Cluster of human Puumala orthohantavirus infections due to indoor exposure?—An interdisciplinary outbreak investigation [PDF]
Zoonoses and Public Health, 2022 Abstract Puumala orthohantavirus (PUUV) is the most important hantavirus species in Europe, causing the majority of human hantavirus disease cases. In central and western Europe, the occurrence of human infections is mainly driven by bank vole population dynamics influenced by beech mast.
Sabrina Weiss +2 more
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Impact of Landscape on Host–Parasite Genetic Diversity and Distribution Using the Puumala orthohantavirus–Bank Vole System [PDF]
Microorganisms, 2021 In nature, host specificity has a strong impact on the parasite’s distribution, prevalence, and genetic diversity. The host’s population dynamics is expected to shape the distribution of host-specific parasites.
Maria Razzauti +2 more
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Identification and genetic characterization of a distinct genotype of Puumala orthohantavirus in Hebei Province, China. [PDF]
PLoS Neglected Tropical DiseasesOrthohantavirus infections pose a significant threat to human health, while numerous orthohantaviruses have been identified, suspected viral infections remain undiagnosed in the world, which highlights the need for further identification and ...
Yanan Cai +11 more
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Characterization of the Puumala orthohantavirus Strains in the Northwestern Region of the Republic of Tatarstan in Relation to the Clinical Manifestations in Hemorrhagic Fever With Renal Syndrome Patients [PDF]
Frontiers in Pharmacology, 2019 Over 1,000 cases of hemorrhagic fever with renal syndrome (HFRS) were recorded in the Republic of Tatarstan (RT) in 2015. HFRS is a zoonotic disease caused by several different Old World hantaviruses.
Yuriy N. Davidyuk +9 more
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Circulating mucosal-like IgA responses increase with severity of Puumala orthohantavirus-caused hemorrhagic fever with renal syndrome [PDF]
Frontiers in ImmunologyOld World Orthohantaviruses cause hemorrhagic fever with renal syndrome (HFRS) characterized by increased vascular permeability and acute kidney injury (AKI).
Luz E. Cabrera +13 more
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Virus Research, 2023 Hemorrhagic fever with renal syndrome (HFRS) represents a serious zoonotic disease caused by orthohantaviruses in Eurasia. A specific antiviral therapy is not available.
Christian Nußhag, Ellen Krautkrämer
exaly +3 more sources
Clinical and genomic characterisation of a fatal Puumala orthohantavirus case with low levels of neutralising antibodies [PDF]
Infectious Diseases, 2022 Andreas Sjödin +2 more
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Puumala Orthohantavirus Reassortant Genome Variants Likely Emerging in the Watershed Forests [PDF]
International Journal of Molecular Sciences, 2023 Yuriy Davidyuk +2 more
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A Standardized workflow for Orthohantavirus production, detection, and antiviral screening [PDF]
Virology JournalBackground Orthohantaviruses are zoonotic RNA viruses that cause hemorrhagic fever with renal syndrome and hantavirus cardiopulmonary syndrome. Their slow replication, lack of cytopathic effects, and variable biosafety requirements have long hindered the
Hannah S. Schwarzer-Sperber +5 more
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Puumala orthohantavirus: prevalence, biology, disease, animal models and recent advances in therapeutics development and structural biology [PDF]
Frontiers in ImmunologyRobert Krause +2 more
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