Results 21 to 30 of about 97,542 (214)

Cerebellar climbing fibers impact experience-dependent plasticity in the mouse primary somatosensory cortex

eLife
In the cerebellum, climbing fibers (CFs) provide instructive signals for supervised learning at parallel fiber to Purkinje cell synapses. It has not been tested so far whether CF signaling may also influence plasticity in other brain areas. Here, we show
Abby Silbaugh, Kevin P Koster, Christian Hansel   +2 more
doaj   +1 more source

Compartmental distribution of GABA-B receptor-mediated currents along the somato-dendritic axis of hippocampal principal cells

Frontiers in Synaptic Neuroscience, 2015
Activity of cortical principal cells is controlled by the GABAergic system providing inhibition in a compartmentalized manner along their somatodendritic axis.
Claudius Erwin Degro, Akos eKulik, Sam A Booker, Imre eVida, Imre eVida   +4 more
doaj   +1 more source

Grouping and classifying electrophysiologically-defined classes of neocortical neurons by single cell, whole-genome expression profiling

Frontiers in Molecular Neuroscience, 2010
The diversity of neuronal cell types and how to classify them are perennial questions in neuroscience. The advent of global gene expression analysis raised the possibility that comprehensive transcription profiling will resolve neuronal cell types into ...
Tatiana Subkhankulova, Kojiro Yano, Hugh Robinson, Frederick J Livesey   +3 more
doaj   +1 more source

Therapeutic Treatment with Pycnogenol® Attenuates Ischemic Brain Injury in Gerbils Focusing on Cognitive Impairment, Neuronal Death, BBB Leakage and Neuroinflammation in the Hippocampus

Journal of Integrative Neuroscience, 2023
Background: A gerbil model of ischemia and reperfusion (IR) injury in the forebrain has been developed for studies on mechanisms, prevention and therapeutic strategies of IR injury in the forebrain.
Tae-Kyeong Lee, Joon Ha Park, Myoung Cheol Shin, Jun Hwi Cho, Ji Hyeon Ahn, Dae Won Kim, Jae-Chul Lee, Choong-Hyun Lee, Seongkweon Hong, Moo-Ho Won, Il Jun Kang   +10 more
doaj   +1 more source

Histological Study on the Effect of Energy Drinks on the Cerebral Cortex of Adult Male Albino Rats and the Possible Protective Effect of Ashwagandha Extract [PDF]

Zagazig University Medical Journal
Background: Energy drinks are so popular for consumption by athletes and service members. Ashwagandha is a commonly used medical herb. This work aimed to study the effect of energy drinks on the cerebral cortex of adult male albino rats and the possible ...
Nehal El-Helbawy
doaj   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Block Phenomena During Electric Micro-Stimulation of Pyramidal Cells and Retinal Ganglion Cells

Frontiers in Cellular Neuroscience, 2021
Electric micro-stimulation of the nervous system is a means to restore various body functions. The stimulus amplitude necessary to generate action potentials, the lower threshold (LT), is well characterized for many neuronal populations.
Sogand Sajedi, Andreas Fellner, Paul Werginz, Frank Rattay   +3 more
doaj   +1 more source

Comprehensive Characterization of 98 Chinese Cases of Genetic Creutzfeldt‐Jakob Disease With T188K Mutation

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize the demographic, clinical, and laboratory features of the Chinese patients of genetic Creutzfeldt‐Jakob disease with T188K variant (T188K‐gCJD), the most common subtype of genetic prion diseases (gPrDs) in China. Methods In this nationwide retrospective study, data from 98 genetically confirmed T188K‐gCJD patients ...
Chun‐Jie Li, Dong‐Lin Liang, Li‐Ping Gao, Wei‐Wei Zhang, Wei Zhou, A. Ruhan, Bing Xu, Run‐Dong Cao, Kang Xiao, Cao Chen, Qi Shi, Xiao‐Ping Dong   +11 more
wiley   +1 more source

Accelerated signal propagation speed in human neocortical dendrites

eLife
Human-specific cognitive abilities depend on information processing in the cerebral cortex, where the neurons are significantly larger and their processes longer and sparser compared to rodents.
Gáspár Oláh, Rajmund Lákovics, Sapir Shapira, Yonatan Leibner, Attila Szücs, Éva Adrienn Csajbók, Pál Barzó, Gábor Molnár, Idan Segev, Gábor Tamás   +9 more
doaj   +1 more source

Modulation of medial prefrontal cortical activity using in vivo recordings and optogenetics

Molecular Brain, 2012
Background The medial prefrontal cortex (mPFC) serves major executive functions. mPFC output to subcortical brain areas such as the amygdala controls emotional processing and plays an important role in fear extinction.
Ji Guangchen, Neugebauer Volker
doaj   +1 more source