Results 91 to 100 of about 13,268 (174)

Pregnane X receptor activation constrains mucosal NF-κB activity in active inflammatory bowel disease.

PLoS ONE, 2019
BACKGROUND:The Pregnane X Receptor (PXR) is a principal signal transducer in mucosal responses to xenobiotic stress. It is well-recognized that inflammatory bowel disease is accompanied by xenobiotic stress, but the importance of the PXR in limiting ...
J Jasper Deuring, Meng Li, Wanlu Cao, Sunrui Chen, Wenshi Wang, Colin de Haar, C Janneke van der Woude, Maikel Peppelenbosch   +7 more
doaj   +1 more source

Targeting the pregnane X receptor using microbial metabolite mimicry

EMBO Molecular Medicine, 2020
The human PXR (pregnane X receptor), a master regulator of drug metabolism, has essential roles in intestinal homeostasis and abrogating inflammation. Existing PXR ligands have substantial off‐target toxicity.
Zdeněk Dvořák, Felix Kopp, Cait M Costello, Jazmin S Kemp, Hao Li, Aneta Vrzalová, Martina Štěpánková, Iveta Bartoňková, Eva Jiskrová, Karolína Poulíková, Barbora Vyhlídalová, Lars U Nordstroem, Chamini V Karunaratne, Harmit S Ranhotra, Kyu Shik Mun, Anjaparavanda P Naren, Iain A Murray, Gary H Perdew, Julius Brtko, Lucia Toporova, Arne Schön, Bret D Wallace, William G Walton, Matthew R Redinbo, Katherine Sun, Amanda Beck, Sandhya Kortagere, Michelle C Neary, Aneesh Chandran, Saraswathi Vishveshwara, Maria M Cavalluzzi, Giovanni Lentini, Julia Yue Cui, Haiwei Gu, John C March, Shirshendu Chatterjee, Adam Matson, Dennis Wright, Kyle L Flannigan, Simon A Hirota, Ryan Balfour Sartor, Sridhar Mani   +41 more
doaj   +1 more source

Pregnane × Receptor (PXR) expression in colorectal cancer cells restricts irinotecan chemosensitivity through enhanced SN-38 glucuronidation

Molecular Cancer, 2010
Background Clinical efficacy of chemotherapy in colorectal cancer is subjected to broad inter-individual variations leading to the inability to predict outcome and toxicity.
Lumbroso Serge, Hollande Frédéric, Joubert Dominique, Bonnans Caroline, Poujol Sylvain, Lallemant Benjamin, Kantar Jovana, Breuker Cyril, Leguelinel Géraldine, Pascussi Jean-Marc, Raynal Caroline, Brouillet Jean-Paul, Evrard Alexandre   +12 more
doaj   +1 more source

B3galt5 functions as a PXR target gene and regulates obesity and insulin resistance by maintaining intestinal integrity

Nature Communications
Pregnane X receptor (PXR) has been reported to regulate glycolipid metabolism. The dysfunction of intestinal barrier contributes to metabolic disorders. However, the role of intestinal PXR in metabolic diseases remains largely unknown. Here, we show that
Jinhang Zhang, Ya Huang, Hong Li, Pengfei Xu, Qinhui Liu, Yang Sun, Zijing Zhang, Tong Wu, Qin Tang, Qingyi Jia, Yan Xia, Ying Xu, Xiandan Jing, Jiahui Li, Li Mo, Wen Xie, Aijuan Qu, Jinhan He, Yanping Li   +18 more
doaj   +1 more source

Identification of human pregnane X receptor antagonists utilizing a high-throughput screening platform

Frontiers in Pharmacology
Pregnane X receptor (PXR) is a xenobiotic-sensing nuclear receptor with a well-established role in regulating drug metabolism and clearance. Recent studies have shown that PXR is involved in cell proliferation, apoptosis, immune response, and energy ...
Caitlin Lynch, Ryan Margolis, Jacob Niebler, Jameson Travers, Srilatha Sakamuru, Tongan Zhao, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xia   +8 more
doaj   +1 more source

Pregnane X receptor reduces particulate matter-induced type 17 inflammation in atopic dermatitis

Frontiers in Immunology
BackgroundEpidemiological evidence suggests that particulate matter (PM) exposure can trigger or worsen atopic dermatitis (AD); however, the underlying mechanisms remain unclear. Recently, pregnane X receptor (PXR), a xenobiotic receptor, was reported to
Ji Su Lee, Ji Su Lee, Youngae Lee, Youngae Lee, Youngae Lee, Sunhyae Jang, Sunhyae Jang, Sunhyae Jang, Jang-Hee Oh, Jang-Hee Oh, Jang-Hee Oh, Dong Hun Lee, Dong Hun Lee, Dong Hun Lee, Dong Hun Lee, Soyun Cho, Soyun Cho, Soyun Cho   +17 more
doaj   +1 more source

Renoprotection through PXR–AKR1B7 [PDF]

Nature Reviews Nephrology, 2020
openaire   +2 more sources

Πολυμορφισμοί PXR και καρκίνος

, 2021
Ο υποδοχέας Χ πρεγνανίου (Pregnane X Receptor/PXR) ανήκει στην υπεροικογένεια των πυρηνικών υποδοχέων και κυρίως λειτουργεί ως αισθητήρας ξενοβιοτικών ουσιών και ενεργοποιείται από μια πληθώρα μορίων. Ο PXR εκφράζεται ευρέως σε φυσιολογικούς και κακοήθεις ιστούς. Τα ένζυμα μεταβολισμού φαρμάκων και πρωτεΐνες-μεταφορείς υπόκεινται επίσης υπό την ρύθμιση
openaire   +1 more source

Patchouli alcohol suppresses <i>Helicobacter pylori</i>-associated gastric cancer by activating PXR to inhibit the Wnt/β-catenin pathway and EMT. [PDF]

Front Pharmacol
Zhang X, Zeng Q, Guo P, Xu Y, Ma R, Li J.   +5 more
europepmc   +1 more source

Dexamethasone-Mediated Regulation of CYP3A4 and UGTs in Human Hepatoma HuH-7 Cells. [PDF]

Fundam Clin Pharmacol
Yu H, Lee SH, Kim JH, Kim SJ, Kang HE.
europepmc   +1 more source