Results 151 to 160 of about 12,043,245 (295)
Abstract Background and Purpose Human induced pluripotent stem cell‐derived cardiomyocytes (hiPSC‐CM) have gained interest as a pharmacological model but their immaturity leads to uncertainty regarding translation. We studied the key player in maintaining ionic homeostasis, the Na+/K+‐ATPase (NKA), in hiPSC‐CM.
Djemail Ismaili +16 more
wiley +1 more source
The role of lipid metabolism in neuronal senescence
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari +2 more
wiley +1 more source
Temporal learning in the cerebellum: The microcircuit model [PDF]
The cerebellum is that part of the brain which coordinates motor reflex behavior. To perform effectively, it must learn to generate specific motor commands at the proper times.
Miles, Coe F., Rogers, David
core +1 more source
Memory trace and timing mechanism localized to cerebellar Purkinje cells
F. Johansson +4 more
semanticscholar +1 more source
Hominoid‐specific calretinin‐immunopositivity of the optic radiation (geniculocalcarine tract)
Calretinin‐immunostained coronal section through the primary (V1) and extrastriate (ExSt) cortex of the lar gibbon. Note that the optic radiation (OR) is strongly calretinin‐immunoreactive. This calretinin‐immunopositivity of the OR distinguishes the Hominoidea from other primates in terms of the neurochemistry of the OR.
Nelyane N. M. Santana +5 more
wiley +1 more source
Mutation in RNF170 Causes Unsteady Gait with Hypertrophic Olivary Degeneration
ABSTRACT Hypertrophic olivary degeneration (HOD) is a rare form of transsynaptic degeneration resulting from disruption of the Guillain–Mollaret triangle, typically presenting with palatal tremor, ataxia, and nystagmus. Mutations in the Ring Finger Protein 170 (RNF170) gene have been associated with autosomal dominant sensory ataxia.
Change Wang
wiley +1 more source
Ultra-rapid axon-axon ephaptic inhibition of cerebellar Purkinje cells by the pinceau
Antonin Blot, B. Barbour
semanticscholar +1 more source
We investigated neuropathological manifestations of hypothermia in 168 cases. Patients aged 65 years or more constituted 80% of the total cohort. Alzheimer's disease was the most common comorbidity, affecting 40% of all patients. Abstract There is a paucity of autopsy‐based studies providing detailed neuropathological characteristics of fatal ...
Shojiro Ichimata +2 more
wiley +1 more source

