Modeling Pyran Formation in the Molybdenum Cofactor: Protonation of Quinoxalyl–Dithiolene Promoting Pyran Cyclization [PDF]
Inorganic Chemistry, 2019 Mononuclear Mo and W enzymes require a unique ligand known as molybdopterin (MPT). This ligand binds the metal through a dithiolene chelate, and the dithiolene bridges a reduced pyranopterin group. Pyran scission and formation have been proposed as a reaction of the MPT ligand that may occur within the enzymes to adjust reactivity at the Mo atom.
Douglas R. Gisewhite +4 more
core +7 more sources
6-Unsubstituierte 2H-Pyran-2-one Synthese und Reaktivität [PDF]
CHIMIA, 1992 Although the 2H-pyran-2-ones have been known for more than 100 years, their importance as versatile intermediates was not widely recognized before the sixties of this century.
Vratislav Kvita, Walter Fischer
doaj +5 more sources
Scheme 1, Synthesis of fluorinated chalcones (1–20) and their 2-amino-pyridine-3-carbonitrile (21–40) and 2-amino-4H-pyran-3-carbonitrile (41–60) derivatives. [PDF]
, 2022 Scheme 1, Synthesis of fluorinated chalcones (1–20) and their 2-amino-pyridine-3-carbonitrile (21–40) and 2-amino-4H-pyran-3-carbonitrile (41–60) derivatives.
M. Mukhlesur Rahman (2100193) +7 more
core +1 more source
Summary of the antitubercular activities of fluorinated chalcones (1–20), 2-amino-pyridine-3-carbonitrile (21–40) and 2-amino-4H-pyran-3-carbonitrile (41–60) derivatives. [PDF]
, 2022 Summary of the antitubercular activities of fluorinated chalcones (1–20), 2-amino-pyridine-3-carbonitrile (21–40) and 2-amino-4H-pyran-3-carbonitrile (41–60) derivatives.
M. Mukhlesur Rahman (2100193) +7 more
core +1 more source
Diastereoselective Construction of Tetrahydro-Dispiro[indolinone-3,2′-pyran-5′,4″-pyrazolone] Scaffolds via an Oxa-Michael Cascade [4 + 2] Annulation Reaction [PDF]
, 2022 A straightforward metal-free oxa-Michael cascade [4 + 2] annulation reaction was established between isatin-derived Morita–Baylis–Hillman (Is-MBH) alcohols with alkylidene pyrazolones to access structural diverse tetrahydro-dispiro[indolinone-3,2′-pyran ...
Venkitasamy Kesavan (1643218) +2 more
core +1 more source
Structure activity relationships of fluorinated chalcones (1–20), 2-amino-pyridine-3-carbonitrile (21–40) and 2-amino-4H-pyran-3-carbonitrile (41–60) derivatives. [PDF]
, 2022 Structure activity relationships of fluorinated chalcones (1–20), 2-amino-pyridine-3-carbonitrile (21–40) and 2-amino-4H-pyran-3-carbonitrile (41–60) derivatives.
M. Mukhlesur Rahman (2100193) +7 more
core +1 more source
Synthesis and 1H NMR data assignment of 3-acetamido-4-amino-3,4-dihydro-2H-pyran-6-carboxylates and their acetyl-migrated isomers [PDF]
, 2021 An unexpected acetyl migration is found in the product of Staudinger reduction to prepare the 4(R)-epimer of zanamivir and laninamivir octanoate as the impurity of drug substance.
Chuanqi Duan (11277898) +6 more
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5-(Trimethylstannyl)-2H-pyran-2-one and 3-(Trimethylstannyl)-2H-pyran-2-one: New 2H-Pyran-2-one Synthons [PDF]
, 2016 5-(Trimethylstannyl)-2H-pyran-2-one (11) and 3-(trimethylstannyl)-2H-pyran-2-one (30), readily prepared from the corresponding bromo-2H-pyran-2-ones, undergo Pd(0)-catalyzed coupling reactions with a variety of enol triflates to give 5- and 3 ...
Zhi Liu (165121) +1 more
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Computational and Experimental Investigation of the Diels−Alder Cycloadditions of 4-Chloro-2(H)-pyran-2-one† [PDF]
, 2016 4-Chloro-2(H)-pyran-2-one undergoes thermal Diels−Alder cycloaddition with electron-deficient dienophiles to afford, without any significant selectivity, 6-endo- and 5-endo-substituted bicyclic lactone cycloadducts.
Michael J. Bearpark (1594144) +2 more
core +1 more source
, 2021 The diastereoselective domino-Knoevenagel-IMHDA reactions of 5,6-dihydro-2H-pyran derivatives containing an o-formylaryl amine or ether moiety were performed with active methylene reagents. In the spiro heterocyclic products representing a novel skeleton,
Sándor Balázs Király +11 more
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