Results 131 to 140 of about 13,268 (174)

Geranylgeraniol promotes osteoblast differentiation and inhibits osteoclastogenesis through MAPK and nuclear receptor signaling. [PDF]

J Biol Chem
Tomomura M, Tsukahara T, Suzuki R, Sakagami H, Bandow K, Tomomura A.   +5 more
europepmc   +1 more source

Cardioprotective Chinese herbs and antiretroviral drug metabolism: a systematic review of in vitro evidence. [PDF]

Front Pharmacol
Cheng WJ, Jaworowski A, Trevillyan JM, Hearps AC, Xue CC, Zhang AL.   +5 more
europepmc   +1 more source

Molecular Signature of Cisplatin Resistance in Ovarian Cancer Identifies Therapeutic Opportunities for Re-sensitization. [PDF]

J Cancer
Mansour M, van Ginkel S, Alata M, Bani I, Elhussin I.   +4 more
europepmc   +1 more source

Impact of Efavirenz on Heme Protein Induction and Biomarkers: Insights From In Vitro Experiments and a Clinical Study. [PDF]

Clin Transl Sci
Potzel L, Kinzi J, Seibert I, Grube M, Siegmund W, Meyer Zu Schwabedissen HE.   +5 more
europepmc   +1 more source

Mechanisms and Therapeutic Advances of PXR in Metabolic Diseases and Cancer. [PDF]

Int J Mol Sci
Bi Y, Liu S, Wang L, Peng D, Chen W, Zhang Y, Wang Y.   +6 more
europepmc   +1 more source

Integrated single-cell transcriptomics and proteomics elucidate the molecular mechanisms and detoxification strategy of rifampicin-induced hepatotoxicity. [PDF]

Int J Biol Sci
Chen J, Zhang Q, Huang J, He H, Bai Y, An Y, Hao M, Zhao W, Li W, Feng S, Yang S, Liao J, Wong YK, Dai L, Du Q, Luo P, Wang J.   +16 more
europepmc   +1 more source

Gut microbial-derived indole-3-propionate improves cognitive function in Alzheimer's disease. [PDF]

Sci Adv
Li L, Jia M, Yang C, Zhao Y, Hu J, Zhao Y, Hu X, Ning F, Ding C, Li Q, Gong J, Jia X, Xu K, Wang Y, Zhou S, Deng L, Shi L, Chen X, Chen X, Liu X, Liu Z.   +20 more
europepmc   +1 more source

Nuclear Receptor PXR in Drug-Induced Hypercholesterolemia [PDF]

Cells, 2022
Atherosclerosis is a major global health concern. The central modifiable risk factors and causative agents of the disease are high total and low-density lipoprotein (LDL) cholesterol. To reduce morbidity and mortality, a thorough understanding of the factors that influence an individual’s cholesterol status during the decades when the arteria-narrowing
Mikko Karpale, Janne Hukkanen, Jukka Hakkola   +2 more
exaly   +5 more sources

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Beyond CAR and PXR

Current Drug Metabolism, 2005
It is becoming increasingly evident that constitutive, induced, and regulated expression of genes important to the drug disposition process such as drug transporters, phase I and II metabolic enzymes are largely under the transcriptional control of certain nuclear receptor (NR) family members.
Santosh G, Dixit, Rommel G, Tirona, Richard B, Kim   +2 more
openaire   +2 more sources

PXR and CAR in energy metabolism

Trends in Endocrinology & Metabolism, 2009
The nuclear receptors pregnane X receptor (PXR, or NR1I2) and constitutive androstane receptor (CAR, or NR1I3) were originally identified as xenosensors that regulate the expression of Phase I and Phase II drug-metabolizing enzymes and transporters. Recent results suggest that PXR and CAR also have important endobiotic roles in energy metabolism by ...
Taira, Wada, Jie, Gao, Wen, Xie
openaire   +2 more sources