Results 161 to 170 of about 4,781,201 (273)

Gephyrin Neurological Autoimmunity

Annals of Neurology, Volume 100, Issue 4, Page 781-787, October 2026.
Gephyrin is a postsynaptic scaffold protein essential for inhibitory neurotransmission. Gephyrin‐immunoglobulin G (IgG) was reported, decades ago, in a single case of paraneoplastic stiff‐person‐like syndrome, but its broader clinical relevance remains unknown.
Maria Chiara Pantuliano, Friederike A. Arlt, Naomi Arenson, Irena Dujmovic Basuroski, Divyanshu Dubey, Connie E. Lesnick, John R. Mills, Sean J. Pittock, Anastasia Zekeridou, Michael A. Lane, Andrew McKeon   +10 more
wiley   +1 more source

Impaired Glur2 palmitoylation in cerebellar Purkinje cells of a Friedreich ataxia mouse model. [PDF]

Exp Neurol
Mercado-Ayón E, Coulman J, Lee JY, Lancaster E, Goga E, Asad M, Witze E, Lynch DR.   +7 more
europepmc   +1 more source

Cardiovascular Exercise Drives Neuroprotection in a Mouse Model of Spinocerebellar Ataxia 1 Via Rescue of Aberrant Splicing

Annals of Neurology, Volume 100, Issue 4, Page 850-866, October 2026.
Objective Spinocerebellar ataxia 1 (SCA1) is a fatal hereditary neurodegenerative disorder with no approved therapies, and gene‐targeting strategies have thus far failed in clinical trials. Exercise remains the only intervention shown to provide clinical benefit in patients with spinocerebellar ataxias (SCAs), yet the underlying mechanisms remain ...
Isabel Soto, Michael Bonomo, Brianna S. Nelthrope, Benjamin D. Carr, Emma Palmer, Mariana Sierra, Ilkim Erturk, David Peppercorn, Eleonor Cox, Tiare K. Vasconcellos, Henry L. Paulson, Hannah K. Shorrock, Sharan R. Srinivasan   +12 more
wiley   +1 more source

Inhibition of Cerebellar Dentate Nucleus‐Zona Incerta Glutamatergic Circuit Improves Sleep Disturbances in Chronic Temporal Lobe Epilepsy Model

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Mice with TLE exhibit significant sleep fragmentation and reduced sleep duration, particularly during non‐rapid eye movement sleep. By employing optogenetic and chemogenetic methods to target CDN glutamatergic neurons, we observed a decrease in sleep fragmentation, an increase in overall sleep duration, and an enhancement in sleep quality among TLE ...
Liang Xia, Xuan Wang, Yingchi Zhang, Jianmin Hao, Dan Mi, Changgeng Song, Wen Jiang   +6 more
wiley   +1 more source

HCAR1-mediated lactate signaling modulates motor behavior and regulates spontaneous firing in Purkinje cells. [PDF]

iScience
Binda F, Buscemi L, Gurtner N, Hirt L, Chatton JY.   +4 more
europepmc   +1 more source

Frequency of anti‐neural antibodies and autoimmune epilepsy in focal epilepsy of unknown etiology: An observational study in a Singaporean cohort

Epilepsia Open, Volume 11, Issue 5, Page 1677-1691, October 2026.
Abstract Objective Autoimmune epilepsy (AES) is increasingly recognized as a condition in patients with epilepsy of unknown etiology. Early immunotherapy improves outcomes; however, data on its prevalence and the frequency of anti‐neural/neuronal antibodies in Asian populations remain scarce.
Seong Jin Park, Jeanne May May Tan, Xuejuan Peng, Patricia Yut Wan Wong, Karine Su Shan Tay, Angelia Swee Hoon Koe, Janis Siew Noi Tye, Josiah Yui Huei Chai, Pei Xuan Koh, Yee Leng Tan, Sheila Srinivasan, Ngai Kun Loh, Nigel Choon Kiat Tan, Kevin Tan, Tianrong Yeo   +14 more
wiley   +1 more source

Protocol for sparse labeling of murine Purkinje cells by intracerebroventricular AAV injection using a microelectrode holder. [PDF]

STAR Protoc
Lillibridge JJ, Vancs S, Riccomagno MM, Karginov FV.   +3 more
europepmc   +1 more source

Astrocyte‐enriched and cilia‐related genetic signatures in dementia: A whole‐exome sequencing study

General Psychiatry, Volume 39, Issue 5, October 2026.
ABSTRACT Background Alzheimer's disease (AD), the most prevalent form of dementia, is highly heritable, yet much of its genetic basis remains unexplained. Most genetic studies have focused on European populations, with limited data from under‐represented groups.
Miaohan Deng, Yucan Chen, Lu Zhao, Weichen Song, Qi Qiu, Lin Sun, Xiang Lin, Weidi Wang, Guan Ning Lin, Xia Li   +9 more
wiley   +1 more source

Purkinje Cells in Crus I and II Encode the Visual Stimulus and the Impending Choice as Monkeys Learn a Reinforcement-Based Visuomotor Association Task. [PDF]

J Neurosci
Ipata AE, Fascianelli V, De Zeeuw CI, Sendhilnathan N, Fusi S, Goldberg ME.   +5 more
europepmc   +1 more source

MRI Characterization of Structural Brain Abnormalities in NGLY1 Deficiency

International Journal of Developmental Neuroscience, Volume 86, Issue 6, October 2026.
Structural MRI from 11 patients with NGLY1 deficiency, an ultrarare neurodevelopmental disorder, revealed reduced subcortical volume (thalamus and putamen) across ages and reduced cortical surface area in younger patients. These measures tracked with clinical features such as seizures and gait disturbance, supporting brain imaging as a candidate ...
Emily L. Dennis, Lei Zhu, William F. Mueller, Jennifer W. Cook, Gracie Morrison, Matt Wilsey, Ryan Dant, Selina Dwight, Kevin J. Lee   +8 more
wiley   +1 more source