Results 81 to 90 of about 10,727,728 (294)

Predictive and Feedback Performance Errors Are Signaled in the Simple Spike Discharge of Individual Purkinje Cells

Journal of Neuroscience, 2012
The cerebellum has been implicated in processing motor errors required for on-line control of movement and motor learning. The dominant view is that Purkinje cell complex spike discharge signals motor errors.
Laurentiu S. Popa, A. Hewitt, T. Ebner
semanticscholar   +1 more source

Transparent Transfer‐Free Ultrasmall Multilayer Graphene Microelectrodes Enable High Quality Recordings in Brain Slices

Advanced Science, EarlyView.
A transfer‐free fabrication method enables multilayer graphene microelectrodes as small as 10 µm, eliminating reliability issues of manual graphene transfer. These electrodes record neural activity in brain slices with exceptional signal‐to‐noise ratios (up to 25–40 dB) while maintaining optical transparency for multimodal applications.
Nerea de Alvarez de Eulate, Christos Pavlou, Gonzalo León González, María Camarena Pérez, Lukas Holzapfel, Zhenyu Gao, Sten Vollebregt, Vasiliki Giagka   +7 more
wiley   +1 more source

Cerebellar Learning in an Opponent Motor Controller for Adaptive Load Compensation and Synergy Formation [PDF]

, 1993
This paper shows how a minimal neural network model of the cerebellum may be embedded within a sensory-neuro-muscular control system that mimics known anatomy and physiology.
Bullock, Daniel, Contreras-Vidal, Jose L., Grossberg, Stephen   +2 more
core   +1 more source

Climbing fiber regulation of spontaneous Purkinje cell activity and cerebellum-dependent blink responses [PDF]

, 2016
It has been known for a long time that GABAergic Purkinje cells in the cerebellar cortex, as well as their target neurons in the cerebellar nuclei, are spontaneously active.
Bengtsson, F. (Fredrik), Rasmussen, A. (Anders), Zucca, R. (Riccardo)   +2 more
core   +3 more sources

Purkinje cell stripes and long-term depression at the parallel fiber-Purkinje cell synapse [PDF]

Frontiers in Systems Neuroscience, 2014
Article deposited according to Frontiers policy for Frontiers in Systems Neuroscience: http://www.frontiersin.org/about/faq June 18 ...
openaire   +4 more sources

SAGE: Spatially Aware Gene Selection and Dual‐View Embedding Fusion for Domain Identification in Spatial Transcriptomics

Advanced Science, EarlyView.
SAGE is a unified framework for spatial domain identification in spatial transcriptomics that jointly models tissue architecture and gene programs. Topic‐driven gene selection (NMF plus classifier‐based scoring) highlights spatially informative genes, while dual‐view graph embedding fuses local expression and non‐local functional relations.
Yi He, Yunpei Xu, Liqing Ding, Hong‐Dong Li, Yaohang Li, Shaokai Wang   +5 more
wiley   +1 more source

Altered Dendritic Morphology of Purkinje cells in Dyt1 ΔGAG Knock-In and Purkinje Cell-Specific Dyt1 Conditional Knockout Mice

PLoS ONE, 2011
Background DYT1 early-onset generalized dystonia is a neurological movement disorder characterized by involuntary muscle contractions. It is caused by a trinucleotide deletion of a GAG (ΔGAG) in the DYT1 (TOR1A) gene encoding torsinA; the mouse homolog ...
Lin Zhang, F. Yokoi, Yuan-Hu Jin, M. DeAndrade, K. Hashimoto, D. Standaert, Yuqing Li   +6 more
semanticscholar   +1 more source

A Novel Gain‐of‐Function ITPR1 Variant Associated With a Movement Disorder Characterized by Tremor and Dystonia

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The 1,4,5‐trisphosphate receptor type 1 (ITPR1) gene encodes an endoplasmic reticulum calcium release channel, in which loss‐of‐function mutations have been associated with spinocerebellar ataxias and related neurological phenotypes. Only one gain‐of‐function mutation in the highly conserved suppressor domain of ITPR1 has been previously ...
Emilie T. Théberge, Bo Sun, Ruiwu Wang, Arezoo Mohajeri, Clara D. M. Van Karnebeek, Cornelius F. Boerkoel, Stephanie Huynh, Gabriella Horvath, S. R. Wayne Chen, Anna Lehman   +9 more
wiley   +1 more source

Attentive Learning of Sequential Handwriting Movements: A Neural Network Model [PDF]

, 2000
Defense Advanced research Projects Agency and the Office of Naval Research (N00014-95-1-0409, N00014-92-J-1309); National Science Foundation (IRI-97-20333); National Institutes of Health (I-R29-DC02952-01)
A. Berardelli, A. Dagher, A. Thomassen, A. Thomassen, A.B. Schwartz, A.P. Georgopoulos, A.P. Georgopoulos, A.P. Georgopoulos, A.P. Georgopoulos, A.W. Gemmert van, B.D. Kretschmer, C. Fowler, C. Ghez, C.E. Wright, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Bullock, D. Ostry, D. Zipser, D.M. Bannerman, D.V. Buonomano, E. Bizzi, E.M. Arroyo-Anllo, F. Chapeau-Blondeau, F. Lacquaniti, F. Mussa-Ivaldi, F. Richer, F.B. Horak, F.B. Horak, F.N. Freeman, G.P. Galen van, G.P. Galen van, G.T. Bartha, I. Hertrich, J. Alston, J. Doyon, J. Fiala, J. Schillings, J. Soechting, J. Wann, J.A. Freeman, J.B. Hopfinger, J.D. Coltz, J.D. Coltz, J.F. Kalaska, J.I. Simpson, J.J. Waite, J.M. Hollerbach, J.P. Wann, J.W. Moore, K. Greer, M. Hallett, M. Iacoboni, M. Ito, M. Ito, M. Ito, M. Jueptner, M. Jueptner, M. Jueptner, M.G. Pleskacheva, M.T. Turvey, N. Bernstein, N. Sadato, O. Oscarsson, P. Morasso, P. Morasso, P. Morasso, P. Vindras, P.C. Burns, Q.G. Fu, R. Andersen, R. Andersen, R. Caminiti, R. Gellman, R. Kawashima, R. Plamondon, R.S. Turner, R.S. Turner, S. Chieffi, S. Edelman, S. Grossberg, S. Grossberg, S. Grossberg, S. Jaffe, S. Ohman, S.P. Perrett, T.J. Ebner, T.L. Zhou, T.S. Buchanan, W. Abend, X. Lu   +93 more
core   +2 more sources

Fusion between human mesenchymal stem cells and rodent cerebellar Purkinje cells

Neuropathology and Applied Neurobiology, 2011
K. Kemp, D. Gordon, D. C. Wraith, E. Mallam, E. Hartfield, J. Uney, A. Wilkins and N. Scolding (2011) Neuropathology and Applied Neurobiology37, 166–178
Fusion between human mesenchymal stem cells and rodent cerebellar Purkinje ...
K. Kemp, David Gordon, D. Wraith, E. Mallam, EM Hartfield, J. Uney, A. Wilkins, Neil J Scolding   +7 more
semanticscholar   +1 more source