Results 71 to 80 of about 70,518 (282)
Oncogene, 2018 Immune checkpoints are promising targets in cancer therapy. Recently, poliovirus receptor (PVR) and poliovirus receptor-related 2 (PVRL2) have been identified as novel immune checkpoints.
H. Stamm +18 more
semanticscholar +1 more source
TriCON: A Carbon‐Based Triple‐Modal Nanoplatform for Pancreatic Cancer Therapy
Advanced Science, EarlyView.We developed TriCON, a triple‐modality nanotherapeutic platform, to treat pancreatic ductal adenocarcinoma (PDAC) by synergizing gene editing, chemotherapy, and immunotherapy. TriCON utilizes CRISPR/Cas9 to target the poliovirus receptor (PVR), combined with nano‐encapsulated doxorubicin and checkpoint blockade. This approach achieved significant tumor
Xinyu Peng +9 more
wiley +1 more source
Sensitive detection systems for infectious agents in xenotransplantation*
Xenotransplantation, EarlyView., 2020 Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley +1 more source
Cardiovascular Innovations and Applications, 2018 Following reparative surgery for tetralogy of Fallot or critical pulmonary stenosis (PS), patients frequently present with severe right ventricular (RV) volume overload due to pulmonary regurgitation, resulting in decreased RV function.
W. Aaron Kay
doaj +1 more source
Can feeling of incomplete bladder emptying reflect significant postvoid residual urine? Is it reliable as a symptom solely? [PDF]
Investigative and Clinical Urology, 2018 Purpose: The main objective of this study was to reveal the relationship between lower urinary tract symptoms (LUTS) and post-void residual (PVR) urine volume.
Yusuf Özlülerden +6 more
doaj +1 more source
Biomarkers for PVR in rhegmatogenous retinal detachment
PLoS ONE, 2019 Purpose Various profibrotic and proinflammatory cytokines have been found upregulated in uncomplicated primary retinal detachment (pRD), but without providing a uniform picture.
S. Zandi +7 more
semanticscholar +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Der Portalversuchsrahmen (PVR)
, 1999 Zukünftig wird bei der ökonomischen Optimierung im Gartenbau die Schonung von Ressourcen stärker zu beachten sein. Hierzu ist für die integrierte Produktion zunächst ein geschlossener Informationskreislauf in Kombination mit einer präzisen Kulturtechnik erforderlich.
Römer, Hans Peter +2 more
openaire +1 more source
Advanced Science, EarlyView.Microwave ablation (MWA) represents a highly effective and clinically significant therapeutic modality for the treatment of liver metastases. This study develops engineered cell membrane vesicles to specifically target the transition zone of MWA for liver metastases. This strategy can inhibit VEGF‐mediated immunosuppression, block CD155/TIGIT signaling
Shaoyue Li +16 more
wiley +1 more source