Results 171 to 180 of about 4,781,201 (273)

Increased Ca²⁺ Sequestration by the Sarco-/Endoplasmic Reticulum in Cardiac Purkinje Cells After Myocardial Infarction. [PDF]

Cells
Amin R, Hopkinson Z, Wiede L, Haq KT, Boyden PA, Ter Keurs HEDJ, Stuyvers BD.   +6 more
europepmc   +1 more source

Cardiac Resynchronization as an Enabler of ARNI Efficacy: Insights From a Real‐World Cohort

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
CRT provides the mechanical substrate that enables sacubitril/valsartan to maximize reverse remodeling. In this real‐world cohort, ARNI therapy was associated with greater improvement in left ventricular function and fewer clinically validated device‐detected HF events, particularly among CRT responders, supporting a synergistic interaction between ...
Amato Santoro, Laura Spaccaterra, Maurizio Collantoni, Claudia Baiocchi, Benedetta Maria Natali, Stefano Lunghetti, Antonio Pagliaro, Niccolò Manetti, Francesco Morrone, Massimo Fineschi, Alberto Palazzuoli   +10 more
wiley   +1 more source

Loss of YY1 in Purkinje cells triggers cerebellar ataxia via Wnt10b-mediated impairment of dendrite development. [PDF]

iScience
Lui YL, Dong X, Leung TCN, Li TH, Chan TF, Kwan KM.   +5 more
europepmc   +1 more source

Conduction System Pacing Versus Biventricular Pacing for Cardiac Resynchronization Therapy: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

Journal of Arrhythmia, Volume 42, Issue 5, October 2026.
Current randomized evidence does not demonstrate statistically significant superiority of CSP over BVP for CRT. Exploratory analyses suggest benefit may be greatest among patients with true LBBB receiving dedicated LBBAP/LBBP. ABSTRACT Background Conduction system pacing (CSP) is an emerging alternative to biventricular pacing (BVP) for cardiac ...
Shreyas Singireddy, Sami Shoura, Darshine Venugopal, Ragavendar Saravanabavanandan, Kyle Coombes, Timir Baman, Siddharth Shah   +6 more
wiley   +1 more source

NMDA and glycine receptors provide dual presynaptic regulation on climbing fibre inputs to cerebellar Purkinje cells. [PDF]

J Physiol
Benton DCH, Robertson AD, Caldwell M, Pankratov Y, Imam L, Smart TG, Morris G, Moss GWJ.   +7 more
europepmc   +1 more source

Neuropathic Pain: From Mechanisms to Therapeutic Interventions

MedComm, Volume 7, Issue 10, October 2026.
Neuropathic pain arises from peripheral nerve injury, central sensitization, neurotransmitter imbalance, neuroimmune activation, and maladaptive circuit remodeling. Clinical phenotyping and multimodal imaging can identify dominant peripheral and central mechanisms.
Yaling Dai, Mengquan Tan, Man Yuan, Huixian Zhou, Qin Xie, Jiling Zeng, Yixin Yang, Xinran He, Siyuan Song   +8 more
wiley   +1 more source

Voluntary running reduces loss of PTEN-deficient Purkinje cells, modulates their metabolic signaling, and improves motor deficits in mice. [PDF]

Front Cell Neurosci
Brazier SR, Ditrano KL, Betancourt-Trompa DS, Belt GA, Barbarini OR, Pena UM, Espinal-San Miguel IM, Rodriguez AV, Immerman CN, Petrelli CJ, Dennett RR, Reddy R, Greenspan DJ, Walsh LJ, Enestvedt C, Bridges CM, Snodgrass-Belt PA, Soto I.   +17 more
europepmc   +1 more source

Precision Medicine in Neurodegeneration with Brain Iron Accumulation (NBIA) Disorders: An Update on Emerging Treatments

Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2405-2418, October 2026.
Abstract Background Neurodegeneration with Brain Iron Accumulation (NBIA) is a heterogeneous group of heritable, mostly recessive, progressive neurodegenerative diseases characterized by iron deposition in the basal ganglia and brainstem. There are no solid global epidemiological data on prevalence and incidence of NBIA subtypes, but registry data and ...
Susanne A. Schneider, Divyani Garg, Vassilena Iankova, Thomas Klopstock   +3 more
wiley   +1 more source

Driving Cerebellar Theta Oscillations Interferes With Voluntary Neck Movements in Cervical Dystonia

Movement Disorders, Volume 41, Issue 10, Page 2688-2698, October 2026.
Abstract Background Cervical dystonia (CD) is a movement disorder with a complex pathophysiology, including cerebellar abnormalities. Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique capable of entraining brain oscillations, can transiently modulate neuronal activity and enhance resonant rhythms.
Davide Costa, Andrea Guerra, Daniele Birreci, Massimiliano Passaretti, Martina De Riggi, Anna Sofia Grandolfo, Valentina D'Onofrio, Luca Angelini, Giulia Paparella, Matteo Bologna   +9 more
wiley   +1 more source

Convergent Recruitment of Cerebellar Purkinje Cells by Mechanistically Diverse General Anesthetics. [PDF]

J Neurochem
Utsumi N, Tanaka DH, Nakai A, Inaba S, Nonaka S, Maeda S, Uesaka N.   +6 more
europepmc   +1 more source