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Heterotopic Purkinje cells in ataxia‐telangiectasia
Neuropathology, 2011Ataxia‐telangiectasia (A‐T) is a heritable disorder of cerebellar ataxia and oculocutaneous telangiectasias caused by mutation of the ATM gene. The most prominent and consistent neuropathologic finding in the disorder is cerebellar cortical degeneration involving significant loss of granule and Purkinje cells.
Alexander R, Bottini +3 more
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Selective sensitivity of the Purkinje cells of the cerebellum
The American Journal of Medicine, 1954Abstract A non-progressive parenchymatous cerebellar syndrome following abruptly upon an episode of hyperpyrexia is described. The relevant literature is reviewed and the syndrome is differentiated from progressive parenchymatous cerebellar degeneration.
D A, FREEDMAN, J C, ROURKE
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Neuroscience Gateway, 2006
Compromised glutamate transport in Bergmann glia contributes to Purkinje cell death in a model of spinal cerebellar ataxia.
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Compromised glutamate transport in Bergmann glia contributes to Purkinje cell death in a model of spinal cerebellar ataxia.
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Purkinje Cells and their Responses
1967In Chapter I there is an extensive account of the structural features of the most remarkable elements of the cerebellar cortex, the Purkinje cells, and in Chapter III there is a full description of the synapses that parallel fibers make with the spiny branchlets of Purkinje cell dendrites.
John C. Eccles +2 more
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Gravity responses of Purkinje cells in the nodulus
Experimental Brain Research, 1976In cats, either decerebrated or under chloralose anaesthesia, Purkinje cells (P-cells) of the cerebellar nodulus have been examined with the animal under static lateral tilt (roll +/- 20 degrees). The cell activity was extracellularly recorded and both "simple" and "complex" spike discharge patterns were studied. In 20 cells out of a population of 198,
G, Marini, L, Provini, A, Rosina
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1992
We present a mathematical/computer model of a Purkinje cell. The model is a binary dendritic tree of Rall compartments connected to trunk, soma and then Hodgkin-Huxley axon. We perform studies of the model for different parameters, especially those provided by Shelton, and Pellionisz and Linas.
E. K. Blum, Xin Wang
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We present a mathematical/computer model of a Purkinje cell. The model is a binary dendritic tree of Rall compartments connected to trunk, soma and then Hodgkin-Huxley axon. We perform studies of the model for different parameters, especially those provided by Shelton, and Pellionisz and Linas.
E. K. Blum, Xin Wang
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A computer model of cerebellar purkinje cells
Neuroscience, 1977Abstract A mathematical computer model of frog Purkinje cells is generated on the basis of presentday morphological and physiological data. The model utilizes passive cable equations and the Hodgkin & Huxley equations describing ionic conductances in excitable membranes.
A, Pellionisz, R, Llinás
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Patterned Purkinje cell death in the cerebellum
Progress in Neurobiology, 2003The object of this review is to assemble much of the literature concerning Purkinje cell death in cerebellar pathology and to relate this to what is now known about the complex topography of the cerebellar cortex. A brief introduction to Purkinje cells, and their regionalization is provided, and then the data on Purkinje cell death in mouse models and,
Justyna R, Sarna, Richard, Hawkes
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