Results 1 to 10 of about 20,891 (238)

Facile One-Pot Multicomponent Synthesis of Pyrazolo-Thiazole Substituted Pyridines with Potential Anti-Proliferative Activity: Synthesis, In Vitro and In Silico Studies

Molecules, 2021
Pyrazolothiazole-substituted pyridine conjugates are an important class of heterocyclic compounds with an extensive variety of potential applications in the medicinal and pharmacological arenas.
Islam H. El Azab, Rania B. Bakr, Nadia A. A. Elkanzi   +2 more
doaj   +1 more source

Clean One-Pot Multicomponent Synthesis of Pyrans Using a Green and Magnetically Recyclable Heterogeneous Nanocatalyst

SynOpen, 2021
Copper ferrite (CuFe2O4) magnetic nanoparticles (MNPs) were synthesized via thermal decomposition and applied as a reusable and green catalyst in the synthesis of functionalized 4H-pyran derivatives using malononitrile, an aromatic aldehyde, and a β ...
Mina Ghassemi, Ali Maleki
doaj   +1 more source

A Facile and Highly Efficient Three Component Synthesis of Pyran and Chromene Derivatives in the Presence of Nano SnO2 as a catalyst [PDF]

شیمی کاربردی روز, 2015
Nano tin dioxide was employed as a catalyst for efficient and facile preparation of pyran derivatives via the one-pot three component condensation reaction of various aldehydes with malononitrile and dimedone.
سید محمد وحدت, مریم خاورپور, فرج اله محمدزاده   +2 more
doaj   +1 more source

Novel Pyran-Linked Phthalazinone-Pyrazole Hybrids: Synthesis, Cytotoxicity Evaluation, Molecular Modeling, and Descriptor Studies

Frontiers in Chemistry, 2021
A series of novel pyran-linked phthalazinone-pyrazole hybrids were designed and synthesized by a facile one-pot three-component reaction employing substituted phthalazinone, 1H-pyrazole-5-carbaldehyde, and active methylene compounds. Optimization studies
M. Shaheer Malik, Basim H. Asghar, Riyaz Syed, Reem I. Alsantali, Moataz Morad, Hatem M. Altass, Hatem M. Altass, Ziad Moussa, Ismail I. Althagafi, Rabab S. Jassas, Saleh A. Ahmed, Saleh A. Ahmed   +11 more
doaj   +1 more source

Multi-component Reactions of Cyclohexan-1,3-diketones to Produce Fused Pyran Derivatives with Antiproliferative Activities and Tyrosine Kinases and Pim-1 Kinase Inhibitions

Acta Chimica Slovenica, 2021
In this work the multi-component reactions of either of the arylhydrazocyclohexan-1,3-dione derivatives 3a–c with either of benzaldehyde (4a), 4-chlorobenzaldehyde (4b) or 4-methoxybenzaldehyde (4c) and either malononitrile (5a) or ethyl cyanoacetate (5b)
Rafat M Mohareb, Rehab Ali Ibrahim, Ensaf Sultan Alwan   +2 more
doaj   +1 more source

Ethyl 2,2-dimethyl-4-oxo-6-phenyl-3,4-dihydro-2H-pyran-5-carboxylate

IUCrData, 2016
The title compound, C16H18O4, is a derivative of 3,4-dihydro-2H-pyran-4-one. The plane of the pyranone ring system forms a dihedral angle of 42.76 (10)° with that of the phenyl group.
N. Sharmila, T. V. Sundar, P. Sakthivel, P. Venkatesan   +3 more
doaj   +1 more source

Methyl (6R*,6aR*,12bR*)-2,4-dimethyl-6-(2-methylphenyl)-1,3-dioxo-2,3,4,6a,7,12b-hexahydro-1H,6H-chromeno[4′,3′:4,5]pyrano[2,3-d]pyrimidine-6a-carboxylate

IUCrData, 2017
In the title compound, C24H24N2O6, the mean planes of the pyran rings (A and B) are inclined to one another by 69.2 (1)°, while the aromatic ring (D) of the chromene ring system makes dihedral angles of 63.42 (11) and 66.81 (12)° with the pyrimidine (C ...
S. Gomathi, Era Dravida Thendral, G. Sivakumar, V. Sabari, G. Usha   +4 more
doaj   +1 more source

The crystal structures of two new coumarin derivatives: 2-(4-{2-[(2-oxo-2H-chromen-4-yl)oxy]acetyl}piperazin-1-yl)acetamide and N-(2,4-dimethoxybenzyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide

Acta Crystallographica Section E: Crystallographic Communications, 2019
The title compounds, 2-(4-{2-[(2-oxo-2H-chromen-4-yl)oxy]acetyl}piperazin-1-yl)acetamide, C17H19N3O5, (I), and N-(2,4-dimethoxybenzyl)-2-[(2-oxo-2H-chromen-4-yl)oxy]acetamide, C20H19NO6, (II), are new coumarin derivatives.
S. Syed Abuthahir, M. NizamMohideen, V. Viswanathan, M. Govindhan, K. Subramanian   +4 more
doaj   +1 more source

Crystal structure, DFT and Hirshfeld surface analysis of 2-amino-4-(2-chlorophenyl)-7-hydroxy-4H-benzo[1,2-b]pyran-3-carbonitrile

Acta Crystallographica Section E: Crystallographic Communications, 2019
The benzopyran ring of the title compound, C16H11ClN2O2, is planar [maximum deviation = 0.079 (2) Å] and is almost perpendicular to the chlorophenyl ring [dihedral angle = 86.85 (6)°]. In the crystal, N—H...O, O—H...N, C—H...O and C—H...Cl hydrogen bonds
M. Beemarao, S. Silambarasan, A. Jamal Abdul Nasser, M. Purushothaman, K. Ravichandran   +4 more
doaj   +1 more source

The Search for Natural Inhibitors of Biofilm Formation and the Activity of the Autoinductor C6-AHL in Klebsiella pneumoniae ATCC 13884

Biomolecules, 2019
Human nosocomial infections are common around the world. One of the main causes is the bacteria Klebsiella pneumoniae, which shows high rates of resistance to antibiotics. Thus, drugs with novel mechanisms of action are needed.
Elizabeth Cadavid, Fernando Echeverri
doaj   +1 more source