Results 71 to 80 of about 13,268 (174)

A review of xenobiotic membrane transporter expression within the human placenta: Lessons gained from primary tissue and in vitro methodologies

The Journal of Physiology, EarlyView.
Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass, Kathryn Wolton, Amanda N. Sferruzzi‐Perri   +2 more
wiley   +1 more source

Integrated Geophysical Imaging Reveals the Origin and Pathways of Mantle‐Derived CO2 Beneath the Tangra Yumco Rift, Central Tibet

Geophysical Research Letters, Volume 53, Issue 11, 16 June 2026.
Abstract The Tangra Yumco Rift (TYR) in central Tibet is a key window for crust–mantle interactions during extension. We performed high‐resolution crust‐mantle imaging using receiver function analysis, 1‐D nonlinear S‐wave velocity inversion, and tomoDD tomography, revealing a vertical Crust–Mantle Degassing System (CMDS) bounded by the Zhala (ZF) and ...
Zongxu Li, Rizheng He, Hanhan Tang, Qiang Xu, Lei Gao, Yulan Li, Lihui Tan, Xiao Niu, Ruo Jia   +8 more
wiley   +1 more source

PXR antagonists and implication in drug metabolism

Drug Metabolism Reviews, 2013
Adopted orphan nuclear receptor (NR), pregnane X receptor (PXR), plays a central role in the regulation of xeno- and endobiotic metabolism. Since the discovery of the functional role of PXR in 1998, there is evolving evidence for the role of PXR agonists in abrogating metabolic pathophysiology (e.g., cholestasis, hypercholesterolemia, and inflammation).
Sridhar, Mani, Wei, Dou, Matthew R, Redinbo   +2 more
openaire   +3 more sources

Activation of nuclear receptor pregnane-X-receptor protects against abdominal aortic aneurysm by inhibiting oxidative stress

Redox Biology
Abdominal aortic aneurysm (AAA) is a life-threatening condition, but effective medications to prevent its progression and rupture are currently lacking. The nuclear receptor pregnane-X-receptor (PXR) plays a crucial role in vascular homeostasis. However,
Zhi Shen, Jinxi Wang, Yifei Chen, Peiliang Fang, Ancai Yuan, Alex F. Chen, Xiaoxiang Yan, Yuyan Lyu, Jun Pu   +8 more
doaj   +1 more source

Generation of a PXR reporter human induced pluripotent stem cell line (PXR-mCherry hiPSC) using the CRISPR/Cas9 system

Stem Cell Research, 2018
Pregnane X receptor (PXR) is a key nuclear receptor that mediates drug metabolism and stimulates hepatocyte proliferation. However, the lack of PXR expression in human pluripotent stem cell-derived hepatocytes limits their application for drug screening ...
Hyemin Kim, Ji-Woo Kim, So-Jin Kim, Young-Jun Choi, Dae-Sung Kim, Han-Jin Park   +5 more
doaj   +1 more source

Transcriptional regulation of mouse PXR gene: an interplay of transregulatory factors. [PDF]

PLoS ONE, 2012
Pregnane X Receptor (PXR) is an important ligand-activated nuclear receptor functioning as a 'master regulator' of expression of phase I, phase II drug metabolizing enzymes, and members of the drug transporters.
Sangeeta Kumari, Gauranga Mukhopadhyay, Rakesh K Tyagi   +2 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, Volume 20, Issue 6, Page 1494-1512, June 2026.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Expression, localization and polymorphisms of the nuclear receptor PXR in Barrett's esophagus and esophageal adenocarcinoma

BMC Gastroenterology, 2011
Background The continuous exposure of esophageal epithelium to refluxate may induce ectopic expression of bile-responsive genes and contribute to the development of Barrett's esophagus (BE) and esophageal adenocarcinoma.
Kusters Johannes G, Siersema Peter D, van Dekken Herman, Pot Raymond GJ, Moons Leon MG, Capello Astrid, Menke Vivianda, van de Winkel Anouk, van der Laan Luc JW, Kuipers Ernst J   +9 more
doaj   +1 more source

Silymarin and Its Isolated Flavanonol Lignans Are Liver X Receptor Antagonists

Archiv der Pharmazie, Volume 359, Issue 6, June 2026.
Despite its long tradition in the treatment of liver‐related ailments, the precise mode of action of the milk thistle fruit extract remains vague. Here we identified liver X receptor as a molecular target of silymarin, a mixture of bioactive compounds from milk thistle extract, and its major flavanonol lignan components, which account for their anti ...
Nils C. Bandomir, Astrid Kaiser, Felix F. Lillich, Pascal Heitel   +3 more
wiley   +1 more source

SUMOylation of pregnane X receptor suppresses rifampicin-induced CYP3A4 and P-gp expression and activity in LS174T cells

Journal of Pharmacological Sciences, 2016
The pregnane X receptor (PXR) has been well-established as a critical mediator in regulating important drug metabolizing enzymes and transporter proteins, including cytochrome P450 3A4 (CYP3A4) and P-glycoprotein (P-gp).
Huasen Tan, Chenshu Xu, Hang Zeng, Ying Wang, Yingmei Li, Xiaomei Fan, Pan Chen, Yiming Jiang, Xiao Chen, Min Huang, Huichang Bi   +10 more
doaj   +1 more source