Results 41 to 50 of about 22,717 (244)

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Computational and Experimental Investigation of the Diels−Alder Cycloadditions of 4-Chloro-2(H)-pyran-2-one^†

, 2016
4-Chloro-2(H)-pyran-2-one undergoes thermal Diels−Alder cycloaddition with electron-deficient dienophiles to afford, without any significant selectivity, 6-endo- and 5-endo-substituted bicyclic lactone cycloadducts.
Michael J. Bearpark (1594144), Alexis Ndibwami (2692774), Kamyar Afarinkia (473836)   +2 more
core   +1 more source

Uses of 3-(2-Bromoacetyl)-2H-chromen-2-one in the Synthesis of Heterocyclic Compounds Incorporating Coumarin: Synthesis, Characterization and Cytotoxicity

Molecules, 2015
In this work, 3-bromoacetylcoumarin was used as the key starting material for the synthesis of pyran, pyridine, thiophene, thiazole and pyrazole derivatives through its reaction with different reagents.
Rafat M. Mohareb, Nadia Y. MegallyAbdo
doaj   +1 more source

Molecular Atlas of Key Food Odorants Reveals Mixture‐Level Organization and Enables Generative Aroma Design

Advanced Science, EarlyView.
KFO‐Atlas reveals how real‐world aromas are organized as structured mixtures rather than individual molecules. Building on these principles, KFO‐Gen, a generative AI framework, designs perceptually valid aroma formulations and reconstructs meat‐like aromas exclusively from plant‐derived odorants, providing a foundation for mixture‐level studies and AI ...
Jingzhi Zhang, Huadong Xing, Antonella Di Pizio, Qinfei Ke, Xingran Kou, Dachuan Zhang   +5 more
wiley   +1 more source

Synthesis and ¹H NMR data assignment of 3-acetamido-4-amino-3,4-dihydro-2H-pyran-6-carboxylates and their acetyl-migrated isomers

, 2021
An unexpected acetyl migration is found in the product of Staudinger reduction to prepare the 4(R)-epimer of zanamivir and laninamivir octanoate as the impurity of drug substance.
Chuanqi Duan (11277898), Weiyuan Liu (6637607), Weicheng Zhou (1652359), Yubin Liu (2835542), Jing Pan (95938), Kuaile Lin (1652362), Liang Chen (73736)   +6 more
core   +1 more source

Synthesis, Anti-Inflammatory, and Molecular Docking Studies of New Heterocyclic Derivatives Comprising Pyrazole, Pyridine, and/or Pyran Moieties

Pharmaceuticals
Introduction: Inhibiting cyclooxygenase-2 (COX-2) is a potential strategy in inflammation therapy. Thus, developing COX-2 inhibitors plays a pivotal role in efficient inflammation treatment.
Mohamed A. M. Abdel Reheim, Hend S. Abdel Rady, Omnia A. Mohamed, Abdelfattah Hassan, Ibrahim S. Abdel Hafiz, Hala M. Reffat, Fahmy Gad Elsaid, Mamdouh Eldesoqui, Dalal Sulaiman Alshaya, Abdelnaser A. Badawy, Eman Fayad, Aboubakr H. Abdelmonsef   +11 more
doaj   +1 more source

Allyl 6-amino-4-(4-chlorophenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate

IUCrData, 2019
In the title compound, C17H15ClN2O3, the 4H-pyran ring exhibits a shallow-boat conformation and the chlorobenzene ring occupies an axial position. The O-allyl side chain is disordered over two orientations in a 0.585 (14):0.415 (14) ratio. In the crystal,
G. Anantha Krishnan, T. Mohandas, C. Udhaya Kumar, M. Velayutham Pillai, P. Sakthivel   +4 more
doaj   +1 more source

Beyond Conventional: A Review of Phytochemical‐Hydrogel Systems Enhanced by AI and 3D Printing for Chronic Wound Management

Advanced Science, EarlyView.
This review systematically bridges chronic wound pathology with natural phytochemical hydrogel therapeutics. A pathology‐to‐phytochemical mechanistic mapping framework is established, linking specific wound hallmarks to targeted phytochemical interventions.
Yitao Zhou, Xing Liu, Cuiyi Wang, Xiaoxuan Zhao, Pengrun Zhang, Jingjing Gu, Qiuhua Sun, Malcolm Xing, Yeqin Yang   +8 more
wiley   +1 more source

Nucleophilic Substitution by a Hydroxide Ion at a Vinylic Carbon:  Ab Initio and Density Functional Theory Studies on Methoxyethene, 3-Methoxypropenal, 2,3-Dihydro-4H-pyran-4-one, and 4H-Pyran-4-one

, 2016
Nucleophilic substitutions by a hydroxide ion at vinylic carbons of methoxyethene (system A), 3-methoxypropenal (system B), 2,3-dihydro-4H-pyran-4-one (system C), and 4H-pyran-4-one (system D) were calculated by Becke's three-parameter hybrid density ...
Pavol Zahradník (3026718), Walter M. F. Fabian (1852501), Juraj Kóňa (3026715)   +2 more
core   +1 more source

The crystal structures of 6′-(4-chlorophenyl)- and 6′-(4-methoxyphenyl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexahydro-2H,6′H,8′H-spiro[acenaphthylene-1,12′-chromeno[3,4-a]indolizin]-2-one

Acta Crystallographica Section E: Crystallographic Communications, 2019
In the title compounds, C32H25ClN2O4 (I) and C33H28N2O5 (II), the six-membered pyran and piperidine rings adopt envelope and chair conformations, respectively. The five-membered pyrrolidine rings adopt twist conformations. Compound (II) crystallizes with
S. Syed Abuthahir, M. NizamMohideen, V. Viswanathan, D. Velmurugan, J. Nagasivarao   +4 more
doaj   +1 more source