Results 71 to 80 of about 1,657,450 (190)

Beech Fructification and Bank Vole Population Dynamics--Combined Analyses of Promoters of Human Puumala Virus Infections in Germany. [PDF]

PLoS One, 2015
The transmission of wildlife zoonoses to humans depends, amongst others, on complex interactions of host population ecology and pathogen dynamics within host populations. In Europe, the Puumala virus (PUUV) causes nephropathia epidemica in humans.
Reil D, Imholt C, Eccard JA, Jacob J.
europepmc   +2 more sources

Hormonal Defects Are Common during Puumala Hantavirus Infection and Associate with Disease Severity and Biomarkers of Altered Haemostasis

Viruses, 2021
Central and peripheral hormone deficiencies have been documented during and after acute hantavirus infection. Thrombocytopenia and coagulation abnormalities are common findings in haemorrhagic fever with renal syndrome (HFRS).
Marlene Tarvainen, Satu Mäkelä, Outi Laine, Ilkka Pörsti, Sari Risku, Onni Niemelä, Jukka Mustonen, Pia Jaatinen   +7 more
doaj   +1 more source

Hantavirus in rodents in the United States: Temporal and spatial trends and report of new hosts

Ecosphere, Volume 16, Issue 3, March 2025.
Abstract In North America, the rodent‐borne hantavirus pulmonary syndrome is predominantly caused by the Sin Nombre virus, typically associated with the deer mouse Peromyscus maniculatus. Utilizing data from the National Ecological Observatory Network (NEON) hantavirus program, we assessed factors that may influence the spatial and temporal ...
Francisca Astorga, Abdelghafar Alkishe, Paanwaris Paansri, Gabriel Mantilla, Luis E. Escobar   +4 more
wiley   +1 more source

Risk factors and potential preventive measures for nephropatia epidemica in Sweden 2011–2012: a case–control study [PDF]

Infection Ecology & Epidemiology, 2015
Introduction: Nephropatia epidemica (NE), a relatively mild form of hemorrhagic fever with renal syndrome caused by the Puumala virus (PUUV), is endemic in northern Sweden. We aim to study the risk factors associated with NE in this region.
Alin Gherasim, Marika Hjertqvist, Åke Lundkvist, Sharon Kühlmann-Berenzon, Jenny Verner Carlson, Stephan Stenmark, Mikael Widerström, Anders Österlund, Hans Boman, Clas Ahlm, Anders Wallensten   +10 more
doaj   +1 more source

Two Birds With One Stone: RNA Virus Strategies to Manipulate G3BP1 and Other Stress Granule Components

WIREs RNA, Volume 16, Issue 2, March/April 2025.
Stress granules emerging during viral infection can play both pro‐ and antiviral roles. RNA viruses use various strategies to antagonize their formation, including the degradation, inhibition, or sequestration of G3BP1, a key stress granule protein. However, biochemical and structural insights into these mechanisms have been reported for only a handful
Moh Egy Rahman Firdaus, Eliana Dukhno, Rupali Kapoor, Piotr Gerlach   +3 more
wiley   +1 more source

Phylogeography of Puumala orthohantavirus in Europe

Viruses, 2019
Puumala virus is an RNA virus hosted by the bank vole (Myodes glareolus) and is today present in most European countries. Whilst it is generally accepted that hantaviruses have been tightly co-evolving with their hosts, Puumala virus (PUUV) evolutionary ...
Guillaume Castel, François Chevenet, Maria Razzauti, Séverine Murri, Philippe Marianneau, Jean-François Cosson, Noël Tordo, Alexander Plyusnin   +7 more
doaj   +1 more source

Hantaan virus glycoprotein Gc induces NEDD4‐dependent PTEN ubiquitination and degradation to escape the restriction of autophagosomes and facilitate viral propagation

The FASEB Journal, Volume 39, Issue 1, 15 January 2025.
The proposed model of HTNV induced PTEN degradation and PTEN‐regulated autophagy in progeny virus production: In HTNV‐infected HK‐2 cells, the viral Gc glycoprotein specifically promotes NEDD4 mediated ubiquitination and degradation of PTEN. Disruption of PTEN expression prevents autophagosome formation and increases HTNV production, whereas ...
Shuang Lu, Shuliang Chen, Yuqing Zhang, Xiaoli Mou, Mingyang Li, Shaowei Zhu, Xingyuan Chen, Tomas M. Strandin, Yale Jiang, Zhoufu Xiang, Yuanyuan Liu, Hairong Xiong, Deyin Guo, Liangjun Chen, Yirong Li, Wei Hou, Fan Luo   +16 more
wiley   +1 more source

Reduction in mucosal‐associated invariant T cells (MAIT) in APECED patients is associated with elevated serum IFN‐γ concentration

European Journal of Immunology, Volume 54, Issue 12, December 2024.
We found a reduced frequency of circulating mucosal‐associated invariant T cells (MAITs) in patients with APECED with a clear negative correlation to inflammatory markers CRP, IL‐18, and IFN‐γ. These findings suggest that the decrease in MAITs is secondary to type 1 immune dysregulation present in the disease.
Iivo Hetemäki, Joona Sarkkinen, Huai Hui Wong, Nelli Heikkilä, Saila Laakso, Simo Miettinen, Mikko I. Mäyränpää, Outi Mäkitie, T Petteri Arstila, Eliisa Kekäläinen   +9 more
wiley   +1 more source

Natural Focal Viral Fevers in the South of the European Part of Russia. Hemorrhagic Fever with Renal syndrome

Проблемы особо опасных инфекций, 2020
Objective of the study was to determine the modem epizootic and epidemic peculiarities of hemorrhagic fever with renal syndrome in the south of the European part of Russia. Materials and methods.
O. V. Maletskaya, T. V. Taran, D. A. Prislegina, A. E. Platonov, V. M. Dubyansky, A. S. Volynkina, N. F. Vasilenko, Yu. N. Tokhov, N. V. Tsapko   +8 more
doaj   +1 more source

Antibody feedback regulation

Immunological Reviews, Volume 328, Issue 1, Page 126-142, November 2024.
Summary Antibodies are able to up‐ or downregulate antibody responses to the antigen they bind. Two major mechanisms can be distinguished. Suppression is most likely caused by epitope masking and can be induced by all isotypes tested (IgG1, IgG2a, IgG2b, IgG3, IgM, and IgE).
Birgitta Heyman
wiley   +1 more source