Results 1 to 10 of about 97,542 (214)

Pyramidal cell subtype-dependent cortical oscillatory activity regulates motor learning [PDF]

Communications Biology, 2021
Otsuka and Kawaguchi investigate how manipulation of pyramidal cell subtypes in the motor cortex affects cortical network activity. Their findings suggest that pyramidal cell type cell-dependent oscillatory activity play an important role in motor ...
Takeshi Otsuka, Yasuo Kawaguchi
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Differential roles of NaV1.2 and NaV1.6 in neocortical pyramidal cell excitability [PDF]

eLife
Mature neocortical pyramidal cells functionally express two sodium channel (NaV) isoforms: NaV1.2 and NaV1.6. These isoforms are differentially localized to pyramidal cell compartments, and as such are thought to contribute to different aspects of ...
Joshua D Garcia, Chenyu Wang, Ryan PD Alexander, Emmie Banks, Timothy Fenton, Jean-Marc DeKeyser, Tatiana V Abramova, Alfred L George Jr, Roy Ben-Shalom, David H Hackos, Kevin J Bender   +10 more
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Mapping Phosphodiesterase 4D (PDE4D) in Macaque Dorsolateral Prefrontal Cortex: Postsynaptic Compartmentalization in Layer III Pyramidal Cell Circuits [PDF]

Frontiers in Neuroanatomy, 2020
cAMP signaling has powerful, negative effects on cognitive functions of the primate dorsolateral prefrontal cortex (dlPFC), opening potassium channels to reduce firing and impair working memory, and increasing tau phosphorylation in aging neurons.
Dibyadeep Datta, John F. Enwright, Dominique Arion, Constantinos D. Paspalas, Yury M. Morozov, David A. Lewis, Amy F. T. Arnsten   +6 more
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Cadherins orchestrate specific patterns of perisomatic inhibition onto distinct pyramidal cell populations [PDF]

Nature Communications
GABAergic interneurons were thought to regulate excitatory networks by establishing unselective connections onto diverse pyramidal cell populations, but recent studies demonstrate the existence of a cell type-specific inhibitory connectome.
Julie Jézéquel, Giuseppe Condomitti, Tim Kroon, Fursham Hamid, Stella Sanalidou, Teresa Garcés, Patricia Maeso, Maddalena Balia, Zhaohui Hu, Setsuko Sahara, Beatriz Rico   +10 more
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The Molecular Basis for the Calcium-Dependent Slow Afterhyperpolarization in CA1 Hippocampal Pyramidal Neurons

Frontiers in Physiology, 2021
Neuronal signal transmission depends on the frequency, pattern, and timing of spike output, each of which are shaped by spike afterhyperpolarizations (AHPs).
Giriraj Sahu, Ray W. Turner
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Decreased density of pyramidal cells in the cerebral cortex, and Purkinje cells in the cerebellar cortex of Sprague-Dawley rats after being exposed to filtered kretek cigarette smoke

Journal of Biological Research, 2023
Filtered kretek cigarette smoke is a gas that contains solid components (particulates). Carcinogenic chemicals are present in this type of cigarette smoke. Furthermore, it is said that tobacco has a major negative impact on cerebral structure development,
David Tjahyadi, Edy Parwanto, Husnun Amalia, Reza Aditya Digambiro, Hosea Jaya Edy, Ashaolu Victoria Oladimeji   +5 more
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Impaired muscarinic modulation of the rat prelimbic cortex in neuropathic pain is sexually dimorphic and associated with cold allodynia

Frontiers in Cellular Neuroscience, 2023
Cholinergic modulation of the brain cortex is critical for cognitive processes, and altered cholinergic modulation of the prefrontal cortex is emerging as an important mechanism of neuropathic pain.
Taylor Jefferson, Haram R. Kim, Marco Martina   +2 more
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Binary and analog variation of synapses between cortical pyramidal neurons

eLife, 2022
Learning from experience depends at least in part on changes in neuronal connections. We present the largest map of connectivity to date between cortical neurons of a defined type (layer 2/3 [L2/3] pyramidal cells in mouse primary visual cortex), which ...
Sven Dorkenwald, Nicholas L Turner, Thomas Macrina, Kisuk Lee, Ran Lu, Jingpeng Wu, Agnes L Bodor, Adam A Bleckert, Derrick Brittain, Nico Kemnitz, William M Silversmith, Dodam Ih, Jonathan Zung, Aleksandar Zlateski, Ignacio Tartavull, Szi-Chieh Yu, Sergiy Popovych, William Wong, Manuel Castro, Chris S Jordan, Alyssa M Wilson, Emmanouil Froudarakis, JoAnn Buchanan, Marc M Takeno, Russel Torres, Gayathri Mahalingam, Forrest Collman, Casey M Schneider-Mizell, Daniel J Bumbarger, Yang Li, Lynne Becker, Shelby Suckow, Jacob Reimer, Andreas S Tolias, Nuno Macarico da Costa, R Clay Reid, H Sebastian Seung   +36 more
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Pyramidal cells in prefrontal cortex: comparative observations reveal unparalleled specializations in neuronal structure among primate species.

Frontiers in Neuroanatomy, 2011
The most ubiquitous neuron in the cerebral cortex, the pyramidal cell, is characterised by markedly different dendritic structure among different cortical areas. The complex pyramidal cell phenotype in granular prefrontal cortex (gPFC) of higher primates
Guy eElston, Ruth eBenavides-Piccione, Alejandra eElston, Paul eManger, Javier eDefelipe   +4 more
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The subiculum is a patchwork of discrete subregions

eLife, 2018
In the hippocampus, the classical pyramidal cell type of the subiculum acts as a primary output, conveying hippocampal signals to a diverse suite of downstream regions.
Mark S Cembrowski, Lihua Wang, Andrew L Lemire, Monique Copeland, Salvatore F DiLisio, Jody Clements, Nelson Spruston   +6 more
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