Results 41 to 50 of about 35,871 (258)

The IgV domain of the poliovirus receptor alone is immunosuppressive and binds to its receptors with comparable affinity

Scientific Reports, 2023
PVR (poliovirus receptor) functions as a ligand that signals through TIGIT and CD96 to induce suppression of T-cell and NK-cell responses. Alternatively, PVR binds to CD226, resulting in a co-stimulatory signal.
Shrayasee Saha, Amanda Sparkes, Esther I. Matus, Peter Lee, Jean Gariépy   +4 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Assessing the acceptability of the progesterone vaginal ring (PVR) in Kenya, Nigeria, and Senegal

, 2021
This research assessed the acceptability of PVR among postpartum women in sub-Saharan Africa. It was conducted as part of pre-introduction efforts aimed at expanding the method choice and reducing unmet need for contraception during the postpartum period.
Townsend, John, Liambila, Wilson, Ishaku, Salisu, Unumeri, Godwin, Mane, Babacar, Diop, Nafissatou, Obare, Francis, Birungi, Harriet, RamaRao, Saumya, Clark, Heather, Rajamani, Deepa, Nafi Diop, Deepa Rajamani, Salisu Ishaku, Harriet Birungi, Saumya RamaRao, Heather Clark, Francis Obare, Wilson Liambila, Babacar Mane, Godwin Unumeri, John Townsend   +21 more
core   +2 more sources

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Minimally invasive PVR surgery-MIPS

Indian Journal of Ophthalmology. Case Reports
Background: Proliferative vitreoretinopathy (PVR) is one of the main reasons for recurrent retinal detachments, usually requiring multiple re-surgeries. This technique of minimally invasive PVR surgery (MIPS) provides a simpler and cost-effective way of ...
Giriraj Vibhute, Shrinivas Joshi, Apoorva Ayachit, Guruprasad Ayachit   +3 more
doaj   +1 more source

The Drosophila Pvr Pathway Regulates Innate Immunity and Intestinal Homeostasis [PDF]

, 2013
The innate immune system is an evolutionarily conserved first line of defense against invasive microbes. Studies in the fruit fly, Drosophila melanogaster, revolutionized the field of immunology and cemented Drosophila as a premier model of innate immune
Bond, David JE
core   +1 more source

Ion‐Reconfigurable “N”‐Shaped Antiambipolar Behavior in Organic Electrochemical Transistors

Advanced Materials, EarlyView.
A unique N‐shaped negative differential transconductance (NDT) characteristics is demonstrated in single‐polymer organic electrochemical transistors through a sequential doping–redox–doping process driven by iodide ions. This redox‐driven mechanism enables low‐voltage, ion‐controlled reconfigurability and tunable current modulation, allowing seamless ...
Debdatta Panigrahi, Daniele Zucchelli, Zeinab Hamid, Christina Kousseff, Arup Sarkar, Aristea Pavlou, Zhitian Ling, Somayeh Kashani, Iain McCulloch, Paul W. M. Blom, Fabrizio Torricelli, Paschalis Gkoupidenis   +11 more
wiley   +1 more source

Evaluation of Left Ventricular Systolic Function after Pulmonary Valve Replacement Using Cardiovascular Magnetic Resonance Imaging

Cardiovascular Innovations and Applications, 2018
Following reparative surgery for tetralogy of Fallot or critical pulmonary stenosis (PS), patients frequently present with severe right ventricular (RV) volume overload due to pulmonary regurgitation, resulting in decreased RV function.
W. Aaron Kay
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Pulmonary valve replacement-related change in biventricular global function index in repaired tetralogy of Fallot

Journal of Cardiovascular Magnetic Resonance
Background: Reduced biventricular global function index (BVGFI) is associated with adverse outcomes in repaired tetralogy of Fallot (rTOF). The change in BVGFI associated with pulmonary valve replacement (PVR) is unknown.
Shanique Sterling-Lovy, Francesca Sperotto, Lynn A. Sleeper, Minmin Lu, Vedang Diwanji, Edward O’Leary, Anne Marie Valente, Tal Geva   +7 more
doaj   +1 more source