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A quantitative adaptation of the Wayne test for pyrazinamide resistance [PDF]
Tuberculosis, 2016 Pyrazinamide (PZA) is the most important drug against the latent stage of tuberculosis (TB) and is used in both first and second line treatment regimens. The continued increase in multi-drug resistant TB and the prevalence of PZA resistance makes the development of alternative assays for prompt identification of PZA resistance all the more important.We
Alvaro Proano +2 more
exaly +6 more sources
Genotypic characterization of pyrazinamide resistance in Mycobacterium tuberculosis isolated from Lusaka, Zambia [PDF]
Tuberculosis, 2018 Pyrazinamide forms a core part of treatment for all types of tuberculosis (TB) in Zambia. Due to challenges associated with pyrazinamide testing, little information is available to indicate the frequency of resistance to this drug in Zambia. To determine
Precious Bwalya, Yasuhiko Suzuki
exaly +3 more sources
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Prevalence of Pyrazinamide Resistance in Khyber Pakhtunkhwa, Pakistan
Microbial Drug Resistance, 2018Aims: Pyrazinamide (PZA) is an important component of first-line tuberculosis (TB) treatment because of its distinctive capability to kill subpopulations of persister Mycobacterium tuberculosis (MTB).
Muhammad Tahir Khan +2 more
exaly +3 more sources
Pyrazinamide resistance in Mycobacterium tuberculosis: Review and update
Advances in Medical Sciences, 2016The global control and management of tuberculosis (TB) is faced with the formidable challenge of worsening scenarios of drug-resistant disease. Pyrazinamide (PZA) is an indispensable first-line drug used for the treatment of TB. It plays a key role in reducing TB relapse rates, shortening the course of the disease treatment from 9-12 months to 6 months,
Moses, Njire +7 more
openaire +2 more sources
Prevalence of pyrazinamide resistance across the spectrum of drug resistant phenotypes of Mycobacterium tuberculosis [PDF]
Tuberculosis, 2016 : Pyrazinamide resistance is largely unknown in the spectrum of drug resistant phenotypes. We summarize data on PZA resistance in clinical isolates from South Africa.
Michael G Whitfield +2 more
exaly +3 more sources
A simple way of detecting pyrazinamide resistance
Tubercle, 1972Abstract The reason for the growth of some M. tuberculosis strains on the nicotinamide containing Lowenstein-Jensen medium of pH 7 in the Tan Thiam Hok's test was related to their pyrazinamide resistance. The method was adapted for testing the pyrazinamide sensitivity of M. tuberculosis strains instead of the old methods with acid pH.
openaire +2 more sources
Potentiometric method for resistance's measurement of pyrazinamide in mycobacterium tuberculosis
5th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics, 2014An experimental research of the drug pyrazinamide is analyzed and tested with potentiometric method. By understanding the biomechatronic system, consisted of a mechanism of action of the drug Pyrazinamide in a biological system, and an electrical signals, voltametric measures, a method to detect resistance to this specific drug is developed and tested ...
Furukawa, Roberto +4 more
openaire +1 more source
Structural dynamics behind variants in pyrazinamidase and pyrazinamide resistance
Journal of Biomolecular Structure and Dynamics, 2019Pyrazinamide (PZA) is an important component of first-line anti-tuberculosis (anti-TB) drugs. The anti-TB agent is activated into an active form, pyrazinoic acid (POA), by Mycobacterium tuberculosis (MTB) pncA gene encoding pyrazinamidase (PZase). The major cause of PZA-resistance has been associated with mutations in the pncA gene.
Muhammad Tahir, Khan +1 more
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Selection of in vitro mutants of pyrazinamide-resistant Mycobacterium tuberculosis
International Journal of Antimicrobial Agents, 2002Mutations within the pncA gene coding for pyrazinamidase of Mycobacterium tuberculosis can cause pyrazinamide (PZA) resistance. The effect of drug concentrations on PZA resistance in a clinical isolate of M. tuberculosis was studied in vitro. Serial passage at gradually increased concentrations of PZA from 200 to 500 microg/ml was performed using ...
M, Bamaga, D J M, Wright, H, Zhang
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Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis
Antimicrobial Agents and Chemotherapy, 1997Pyrazinamide (PZA) is a first-line drug for short-course tuberculosis therapy. Resistance to PZA is usually accompanied by loss of pyrazinamidase (PZase) activity in Mycobacterium tuberculosis. PZase converts PZA to bactericidal pyrazinoic acid, and the loss of PZase activity is associated with PZA resistance.
A, Scorpio +6 more
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