Results 111 to 120 of about 13,268 (174)

Coenzyme Q10 protects against atorvastatin-induced hepatotoxicity via attenuation of oxidative stress and functional modulation of CYP3A1. [PDF]

BMC Pharmacol Toxicol
Abdel-Rasol MA, Anwar MS, Taha HA, El-Sayed WM, AbdelRaouf K.   +4 more
europepmc   +1 more source

Sustained Drug-Drug Interaction Between Cyclosporine and Apalutamide in a Patient With Metastatic Hormone-Sensitive Prostate Cancer: A Case Report and Evaluation of CYP3A4 Induction via Pregnane X Receptor Activation by Apalutamide. [PDF]

Case Rep Oncol Med
Mimura Y, Sanda T, Unno R, Furukawa Y, Shizu R, Motokatsu K, Tashiro Y, Tasaki Y, Sugiyama Y, Yasujima T, Naiki T, Horita Y, Hotta Y, Yuasa H, Yoshinari K, Yasui T, Iida S, Furukawa-Hibi Y.   +17 more
europepmc   +1 more source

Metabolic Disruption and Steatosis Induced by Drinking Water Disinfection Byproducts in HepG2 and HUH7 Cells. [PDF]

Toxics
Mollari M, Galli FS, Cerasa MT, Cuva C, Zilli R, Ubaldi A, Scicluna MT, Barbaro K, Mantovani A, Marcoccia D.   +9 more
europepmc   +1 more source

Mutation of PXR phosphorylation motif at Ser347 disrupts lipid and bile acid homeostasis in diet-induced metabolic dysfunction-associated steatohepatitis in mice. [PDF]

Drug Metab Dispos
Basaly V, Henry ZR, Taylor RE, Kong B, Yang I, Brinker A, Yang Z, Zhou P, Joseph LB, Aleksunes L, Buckley B, Negishi M, Guo GL.   +12 more
europepmc   +1 more source

Schisandrin B Targets PXR to Enhance Bile Acid Metabolism and Alleviate ANIT-Induced Cholestatic Liver Injury via Dual Pathways. [PDF]

Int J Biol Sci
Zhang Y, Lan H, Yu X, Zhuo L, Zhao B, Liu F, An L, Zhang F, Liu Z, Wang C.   +9 more
europepmc   +1 more source

Gut microbiota-derived tryptophan metabolites: molecular mechanisms, nutritional strategies and implications for swine health. [PDF]

Front Vet Sci
Wen Y.
europepmc   +1 more source

Discovery and Optimization of Potent and Subtype-Selective Urea-Derived Na_V1.8 Inhibitors. [PDF]

ACS Med Chem Lett
Dialer C, Krüger S, Wagener M, Mülbaier M, Peil S, Marigo M, Hagendorf S, Cao L, Molina CR, Morgan P, Young C, Ribeiro LR, Slynko I, Ritter S, Guberman M, Hass M, Klosky S, la Tendresse U, Gussmann C, Kühnert S, Peters S, Reichardt-Ockenfeld S, Depmeier H, Jakob F.   +23 more
europepmc   +1 more source

Mapping the avoid-ome: a systematic open-science approach to predictive ADMET. [PDF]

Nat Commun
Fraser JS, Edgar S, Handly LN, Kosuri S, Chodera JD, Murcko M, Walters WP.   +6 more
europepmc   +1 more source

The impact of cannabidiol (CBD) in hyperglycemic zebrafish (Danio rerio). [PDF]

PLoS One
McCarthy E, Gertner L, Ciocirlan J, Connaughton VP.   +3 more
europepmc   +1 more source

Bisphenol F and Steatotic Liver Disease: Resolving the PXR Paradox Through Stress Pathway Mechanisms. [PDF]

Biomedicines
AbdalHussin EA, Abd Hamid Z, Md Idris MH, Omar MH, Taib IS.   +4 more
europepmc   +1 more source