Results 141 to 150 of about 4,460,775 (261)

Inositol pyrophosphate kinases in health and disease

FEBS Letters, Volume 600, Issue 17, Page 2379-2396, September 2026.
In mammalian cells, IP6Ks and PPIP5Ks are the key kinases synthesizing the inositol pyrophosphates 5PP‐InsP5 and InsP8. They are essential for early development but also mediate age‐related diseases, including metabolic disorders, cardiovascular diseases, neurodegenerative diseases, and cancers.
Changchang Xing, Chao Wang, Yuanyuan Chen, Weiwei Cheng, Zhaolei Jiang, Alex F. Chen, Chenglai Fu   +6 more
wiley   +1 more source

Purkinje cell models

Frontiers in Computational Neuroscience
The investigation of the dynamics of Purkinje cell (PC) activity is crucial to unravel the role of the cerebellum in motor control, learning and cognitive processes. Within the cerebellar cortex (CC), these neurons receive all the incoming sensory and motor information, transform it and generate the entire cerebellar output.
Fernández Santoro, Elías Mateo, Karim, Arun, Warnaar, Pascal, De Zeeuw, Chris I., Badura, Aleksandra, Negrello, Mario   +5 more
openaire   +1 more source

Allele-specific silencing prevents Purkinje cells pathology.

, 2014
Fluorescence microscopy analysis for the DARPP-32 (a,b) and calbindin (c,d) proteins highlighting the Purkinje cells. An increased expression of DARPP-32 neuronal marker was observed for the shAtx3-treated mice, relative to control-treated.
Nicole Déglon (46541), David Albuquerque (275749), Isabel Onofre (275748), Isabel Nascimento-Ferreira (275747), Clévio Nóbrega (275746), Luís Pereira de Almeida (221526)   +5 more
core   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, Volume 13, Issue 51, 14 September 2026.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Highly restricted expression of Cre recombinase in cerebellar Purkinje cells

, 2004
The Purkinje neuron, one of the most fascinating components of the cerebellar cortex, is involved in motor learning, motor coordination, and cognitive function.
Huang, JD, Wu, WT, Copeland, NG, Jenkins, NA, Ng, AHL, Zhang, XM, Tanner, JA   +6 more
core   +1 more source

Evaluation of the Expression and Prognosis of Neural‐Related Products Expressed by Cancer‐Derived Mesenchymal Stem Cells With the Characteristics of Neural Stem Cells

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Studies have demonstrated that the nervous system plays an important role in cancer progression. Nevertheless, the effect of mesenchymal stem cells (MSCs) on cancer has yielded conflicting results. In this study, we discovered that cancer‐derived MSCs (CA‐MSCs) not only exhibit the properties of neural stem cells (NSCs) but also express a ...
Liu Yongjun, Pan Zhiwen, Fu Shangui, Zhai Jinjie, Ying Rongbiao, Chen Zhongjian, Chen Wanyuan, Ju Haixing, Ma Dening, Long Dan, Luo Cong, Fu Zhixuan   +11 more
wiley   +1 more source

The Molecular Architecture of Somatic Spines of the Lateral Septum

Journal of Comparative Neurology, Volume 534, Issue 9, September 2026.
Spine synapses represent stable synaptic connections that allow neurons to chemically communicate with each other. Although known for decades, the unusual spine synapses found directly on neuronal cell bodies in the lateral septum have not been characterised in detail.
Daniela Hacker, Erich Weisheim, Michaela Schweizer, Undine Schneeweiß, Maximilian Borgmeyer, Michael Brecht, Marina Mikhaylova   +6 more
wiley   +1 more source

A role of secretin in postnatal development of purkinje cells

, 2017
Postnatal development of Purkinje cells is one of the fundamental cellular events involved in the coordinated cerebellar development and has been implicated in the pathogenesis of psychiatric disorders.
WANG, L, Zhang, LI, Chow, BKC
core  

The segregation of Calb1, Calb2, and Prph neurons reveals distinct and mixed neuronal populations and projections to hair cells in the inner ear and central nuclei

Developmental Dynamics, Volume 255, Issue 9, Page 845-866, September 2026.
Three populations of hair cells have a distinct expression of Calb1 and Calb2. (A, A′D) The central is highly positive for Calb1 while surrounding HC are positive for Calb2. Later, a calyx forms primarily with Calb1. (B, B′, D′, D″) Saccule and utricle start out positive for Calb2 but will upregulate the Calb1 in the striola that is primarily forming ...
Jeong Han Lee, Ebenezer N. Yamoah, Jennifer Kersigo, Karen Elliott, Niya LaRoda, Gabriela Pavlinkova, Bernd Fritzsch   +6 more
wiley   +1 more source

From regulatory mechanisms to cutting‐edge applications: Research progress of ultrasound, electrical, magnetic, and optical stimulation in neural modulation

Journal of Intelligent Medicine, Volume 3, Issue 3, Page 196-219, September 2026.
Abstract In recent years, the clinical treatment and symptom management of neurological disorders have faced significant challenges due to the high complexity of the nervous system's structure and function. Against this backdrop, physical stimulation techniques have emerged as a vital complementary approach to traditional pharmacological treatments and
Wanying Li, Liqun Chen
wiley   +1 more source