Results 221 to 230 of about 6,259 (281)

The Emerging Role of Peroxisome Proliferator-Activated Receptors in Cancer Stemness. [PDF]

Cells
Parejo-Alonso B, Mascaraque M, Royo-García A, Sancho P.   +3 more
europepmc   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

Adaptive immunotherapeutic paradigms in diffuse midline glioma: integrating epigenetic reprogramming, neuron-glioma interactions, and tumor microenvironment modulation. [PDF]

J Neurooncol
Liu J, Ha JH, Abikenari M, Sjoholm MA, Annagiri S, Ravi K, Bergsneider BH, Verma R, Theodros D, Medikonda R, Li G, Prolo LM, Monje M, Lim M.   +13 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

An Ecological and Neural Argument for Developing Pursuit-Based Cognitive Enrichment for Sea Lions in Human Care. [PDF]

Animals (Basel)
Cook PF, Reichmuth C.
europepmc   +1 more source

Rewiring tumor visibility: The immunopeptidome as a dynamic interface between antigen processing, microenvironmental stress, and immune recognition. [PDF]

Front Oncol
Zhao K, Huang Y, Chang L, Wang B, Ye M, Qi J.   +5 more
europepmc   +1 more source

Engineering combination nanomedicines to overcome cancer resistance. [PDF]

RSC Adv
Singh H, Balusamy SR, Sukweenadhi J, Shrivastav A, Mohanprasanth A, Saravanan M, Mijakovic I, Singh P.   +7 more
europepmc   +1 more source

Revisiting the streptococcal M protein: modern perspectives on antibody function, host interactions, and therapeutic targeting. [PDF]

Front Immunol
Wrighton S, Nordenfelt P.
europepmc   +1 more source

Nipah Virus in Focus: A Comprehensive Review of the Pathogenesis, Epidemiological Patterns, Diagnostic Advances, and Future Public Health Strategies. [PDF]

Cureus
Gurajala S, Gurajala SS.
europepmc   +1 more source