Results 21 to 30 of about 70,518 (282)

Computer-aided design of PVR mutants with enhanced binding affinity to TIGIT

Cell Communication and Signaling, 2021
Background TIGIT, as a novel immune checkpoint molecule involved in T cell and NK cell anergy, could induce the immune tolerance and escape through binding with its ligand PVR.
Xiaowen Zhou, Jiangfeng Du, Xiuman Zhou, Xiaoshuang Niu, Wanqiong Li, Chunxia Chen, Sifan Lv, Aijun Wu, Shanshan Gou, Yixuan Sun, Wenjie Zhai, Lu Qiu, Yuanming Qi, Wenshan Zhao, Yanfeng Gao   +14 more
doaj   +1 more source

PVR/TIGIT and PD-L1/PD-1 expression predicts survival and enlightens combined immunotherapy in lung squamous cell carcinoma

Translational Oncology, 2022
PVR/TIGIT and PD-L1/PD-1 axes play essential roles in tumor immune evasion and could be potential targets for combined immunotherapy. We aimed to evaluate the expression status of the above-mentioned immune markers in lung squamous cell carcinoma (LUSC),
Zhenlin Yang, Yue Peng, Jiachen Xu, Ping Chen, Zhenshan Zhao, Qingyuan Cai, Lin Li, He Tian, Guangyu Bai, Lei Liu, Shugeng Gao, Jie He   +11 more
doaj   +1 more source

Tricuspid Valve Intervention at the Time of Pulmonary Valve Replacement in Adults With Congenital Heart Disease: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Tricuspid regurgitation (TR) is a common finding in adults with congenital heart disease referred for pulmonary valve replacement (PVR). However, indications for combined valve surgery remain controversial.
Jef Van den Eynde, Connor P. Callahan, Mauro Lo Rito, Nabil Hussein, Horacio Carvajal, Alvise Guariento, Arjang Ruhparwar, Alexander Weymann, Werner Budts, Marc Gewillig, Michel Pompeu Sá, Shelby Kutty   +11 more
doaj   +1 more source

Hepatocellular Carcinoma Cells Upregulate PVRL1, Stabilizing PVR and Inhibiting the Cytotoxic T-cell Response via TIGIT to Mediate Tumor Resistance to PD1 Inhibitors in Mice.

Gastroenterology, 2020
BACKGROUND & AIMS Immune checkpoint inhibitors are effective in treatment of some hepatocellular carcinomas (HCCs), but these tumors do not always respond to inhibitors of programmed cell death 1 (PDCD1, also called PD1).
David Kung‐Chun Chiu, V. W. Yuen, J. W. Cheu, Larry Lai Wei, V. Ting, M. Fehlings, Hermi Sumatoh, A. Nardin, E. Newell, I. Ng, T. Yau, Chun‐Ming Wong, C. C. Wong   +12 more
semanticscholar   +1 more source

Overexpression of PVR and PD-L1 and its association with prognosis in surgically resected squamous cell lung carcinoma

Scientific Reports, 2021
Targeting T-Cell Immunoreceptor with Ig and ITIM domain-poliovirus receptor (PVR) pathway is a potential therapeutic strategy in lung cancer. We analyzed the expression of PVR and programmed death ligand-1 (PD-L1) in surgically resected squamous cell ...
Jii Bum Lee, M. Hong, S. Park, Sehyun Chae, D. Hwang, S. Ha, H. Shim, H. R. Kim   +7 more
semanticscholar   +1 more source

Managing PVR in the Era of Small Gauge Surgery

Journal of Ophthalmology, 2021
Proliferative vitreoretinopathy (PVR) is the leading cause of failed rhegmatogenous retinal detachment (RRD) surgery. Based upon the presence of clinical features and due to associated underlying risk factors, it is classified into various grades based ...
M. Nagpal, Rakesh Juneja, S. Talati
semanticscholar   +1 more source

Vitrectomy in combination with endo-thermotherapy of angiomas and feeding vessels in the surgical treatment of retinal detachment with proliferative vitreoretinopathy in von Hippel-Lindau desease

Офтальмохирургия, 2018
Actuality. Von Hippel-Lindau disease is a rare autosomal dominant multi-systemic disease, characterized by the presence of vascular formations (angiomas) of different localization.
E. V. Boyko, Y. V. Bayborodov, K. S. Zhogolev, D. S. Maltsev   +3 more
doaj   +1 more source

Targeting the “PVR–TIGIT axis” with immune checkpoint therapies

F1000Research, 2020
Checkpoint inhibitors have become an efficient way to treat cancers. Indeed, anti-CTLA-4, anti-PD1, and anti-PDL-1 antibodies are now used as therapies for cancers.
L. Gorvel, D. Olive
semanticscholar   +1 more source

A spectral approach to a constrained optimization problem for the Helmholtz equation in unbounded domains [PDF]

, 2014
We study some convergence issues for a recent approach to the problem of transparent boundary conditions for the Helmholtz equation in unbounded domains.
Ciraolo, Giulio, Gargano, Francesco, Sciacca, Vincenzo   +2 more
core   +2 more sources

Inaccuracy of a non-invasive estimation of pulmonary vascular resistance assessed by cardiovascular magnetic resonance in heart failure patients

Scientific Reports, 2021
Pulmonary vascular resistance (PVR) is a marker of pulmonary vascular remodeling. A non-invasive model assessed by cardiovascular magnetic resonance (CMR) has been proposed to estimate PVR.
Eva Rumiz, Andrés Cubillos, Juan Vicente Vilar, Pilar García, Alberto Berenguer, Lorenzo Fácila, Ernesto Valero, Verónica Vidal, Salvador Morell, Julio Nuñez   +9 more
doaj   +1 more source