Results 201 to 210 of about 1,951 (305)

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

open access: yesBritish Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes   +7 more
wiley   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Accountability and Hyperaccountability in Child Protection Scandals

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT The number of child abuse–related deaths has decreased significantly in the United Kingdom over the past 50 years, but there remains public and political concern about the actual and perceived risk of child deaths, with resultant processes enacted to supervise child protection practice.
Robin Sen, John Devaney
wiley   +1 more source

Safety Assessment in Child Protection—A Survey Study With Dutch Child Protection Workers

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT Safety assessment is a crucial part of child protective services to estimate acute and chronic danger in families that are at risk for child abuse in order to determine whether and which steps need to be taken to protect the child's safety. This study aimed to gain insight into the usefulness of the safety assessment procedure at Dutch child ...
B. Erens, H. Gerger, E. Simon
wiley   +1 more source

Financially Coerced ‘Self‐Produced’ Child Sexual Exploitation Material: Narratives of Accountability

open access: yesChild &Family Social Work, EarlyView.
ABSTRACT Perpetrators financially coerce children to ‘self‐produce’ child sexual exploitation material (CSEM). A harmful dominant narrative has historically blamed victims by framing this form of child sexual exploitation as ‘children engaging in sex work’ obfuscating the tactics of perpetrators.
Genevieve Bloxsom   +4 more
wiley   +1 more source

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