Results 51 to 60 of about 35,871 (258)

Does post-void residual urine volume affect potential recurrence risk for non-muscle invasive bladder cancer?

Future Science OA, 2022
Aim: Bladder cancer is the second most common urological malignancy after prostate cancer. Increase in the post-void residual (PVR) volume may result in an increase in the risk of cancer recurrence.
Mohammad Talal Al-Zubi, Saddam Al Demour, Samer Fathi Al-Rawashdah, Antonio Carbone, Antonio Luigi Pastore, Mohannad Abuhamad, Saleh Abuorouq, Rami Al-Azab, Morad Bani-Hani, Mohammad Al-Qudah, Basel Elayan   +10 more
doaj   +1 more source

Retinal detachment without PVR

, 2013
In patients suffering from a retinal detachment, the identification of all the breaks is crucial. In cases without any PVR, scleral buckling remains the first line treatment especially for ora dialysis or long standing Retinal Detachment (RD) linked to ...
Creuzot Garcher, Catherine
core   +1 more source

Negative regulation of p53 by the poliovirus receptor PVR is a target of a human cytomegalovirus immune evasion molecule

, 2022
Initially characterised for its role in maintaining genome integrity, p53 has emerged as a critical hub for coordinating cellular responses to diverse types of stress. Here we identify cell surface receptor loss as a signal for p53 induction.
Jones, Pamela F., Cook, Graham P., Odell, Adam, Mannion, Aarren J., Adam F. Odell, Pamela F. Jones, Graham P. Cook, Aarren J. Mannion   +7 more
core   +1 more source

Initial treatment strategies and outcomes across haemodynamic thresholds and risk stratification in incident systemic sclerosis–associated pulmonary arterial hypertension: a EUSTAR analysis

Arthritis &Rheumatology, Accepted Article.
Objective Real‐world initial treatment strategies in SSc‐PAH remain incompletely described. We aimed to characterise these strategies across haemodynamic thresholds and risk strata and evaluate outcome associations. Methods We analysed treatment‐naïve SSc‐PAH patients in EUSTAR (2000–2021) fulfilling the 2022 haemodynamic definition.
Hilde Jenssen Bjørkekjær, Cosimo Bruni, Kaspar Broch, Cathrine Brunborg, Patricia E Carreira, Paolo Airò, Carmen Pilar Simeón‐Aznar, Marie‐Elise Truchetet, Alessandro Giollo, Alexandra Balbir‐Gurman, Mickael Martin, Christopher P Denton, Armando Gabrielli, Francesco Del Galdo, Madelon C. Vonk, Håvard Fretheim, Helle Bitter, Øyvind Midtvedt, Arne K. Andreassen, Sverre Høie, Yoshiya Tanaka, Gabriela Riemekasten, Ulf Müller‐Ladner, Marco Matucci‐Cerinic, Ivan Castellví, Elise Siegert, Eric Hachulla, Øyvind Molberg, Oliver Distler, Anna‐Maria Hoffmann‐Vold, on behalf of the EUSTAR collaborators   +30 more
wiley   +1 more source

DAPL1 prevents epithelial–mesenchymal transition in the retinal pigment epithelium and experimental proliferative vitreoretinopathy

Cell Death and Disease, 2023
Epithelial–mesenchymal transition (EMT) of the retinal pigment epithelium (RPE) is a hallmark of the pathogenesis of proliferative vitreoretinopathy (PVR) that can lead to severe vision loss. Nevertheless, the precise regulatory mechanisms underlying the
Xiaoyin Ma, Shuxian Han, Youjia Liu, Yu Chen, Pingping Li, Xiaoyan Liu, Lifu Chang, Ying-ao Chen, Feng Chen, Qiang Hou, Ling Hou   +10 more
doaj   +1 more source

Post-PVR outcome predictions using 1G models.

, 2019
Post-PVR outcome predictions using 1G models.
Pedro J. del Nido (7245137), Han Yu (110573), Chun Yang (251691), Xueying Huang (1574125), Rahul H. Rathod (3120015), Tal Geva (3120012), Kristen L. Billiar (7245134), Zheyang Wu (261398), Dalin Tang (835554)   +8 more
core   +1 more source

Adaptive imatinib regimens can mitigate cumulative toxicity while sustaining hemodynamic benefit: A model‐based simulation of the positioning imatinib for pulmonary arterial hypertension trial

British Journal of Clinical Pharmacology, EarlyView.
ABSTRACT Aims Imatinib improves hemodynamics in pulmonary arterial hypertension (PAH), but dose‐dependent toxicity has limited its clinical development. We aimed to quantify the dose–efficacy–toxicity relationship and evaluate alternative dosing strategies using data from the PIPAH trial.
Medhat M. Said, Robert B. de Mooij, Dian Jiao, Reitze J. Ovelgonne, Rami Biram, Juan Delgado‐SanMartin, Alexander M. K. Rothman, Sofia S. Villar, Andreas A. Roussakis, Jurjan Aman, Ron A. A. Mathôt, Eleonora L. Swart, Martin R. Wilkins, Imke H. Bartelink   +13 more
wiley   +1 more source

CYP3A5 genetic variability influences sildenafil and metabolite in pulmonary hypertension

British Journal of Clinical Pharmacology, EarlyView.
Aim Interindividual variability in sildenafil response among pulmonary hypertension patients (PH) may be influenced by CYP3A5 polymorphisms. CYP3A5*3 allele reduces CYP3A5 activity and affects sildenafil metabolism. This study investigated the associations between CYP3A5 genotype and plasma concentrations of sildenafil and N‐desmethyl sildenafil, as ...
Pranisa Wongwien, Burabha Pussadhamma, Sirimas Kanjanawart, Thikhumporn Areesinpitak, Nontaya Nakkam, Chingching Foocharoen, Wichittra Tassaneeyakul, Suda Vannaprasaht   +7 more
wiley   +1 more source

Model of Pvr and InR impact on cell survival control.

, 2015
Signaling scheme of Pvr, and its Enhancer InR and Suppressors EcR/Usp, which were identified by RNAi screening. Pvr and InR trigger the phosphorylation of many common targets of redundant survival pathways (see also Fig. 1F).
Kalpana Makhijani (699756), Katja Brückner (247370), Richelle Sopko (259972), You Bin Lin (699755), Norbert Perrimon (14159), Brandy Alexander (699757)   +5 more
core   +1 more source

Biventricular Pressure‐Volume Loop Analysis in an LVAD Patient Optimized With Impella RP Flex

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Right ventricular (RV) failure after left ventricular assist device (LVAD) implantation is a serious complication which may necessitate temporary mechanical support in refractory cases. Here we describe a 63‐year‐old man with end‐stage ischemic cardiomyopathy and severe combined pre‐ and post‐capillary pulmonary hypertension who developed ...
Sara S. Inglis, Serena Rahme, Andrew N. Rosenbaum, Atta Behfar   +3 more
wiley   +1 more source