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Fluoroquinolone and pyrazinamide resistance in multidrug-resistant tuberculosis.
The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease, 2012In a study performed in Cambodia, a higher number of tuberculosis (TB) strains with mutations in the pncA gene associated with pyrazinamide resistance (PZA-R) was found in fluoroquinolone-resistant (FQ-R) multidrug-resistant (MDR) strains (93%), compared with 47% in MDR and 3% in non-MDR strains.
C, Pierre-Audigier +7 more
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Characterization of pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis
Antimicrobial Agents and Chemotherapy, 1997Pyrazinamide (PZA) is a first-line drug for short-course tuberculosis therapy. Resistance to PZA is usually accompanied by loss of pyrazinamidase (PZase) activity in Mycobacterium tuberculosis. PZase converts PZA to bactericidal pyrazinoic acid, and the loss of PZase activity is associated with PZA resistance.
A, Scorpio +6 more
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No evidence that pyrazinamide resistance is acquired after fluoroquinolone resistance
The International Journal of Tuberculosis and Lung Disease, 2016Cobelens, Frank +2 more
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Resistance of Mycobacterium tuberculosis isolates to pyrazinamide and fluoroquinolones
The Lancet Infectious Diseases, 2017Ling, Chen, Hong, Zhang
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Genotypic characterization of pyrazinamide resistance in isolated from Lusaka, Zambia
Tuberculosis, 2018Yukari Fukushima +2 more
exaly
Resistance to pyrazinamide in Russian isolates: sequencing versus Bactec MGIT 960
Tuberculosis, 2015Kirill V Shur +2 more
exaly
[Resistance to pyrazinamide in tuberculosis patients].
Enfermedades infecciosas y microbiologia clinica, 1991M, Casal, M J, Linares, N, Marín
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