Results 171 to 180 of about 10,727,728 (294)

Genomic Prediction and Genome‐Wide Association Analysis of Heat Tolerance for Milk Yield in Buffaloes Using a Reaction Norm Model

Journal of Animal Breeding and Genetics, Volume 143, Issue 2, Page 342-353, March 2026.
ABSTRACT The aim of this study was to evaluate the impact of incorporating genomic information on the estimation of genetic (co)variance components and the accuracy of breeding values for milk yield under varying thermal environments, and to identify SNPs associated with genes that play significant roles in heat tolerance.
Gabriela Stefani, Mário Luiz Santana, Lenira El Faro, Humberto Tonhati   +3 more
wiley   +1 more source

Gene therapy for epilepsy: An emerging, promising approach for a serious neurological disorder

Journal of Internal Medicine, Volume 299, Issue 3, Page 302-327, March 2026.
Abstract Gene therapy is emerging as a groundbreaking strategy for treating epilepsy, offering new hope to patients who do not respond to conventional medications. Despite advancements in anti‐seizure treatments, nearly 30%–40% of individuals with epilepsy continue to experience uncontrolled seizures, highlighting the urgent need for more effective and
Marco Ledri, Merab Kokaia
wiley   +1 more source

Convergent Recruitment of Cerebellar Purkinje Cells by Mechanistically Diverse General Anesthetics. [PDF]

J Neurochem
Utsumi N, Tanaka DH, Nakai A, Inaba S, Nonaka S, Maeda S, Uesaka N.   +6 more
europepmc   +1 more source

Retrograde Inhibition of Presynaptic Calcium Influx by Endogenous Cannabinoids at Excitatory Synapses onto Purkinje Cells

Neuron, 2001
Anatol C. Kreitzer, W. Regehr
semanticscholar   +1 more source

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, Volume 13, Issue 8, 9 February 2026.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Developmental transformations of Purkinje cells tracked by DNA electrokinetic mobility. [PDF]

Cell Rep Methods
Brandenburg C, Crutcher GW, Romanowski AJ, Donofrio SG, Duraine LR, Owusu-Mensah RNA, Cooper BH, Sugihara I, Blatt GJ, Sillitoe RV, Poulopoulos A.   +10 more
europepmc   +1 more source

Resilience to Endoplasmic Reticulum Stress Mitigates Membrane Hyperexcitability Underlying Late Disease Onset in a Murine Model of SCA6

Annals of Neurology, Volume 99, Issue 2, Page 502-522, February 2026.
Objective An enduring puzzle in many inherited neurological disorders is the late onset of symptoms despite expression of function‐impairing mutant protein early in life. We examined the basis for onset of impairment in spinocerebellar ataxia type 6 (SCA6), a canonical late‐onset neurodegenerative ataxia which results from a polyglutamine expansion in ...
Haoran Huang, Taylor L. Charron, Min Fu, Miranda Dunn, Deborah M. Jones, Praveen Kumar, Satoshi Ishishita, Allan‐Hermann Pool, Ashwinikumar Kulkarni, Genevieve Konopka, Vikram G. Shakkottai   +10 more
wiley   +1 more source

The spiny relationship between parallel fibers, climbing fibers, and Purkinje cells. [PDF]

Front Physiol
Masoli S, Rizza MF, Moccia F, D'Angelo E.   +3 more
europepmc   +1 more source

Using cerebellar Purkinje cell models at different levels of abstraction as a read-out mechanism for pattern recognition in a biologically detailed granular layer model [PDF]

, 2019
Davey, Neil, Kadir, Shabnam, Katakura, Ohki, Maex, Reinoud, Steuber, Volker   +4 more
core   +2 more sources

The excitatory synaptic action of climbing fibres on the Purkinje cells of the cerebellum

Journal of Physiology, 1966
J. Eccles, R. Llinás, K. Sasaki
semanticscholar   +1 more source