cells, are completely ensheathed by astrocytes. When granule cell neurons and functional glia were eliminated from newborn mouse cerebellar cultures by initial exposure to a DNA synthesis inhibitor ...
Seil, F.J.
core
Proteostasis of organelles in aging and disease
The FEBS Journal, EarlyView.Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi +5 more
wiley +1 more source
Cell ReportsSummary: The loss of cerebellar Purkinje cells is a hallmark of neurodegenerative movement disorders, but the mechanisms remain enigmatic. We show that endocytic adaptor protein complex 2 (AP-2) is crucial for Purkinje cell survival. Using mouse genetics,
Marianna Tolve +14 more
doaj +1 more source
Inverse Stochastic Resonance in Cerebellar Purkinje Cells
, 2016 Purkinje neurons play an important role in cerebellar computation since their axons are the only projection from the cerebellar cortex to deeper cerebellar structures.
Anatoly Buchin (3067782) +14 more
core +1 more source
The FEBS Journal, EarlyView.Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi +12 more
wiley +1 more source