Results 151 to 160 of about 4,781,201 (273)
Advanced Science, Volume 13, Issue 56, 9 October 2026.scTIDE identifies single‐cell tipping points by combining manifold‐based graph representations with optimal‐transport conditional flow matching, which preserves intrinsic topology and models distributional dynamics. It supports critical‐transition detection at individual‐cell resolution, prediction of unseen cells, and dimensionality reduction and ...
Jiayuan Zhong +6 more
wiley +1 more source
Advanced Science, Volume 13, Issue 57, 14 October 2026.HD‐tDCS promotes recovery after intracerebral hemorrhage by enhancing PPARγ‐dependent astrocyte remodeling in a mouse model of ICH. This process suppresses proinflammatory astrocytic activation, restores perivascular AQP4 repolarization, and improves glymphatic influx and efflux, thereby facilitating hematoma and perihematomal edema clearance and ...
Zhiming Li +8 more
wiley +1 more source
In this note, the author provides a surprising path to potentially validating the ephaptic coupling model presented in the author’s doctoral dissertation and showing its predictive potential.
openaire +2 more sources
PURKINJE CELLS: STRUCTURE, FUNCTION, DEVELOPMENT, AND CLINICAL SIGNIFICANCE
Purkinje cells are specialized neurons located exclusively within the cerebellar cortex. They are distinguished by their expansive, intricately branched, planar dendritic arbors, which enable them to integrate vast amounts of information and adapt ...
Murotov, Oblokul
core +1 more source
Advanced Science, Volume 13, Issue 58, 19 October 2026.Primary cultures of neuroblasts isolated from the nucleus basalis of Meynert of 12‐weeks‐old human foetuses were prepared. Whole‐cell patch‐clamp recordings were performed by injecting a depolarizing stimulus current (+500 pA; 500 ms), and the membrane voltage recorded; this stimulus current evoked periodic‐like oscillations in membrane voltage ...
Elisabetta Coppi +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 58, 19 October 2026.Frontal lobe traumatic brain injury is associated with hyperactivity of an insular–orbitofrontal circuit in both patients and mice. By combination of integrating functional imaging, cell‐type–specific circuit manipulation, single‐cell transcriptomics, and whole‐cell recordings, this work identifies the downregulation of the potassium channel KCNC3 in ...
Meng‐Ge Li +10 more
wiley +1 more source
Advanced Science, Volume 13, Issue 58, 19 October 2026.This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su +9 more
wiley +1 more source
Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1964-1981, October 2026.Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou +4 more
wiley +1 more source
Physical Activity and Purkinje Cells: Mechanisms of Cerebellar Plasticity and Neuroprotection. [PDF]
J Funct Morphol KinesiolPalmeri N +6 more
europepmc +1 more source