Results 141 to 150 of about 13,268 (174)
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Nature Reviews Drug Discovery, 2002
Mechanisms that protect the body from a diverse array of harmful chemicals are also involved in drug metabolism, and can cause adverse drug-drug interactions. Two closely related orphan nuclear hormone receptors--the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR)--have recently emerged as transcriptional regulators of ...
Timothy M, Willson, Steven A, Kliewer
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Mechanisms that protect the body from a diverse array of harmful chemicals are also involved in drug metabolism, and can cause adverse drug-drug interactions. Two closely related orphan nuclear hormone receptors--the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR)--have recently emerged as transcriptional regulators of ...
Timothy M, Willson, Steven A, Kliewer
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Drug Metabolism and Disposition, 2008
The pregnane X receptor (PXR) is known as the xenosensing receptor responsible for coordinated regulation of metabolic genes in response to diverse xenobiotic challenges. In particular, the ability of the PXR to regulate CYP3A4, the enzyme capable of metabolizing more than 60% of all pharmaceuticals, defines its metabolic importance. Currently the list
Leslie M, Tompkins +2 more
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The pregnane X receptor (PXR) is known as the xenosensing receptor responsible for coordinated regulation of metabolic genes in response to diverse xenobiotic challenges. In particular, the ability of the PXR to regulate CYP3A4, the enzyme capable of metabolizing more than 60% of all pharmaceuticals, defines its metabolic importance. Currently the list
Leslie M, Tompkins +2 more
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Toxicology and Applied Pharmacology, 2004
To gain insight on the expression of pregnane X receptor (PXR), we analyzed PXR.1 and PXR alternatively spliced transcripts in a panel of 36 human tissues. PXR.1 was expressed in many more tissues than previously determined, including human bone marrow and select regions of the human brain.
Vishal Lamba +2 more
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To gain insight on the expression of pregnane X receptor (PXR), we analyzed PXR.1 and PXR alternatively spliced transcripts in a panel of 36 human tissues. PXR.1 was expressed in many more tissues than previously determined, including human bone marrow and select regions of the human brain.
Vishal Lamba +2 more
exaly +3 more sources
Functional and structural comparison of PXR and CAR
Biochimica Et Biophysica Acta - General Subjects, 2003The nuclear receptors pregnane X receptor (PXR, NR1I2) and constitutive active receptor (CAR, NR1I3) have both been proposed to function as xenosensors, but the details of their respective physiological roles are still being elucidated. We have contrasted these two receptors in a variety of experiments including gene expression assays, cell-based ...
Linda B Moore, Jodi M Maglich
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CAR and PXR: Xenosensors of endocrine disrupters?
Chemico-Biological Interactions, 2005The pregnane X-receptor (PXR) and the constitutive androstane receptor (CAR) are orphan nuclear receptors activated by a variety of ligands. Currently it remains uncertain whether these receptors have a high-affinity ligand or instead function as more generalized steroid/xenobiotic sensors. Both receptors are important regulators of several steroid and
Xiomara C, Kretschmer +1 more
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Journal of steroid biochemistry and molecular biology, 2012
Cholestatic liver disorders encompass hepatobiliary diseases of diverse etiologies characterized by the accumulation of bile acids, bilirubin and cholesterol as the result of impaired secretion of bile. Members of the nuclear receptor (NR) family of ligand-modulated transcription factors are implicated in the adaptive response to cholestasis.
Jonker, Johan W. +2 more
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Cholestatic liver disorders encompass hepatobiliary diseases of diverse etiologies characterized by the accumulation of bile acids, bilirubin and cholesterol as the result of impaired secretion of bile. Members of the nuclear receptor (NR) family of ligand-modulated transcription factors are implicated in the adaptive response to cholestasis.
Jonker, Johan W. +2 more
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Genetic Variability of PXR in Saudi Arabians
Biochemical Genetics, 2013Polymorphisms in the PXR gene play important roles in influencing the efficacy and toxicity of a large number of endogenous and exogenous substrates. Because of ethnic specificity, several studies have been directed toward the determination of PXR polymorphisms in various populations.
Mohammed S, Al-Dosari +8 more
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Investigations and Properties of PXR
2002A brief historical sketch on investigations of parametric X-ray radiation (PXR) is presented. The nature of PXR is discussed. The main spectral, angular and polarization properties of the PXR are described. Some possible applications of PXR as a source of linearly polarized, quasi monochromatic, smoothly tunable X-ray beams for energies from a few keV ...
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Xenobiotic Receptors CAR and PXR
2010The absorption, distribution, metabolism, and excretion (ADME) of chemicals are coordinately fulfilled by drug transporters as well as phase-I and phase-II drug-metabolizing enzymes. The two so-called “xenobiotic receptors”, namely constitutive active/androstane receptor (CAR, NR1I3) and pregnane X receptor (PXR, NR1I2), are predominantly expressed in ...
Curtis Klaassen, Hong Lu
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The xenobiotic receptors PXR and CAR in liver physiology, an update
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2021Xinran Cai, Wen Xie
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