Results 151 to 160 of about 4,460,775 (261)
Mitochondrial CLPP in Health and Disease: Mechanisms, Therapeutic Duality and Emerging Opportunities
Journal of Inherited Metabolic Disease, Volume 49, Issue 5, September 2026.The graphical abstract illustrates the context‐dependent therapeutic modulation of CLPP. Pharmacological CLPP activation has reached clinical application in cancer (black arrow), whereas reduced CLPP activity has shown beneficial effects experimentally in models of primary mitochondrial disease and metabolic syndrome, as well as cancer (grey arrows ...
Lea Isermann, Aleksandra Trifunovic
wiley +1 more source
MedComm, Volume 7, Issue 9, September 2026.Mitochondria is the hub of apoptosis in various diseases. The disruption of mitochondrial structure (including membrane rupture, cristae remodeling, and mitochondrial membrane lipid redistribution), the imbalance of mitochondrial dynamics (including fusion and fission, autophagy), the release, disruption, and mutation of mitochondria DNA, as well as ...
Rubin Tan +9 more
wiley +1 more source
Advances in FGF/FGFR Signaling: Implications for Disease and Therapy
MedComm, Volume 7, Issue 9, September 2026.The FGF/FGFR signaling is indispensable for the maintenance of physiological homeostasis and governs multiple biological processes, including embryonic development, bone metabolism, angiogenesis, and neurogenesis, whereas aberrant hyperactivation of this pathway drives the progression of malignancies and autoimmune disorders, including inflammatory ...
Miaoyu Song +4 more
wiley +1 more source
In this note, the author provides a surprising path to potentially validating the ephaptic coupling model presented in the author’s doctoral dissertation and showing its predictive potential.
openaire +2 more sources
Proteomic Remodeling in the Failing Left Ventricle Adapting to Dyssynchrony
PROTEOMICS – Clinical Applications, Volume 20, Issue 5, September 2026.ABSTRACT Purpose In heart failure, dyssynchrony is associated with accelerated cardiac remodeling and a worse prognosis. Both restored with resynchronization. We have previously developed a mouse model of dyssynchrony and resynchronization and here assess changes in protein expression within that model.
Karin Ljung +4 more
wiley +1 more source
Attenuation of DOX‐Associated Biochemical and Histological Brain Alterations
Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.This research highlights the need for practical methods to lessen the neurotoxicity caused by doxorubicin. ABSTRACT Background Doxorubicin (DOX) is a common anticancer drug used to treat various types of neoplasms. However, its use is associated with neurotoxic effects, including neuronal degeneration and damage.
Ehab Y. Abdelhiee +11 more
wiley +1 more source
Aging Cell, Volume 25, Issue 9, September 2026.Neuronal senescence‐like states arise from convergent intrinsic and disease‐associated stressors and are linked to persistent dysfunction, SASP‐like signaling, and altered glial interactions. Because no single marker is definitive in post‐mitotic neurons, multimarker and context‐dependent frameworks are required to define their role in ...
Miraj Ud Din Momand +2 more
wiley +1 more source
The oscillatory response of the electroretinogram and neuronal adaptation
Acta Ophthalmologica, Volume 104, Issue 6, Page 616-637, September 2026.Abstract After more than 50 years, there still remains a challenge and an interest to know more as well as extend and deepen our understanding of the small rapid wavelets, the oscillatory potentials (OPs), of the electroretinogram (ERG) and the neuronal adaptation of the retina.
Lillemor Wachtmeister, Anders Eklund
wiley +1 more source
Physical Activity and Purkinje Cells: Mechanisms of Cerebellar Plasticity and Neuroprotection. [PDF]
J Funct Morphol KinesiolPalmeri N +6 more
europepmc +1 more source