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Phylogeography of Puumala orthohantavirus in Europe. [PDF]

Viruses, 2019
Puumala virus is an RNA virus hosted by the bank vole (Myodes glareolus) and is today present in most European countries. Whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, Puumala virus (PUUV) evolutionary ...
Castel G, Chevenet F, Razzauti M, Murri S, Marianneau P, Cosson JF, Tordo N, Plyusnin A.   +7 more
europepmc   +17 more sources

Increased Heparanase Levels in Urine during Acute Puumala Orthohantavirus Infection Are Associated with Disease Severity. [PDF]

Viruses, 2022
Old–world orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS), characterized by acute kidney injury (AKI) with transient proteinuria. It seems plausible that proteinuria during acute HFRS is mediated by the disruption of the glomerular ...
Cabrera LE, Schmotz C, Saleem MA, Lehtonen S, Vapalahti O, Vaheri A, Mäkelä S, Mustonen J, Strandin T.   +8 more
europepmc   +18 more sources

Cluster of human Puumala orthohantavirus infections due to indoor exposure?-An interdisciplinary outbreak investigation. [PDF]

Zoonoses Public Health, 2022
Puumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics
Princk C, Drewes S, Meyer-Schlinkmann KM, Saathoff M, Binder F, Freise J, Tenner B, Weiss S, Hofmann J, Esser J, Runge M, Jacob J, Ulrich RG, Dreesman J.   +13 more
europepmc   +12 more sources

Isolation and Genetic Characterization of Puumala Orthohantavirus Strains from France. [PDF]

Pathogens, 2021
Puumala orthohantavirus (PUUV) causes a mild form of haemorrhagic fever with renal syndrome (HFRS) called nephropathia epidemica (NE), regularly diagnosed in Europe.
Vulin J, Murri S, Madrières S, Galan M, Tatard C, Piry S, Vaccari G, D'Agostino C, Charbonnel N, Castel G, Marianneau P.   +10 more
europepmc   +8 more sources

Dissection of the NKG2C NK cell response against Puumala Orthohantavirus. [PDF]

PLoS Negl Trop Dis, 2021
BackgroundInfections with the Puumala orthohantavirus (PUUV) in humans may cause hemorrhagic fever with renal syndrome (HFRS), known as nephropathia epidemica (NE), which is associated with acute renal failure in severe cases.
Vietzen H, Hartenberger S, Aberle SW, Puchhammer-Stöckl E.   +3 more
europepmc   +4 more sources

Isolation and characterization of new Puumala orthohantavirus strains from Germany. [PDF]

Virus Genes, 2020
Orthohantaviruses are re-emerging rodent-borne pathogens distributed all over the world. Here, we report the isolation of a Puumala orthohantavirus (PUUV) strain from bank voles caught in a highly endemic region around the city Osnabrück, north-west ...
Binder F, Reiche S, Roman-Sosa G, Saathoff M, Ryll R, Trimpert J, Kunec D, Höper D, Ulrich RG.   +8 more
europepmc   +10 more sources

Tropism of Puumala orthohantavirus and Endoparasite Coinfection in the Bank Vole Reservoir. [PDF]

Viruses, 2023
In Europe, most cases of human hantavirus disease are caused by Puumala orthohantavirus (PUUV) transmitted by bank voles (Clethrionomys glareolus, syn. Myodes glareolus), in which PUUV causes inconspicuous infection.
Schlohsarczyk EK, Drewes S, Koteja P, Röhrs S, Ulrich RG, Teifke JP, Herden C.   +6 more
europepmc   +9 more sources

Hantavirus Pulmonary Syndrome Caused by Puumala Orthohantavirus-A Case Report and Literature Review. [PDF]

Microorganisms, 2023
In this article, we report on a rare case of acute respiratory distress syndrome (ARDS) caused by the Puumala orthohantavirus (PUUV), which is typically associated with hemorrhagic fever with renal syndrome (HFRS).
Santini M, Ljubić J, Šoštar N, Vilibić-Čavlek T, Bogdanić M, Zakotnik S, Avšič-Županc T, Korva M, Kurolt IC, Radmanić L, Šimičić P, Krznarić J, Gjurašin B, Kutleša M, Višković K, Balent NC, Žunec R, Margeta Marić I, Ribarović A, Židovec-Lepej S.   +19 more
europepmc   +5 more sources

Neutralizing Antibody Titers in Hospitalized Patients with Acute Puumala Orthohantavirus Infection Do Not Associate with Disease Severity. [PDF]

Viruses, 2022
Nephropathia epidemica (NE), a mild form of haemorrhagic fever with renal syndrome (HFRS), is an acute febrile illness caused by Puumala orthohantavirus (PUUV). NE manifests typically with acute kidney injury (AKI), with a case fatality rate of about 0.1%
Iheozor-Ejiofor R, Vapalahti K, Sironen T, Levanov L, Hepojoki J, Lundkvist Å, Mäkelä S, Vaheri A, Mustonen J, Plyusnin A, Strandin TM, Vapalahti O.   +11 more
europepmc   +17 more sources

Orthohantavirus Isolated in Reservoir Host Cells Displays Minimal Genetic Changes and Retains Wild-Type Infection Properties [PDF]

Viruses, 2020
Orthohantaviruses are globally emerging zoonotic pathogens. While the reservoir host role of several rodent species is well-established, detailed research on the mechanisms of host-othohantavirus interactions has been constrained by the lack of an ...
Tomas Strandin, Teemu Smura, Paula Ahola, Kirsi Aaltonen, Tarja Sironen, Jussi Hepojoki, Isabella Eckerle, Rainer G. Ulrich, Olli Vapalahti, Anja Kipar, Kristian M. Forbes   +10 more
doaj   +6 more sources