Results 81 to 90 of about 883 (101)
Trub1-mediated pseudouridylation is dispensable for immune cell development and homeostasis. [PDF]
Genes ImmunMalviya V +10 more
europepmc +1 more source
Targeting PUS7 suppresses tRNA pseudouridylation and glioblastoma tumorigenesis
Nature Cancer, 2021 Pseudouridine is the most frequent epitranscriptomic modification. However, its cellular functions remain largely unknown. Here, we show that pseudouridine synthase 7 (PUS7) is highly expressed in glioblastoma versus normal brain tissues, and high PUS7 expression levels are associated with worse survival in patients with glioblastoma.
Haowei Meng, Behnam Badie, Yanhong Shi
exaly +4 more sources
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PUS7: a targetable epitranscriptomic regulator of glioblastoma growth
Trends in Pharmacological Sciences, 2021Pseudouridine is the most abundant yet unexplored RNA modification in glioblastoma. Cui and coworkers find that PUS7, a pseudouridine depositing enzyme, promotes tumor growth and can be targeted by small molecule inhibitors. Mechanistically, PUS7 modifies tRNAs, reduces TYK2 translation, and downregulates a proliferation-restricting interferon-STAT1 ...
Guo-Li Ming +2 more
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The human pseudouridine synthase PUS7 recognizes RNA with an extended multi-domain binding surface [PDF]
Nucleic Acids Research, 2021 Abstract The human pseudouridine synthase PUS7 is a versatile RNA modification enzyme targeting many RNAs thereby playing a critical role in development and brain function. Whereas all target RNAs of PUS7 share a consensus sequence, additional recognition elements are likely required, and the structural basis for RNA binding by PUS7 is ...
Ute Kothe +2 more
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PUS7 mutations impair pseudouridylation in humans and cause intellectual disability and microcephaly
Human Genetics, 2019 Pseudouridylation is the most common post-transcriptional modification, wherein uridine is isomerized into 5-ribosyluracil (pseudouridine, Ψ). The resulting increase in base stacking and creation of additional hydrogen bonds are thought to enhance RNA stability.
Inas S M Sayed +2 more
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Molecular Genetics and Metabolism, 2022
Protein translation is a highly regulated process involving the interaction of numerous genes on every component of the protein translation machinery. Upregulated protein translation is a hallmark of cancer and is implicated in autism spectrum disorder, but the risks of developing each disease do not appear to be correlated with one another.
William A Gahl +2 more
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Protein translation is a highly regulated process involving the interaction of numerous genes on every component of the protein translation machinery. Upregulated protein translation is a hallmark of cancer and is implicated in autism spectrum disorder, but the risks of developing each disease do not appear to be correlated with one another.
William A Gahl +2 more
exaly +3 more sources
Biochemical insight into pseudouridine synthase 7 (PUS7) as a novel interactor of sirtuin, SIRT1
Biochemical and Biophysical Research Communications, 2019Sirtuin1 (SIRT1) forms a dynamic regulatory network with multiple proteins. The SIRT1 protein interactome comprises histone, non-histone substrates, and modulators of SIRT1 deacetylase. Proteomic studies have enlisted several proteins in SIRT1 network, but the structural and functional details of their interactions remain largely unexplored.
Padmanabhan Balasundaram +2 more
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PUS7 promotes the progression of pancreatic cancer by interacting ANLN to activate MYC pathway
Molecular and Cellular BiochemistryTo investigate the role of pseudouridine synthase 7 (PUS7) in pancreatic cancer (PC) and explore its underlying molecular mechanisms. PUS7 role in the malignant biological function of PC cells was investigated by colony formation, EdU, flow cytometry, and transwell assays.
Jingtao Zhong
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Variants in PUS7 Cause Intellectual Disability with Speech Delay, Microcephaly, Short Stature, and Aggressive Behavior [PDF]
American Journal of Human Genetics, 2018 We describe six persons from three families with three homozygous protein truncating variants in PUS7: c.89_90del (p.Thr30Lysfs∗20), c.1348C>T (p.Arg450∗), and a deletion of the penultimate exon 15. All these individuals have intellectual disability with speech delay, short stature, microcephaly, and aggressive behavior.
Christopher A. Powell, Michał Mińczuk
exaly +5 more sources
Molecular Carcinogenesis, 2022
AbstractPseudouridine synthase 7 (PUS7) may play key roles in cancer development. However, few studies have been conducted in this area. In the present study, we explored the function and potential mechanisms of PUS7 in colorectal cancer (CRC) progression. We found that PUS7 had higher expression in CRC tissues and cell lines.
Qi, Zhang +6 more
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AbstractPseudouridine synthase 7 (PUS7) may play key roles in cancer development. However, few studies have been conducted in this area. In the present study, we explored the function and potential mechanisms of PUS7 in colorectal cancer (CRC) progression. We found that PUS7 had higher expression in CRC tissues and cell lines.
Qi, Zhang +6 more
openaire +2 more sources