Results 81 to 90 of about 13,268 (174)

Associations between Pregnane X Receptor and Breast Cancer Growth and Progression

Cells, 2020
Pregnane X receptor (PXR, NR1I2) is a member of the ligand-activated nuclear receptor superfamily. This receptor is promiscuous in its activation profile and is responsive to a broad array of both endobiotic and xenobiotic ligands.
Bradley A. Creamer, Shelly N. B. Sloan, Jennifer F. Dennis, Robert Rogers, Sidney Spencer, Andrew McCuen, Purnadeo Persaud, Jeff L. Staudinger   +7 more
doaj   +1 more source

Induction of cytochrome P450 2C9 and P‐glycoprotein activity by antiseizure medications: A systematic review and network meta‐analysis

Epileptic Disorders, Volume 28, Issue 3, Page 855-867, June 2026.
Abstract Objectives Antiseizure medications (ASMs) can induce the activity of drug‐metabolizing enzymes and drug transporters, including cytochrome P450 (CYP)2C9 and P‐glycoprotein (P‐gp). Our objective was to comparatively assess the effects of ASMs on exposure to clinical CYP2C9 and P‐gp substrates.
Hagar Cohen, Nahawand Bahash, Tomer Ben‐Shushan, Ilan Matok, Sara Eyal   +4 more
wiley   +1 more source

Bile acid metabolism and sleep: Mechanistic interplay and clinical implications of the gut–liver–brain axis

Sleep Research, Volume 3, Issue 2, Page 170-179, June 2026.
Abstract The bidirectional interplay between sleep and metabolic homeostasis is fundamental to physiological health. While the roles of glucose and lipid metabolism in sleep regulation have been extensively characterized, bile acids (BAs), which are traditionally viewed as digestive surfactants, are emerging as critical metabolic messengers with ...
Yu Jiang, Shuangyan Li, Dhirendra Paudel, Miaoqin Tan, Bin Zhang   +4 more
wiley   +1 more source

S-nitrosylation attenuates pregnane X receptor hyperactivity and acetaminophen-induced liver injury

JCI Insight
Drug-induced liver injury (DILI), especially acetaminophen overdose, is the leading cause of acute liver failure. Pregnane X receptor (PXR) is a nuclear receptor and the master regulator of drug metabolism.
Qi Cui, Tingting Jiang, Xinya Xie, Haodong Wang, Lei Qian, Yanyan Cheng, Qiang Li, Tingxu Lu, Qinyu Yao, Jia Liu, Baochang Lai, Chang Chen, Lei Xiao, Nanping Wang   +13 more
doaj   +1 more source

The evolving role of structural biology in pharma: integration of X‐ray crystallography, cryo‐electron microscopy and beyond

Acta Crystallographica Section D, Volume 82, Issue 6, Page 587-602, June 2026.
This review describes how an integrated structural biology platform at Merck Sharp & Dohme LLC, Rahway, New Jersey, USA, combining X‐ray crystallography, cryo‐EM, MicroED and cryo‐ET, enables seamless three‐dimensional insights from molecular to cellular length scales.
Jill E. Chrencik, Hua-Poo Su, Yacob Gomez Llorente, Rachel L. Palte, Daniel J. Klein, Robert P. Hayes, Sadie P. Antine, Guilermo A. Asmar-Rovira, Nicole Bertoletti, Noel J. Byrne, Brittany L. Carroll, Ciro D. Cordeiro, Kaylynn Curfman, James Dutko, Michael J. Eddins, Thierry Fischmann, Barani Govindarajan, Corey W. Hecksel, Thu Ho, Kaspar Hollenstein, Mee Ra Hong, Alan Hruza, Andrii Ishchenko, Maru Jaime-Garza, Matt J. Jaremko, Hayley L. Knox, James Kostas, Harini Krishnamurthy, Ioannis Manolaridis, Cameron L. Noland, Andrea T. Partridge, Sangita B. Patel, Paul Reichert, John C. Reid, Catarina Felisberto-Rodrigues, Chitra A. Shintre, Jennifer M. Shipman, Elakkiya Tamilselvan, Morgan E. Walker, Susanne N. Walker, Renjing Wang, Katharine M. Wright, Tien-Jui Yen, Byung-Kuk Yoo, Sandra B. Gabelli   +44 more
wiley   +1 more source

Flood Hazard Mapping in a Data‐Scarce Urban Watershed Using Analytical Hierarchy Process and Fuzzy Logic: A Case Study of Cuttack, India

Journal of Flood Risk Management, Volume 19, Issue 2, June 2026.
ABSTRACT Floods are among the most frequent and damaging natural hazards in India, particularly affecting low‐lying urban areas in the eastern regions such as Cuttack, Odisha. This study aims to develop a flood hazard susceptibility map for the Cuttack district in Odisha, India, using a combined Analytical Hierarchy Process (AHP) and fuzzy logic ...
Siprarani Pradhan, Surendar Natarajan, Dev Kalyan Panda, Naveen Joseph   +3 more
wiley   +1 more source

Discovery of PXR Antagonist MI891 and PXR Degrader MI1013 and Their Roles in Hepatic Gene Regulation

Journal of Medicinal Chemistry
The pregnane X receptor (PXR) is an important regulator of hepatic metabolism, yet mechanistic insights into the effects of pharmacological inhibition using PXR inverse agonists or antagonists on critical genes involved in both xenobiotic and endobiotic metabolism remain limited.
Rajamanikkam Kamaraj, Ivana Mejdrová, Maria Krutakova, Tomas Smutny, Kryštof Škach, Klara Dohnalova, Lucie Smutna, Dharani Sai Sreekanth Nellore, Jan Dusek, Karel Chalupsky, Jana Hricová, Thales Kronenberger, Aaron Stahl, Markus Templin, Albert Braeuning, Radim Nencka, Petr Pavek   +16 more
openaire   +3 more sources

Ba[C(CN)3]2 and Pb[C(CN)3]2: Two Remarkably Different Heavy Main‐Group Metal Bistricyanomethanides

Zeitschrift für anorganische und allgemeine Chemie, Volume 652, Issue 8, 25 May 2026.
Metathesis reactions of either barium dichloride, BaCl2, or lead dichloride, PbCl2, respectively, with Ag[C(CN)3] in water yielded single crystals of anhydrous Ba[C(CN)3]2 and Pb[C(CN)3]2. Ba[C(CN)3]2 crystallizes in the monoclinic space group P21/n (no. 14) with the lattice parameters a = 437.98(3) pm, b = 1685.36(11) pm, c = 1398.87(9) pm, β = 96.541(
Olaf Reckeweg, Ralf J. C. Locke, Falk Lissner, Lkhamsuren Bayarjargal, David Enseling, Thomas Jüstel, Thomas Schleid   +6 more
wiley   +1 more source

Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer

Molecular Cancer, 2017
Background Although chemotherapy represents a predominant anti-cancer therapeutic modality, drug treatment efficacy is often limited due to the development of resistant tumor cells.
Yan Dong, Zhe Wang, Gan-feng Xie, Chong Li, Wen-wei Zuo, Gang Meng, Cheng-ping Xu, Jian-jun Li   +7 more
doaj   +1 more source

Physiological Functions and Pathological Roles of PXR

Journal of the Endocrine Society
Abstract The pregnane X receptor (PXR, NR1I2), a member of the nuclear receptor superfamily, mainly acts as a ligand-activated transcription factor. PXR is predominantly expressed in the liver and intestines, though it is also present at lower levels in various other tissues.
Kazuhiro Ikeda, Kuniko Horie, Satoshi Inoue, Bruce Blumberg   +3 more
openaire   +3 more sources