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Open-access genomic drug resistance prediction tools for <i>Mycobacterium tuberculosis</i>: a systematic review and meta-analysis. [PDF]

J Clin Microbiol
Dewaele K, Jouego C, Asim A, Laenen L, Meehan C, André E.   +5 more
europepmc   +1 more source

A quantitative adaptation of the Wayne test for pyrazinamide resistance

Tuberculosis, 2016
Pyrazinamide (PZA) is the most important drug against the latent stage of tuberculosis (TB) and is used in both first and second line treatment regimens. The continued increase in multi-drug resistant TB and the prevalence of PZA resistance makes the development of alternative assays for prompt identification of PZA resistance all the more important.We
Alvaro Proaño, Jorge Coronel, Patricia Sheen   +2 more
exaly   +6 more sources

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Pyrazinamide resistance in Mycobacterium tuberculosis: Review and update

Advances in Medical Sciences, 2016
The global control and management of tuberculosis (TB) is faced with the formidable challenge of worsening scenarios of drug-resistant disease. Pyrazinamide (PZA) is an indispensable first-line drug used for the treatment of TB. It plays a key role in reducing TB relapse rates, shortening the course of the disease treatment from 9-12 months to 6 months,
Moses, Njire, Yaoju, Tan, Julius, Mugweru, Changwei, Wang, Jintao, Guo, WingWai, Yew, Shouyong, Tan, Tianyu, Zhang   +7 more
openaire   +2 more sources

Prevalence of Pyrazinamide Resistance in Khyber Pakhtunkhwa, Pakistan

Microbial Drug Resistance, 2018
Aims: Pyrazinamide (PZA) is an important component of first-line tuberculosis (TB) treatment because of its distinctive capability to kill subpopulations of persister Mycobacterium tuberculosis (MTB).
Muhammad Tahir, Khan, Shaukat Iqbal, Malik, Sajid, Ali, Anwar, Sheed Khan, Tariq, Nadeem, Muhammad Tariq, Zeb, Nayyer, Masood, Muhammad Tanvir, Afzal   +7 more
openaire   +2 more sources

A simple way of detecting pyrazinamide resistance

Tubercle, 1972
Abstract The reason for the growth of some M. tuberculosis strains on the nicotinamide containing Lowenstein-Jensen medium of pH 7 in the Tan Thiam Hok's test was related to their pyrazinamide resistance. The method was adapted for testing the pyrazinamide sensitivity of M. tuberculosis strains instead of the old methods with acid pH.
openaire   +2 more sources

Pyrazinamide resistance in Mycobacterium tuberculosis arises after rifampicin and fluoroquinolone resistance

International Journal of Tuberculosis and Lung Disease, 2015
Multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains of Mycobacterium tuberculosis (TB) constitute a major public health concern.To determine the timing of pncA mutations that confer pyrazinamide (PZA) resistance in relation to mutations conferring resistance to isoniazid (INH) and rifampicin (RMP).Isolates from two major urban ...
Brigitte Gicquel
exaly   +4 more sources

Structural dynamics behind variants in pyrazinamidase and pyrazinamide resistance

Journal of Biomolecular Structure and Dynamics, 2019
Pyrazinamide (PZA) is an important component of first-line anti-tuberculosis (anti-TB) drugs. The anti-TB agent is activated into an active form, pyrazinoic acid (POA), by Mycobacterium tuberculosis (MTB) pncA gene encoding pyrazinamidase (PZase). The major cause of PZA-resistance has been associated with mutations in the pncA gene.
Muhammad Tahir, Khan, Shaukat Iqbal, Malik   +1 more
openaire   +2 more sources

Potentiometric method for resistance's measurement of pyrazinamide in mycobacterium tuberculosis

5th IEEE RAS/EMBS International Conference on Biomedical Robotics and Biomechatronics, 2014
An experimental research of the drug pyrazinamide is analyzed and tested with potentiometric method. By understanding the biomechatronic system, consisted of a mechanism of action of the drug Pyrazinamide in a biological system, and an electrical signals, voltametric measures, a method to detect resistance to this specific drug is developed and tested ...
Furukawa, Roberto, Rueda, Daniel, Zimic-Peralta, Mirko Juan, IEEE Engineering in Medicine and Biology Society (EMBS), IEEE Robotic and Automation Society (RAS)   +4 more
openaire   +1 more source

Pyrazinamide Resistance in Multidrug-Resistant Strains ofMycobacterium tuberculosisIsolated in Abkhazia

Journal of Chemotherapy, 2007
The emergence of multidrug-resistant (MDR) Mycobacterium tuberculosis (Mtb) strains, i.e. strains resistant at least to isoniazid (INH) and rifampin (RMP), the two most powerful first-line drugs for the treatment of tuberculosis (TB), represents a worldwide health care problem.
Pardini M., Varaine F., Hewison C., Iona E., Pataracchia M., Orefici G., Fattorini L., Oggioni M. R., Meacci F., D'Amato V., Andrew P. W., Barer M., Yesilkaya H., Rinder H., Rusch-Gerdes S., Niemann S., Orru G., Varaine F., Bonnet M., Jarosz T.   +19 more
openaire   +2 more sources

Selection of in vitro mutants of pyrazinamide-resistant Mycobacterium tuberculosis

International Journal of Antimicrobial Agents, 2002
Mutations within the pncA gene coding for pyrazinamidase of Mycobacterium tuberculosis can cause pyrazinamide (PZA) resistance. The effect of drug concentrations on PZA resistance in a clinical isolate of M. tuberculosis was studied in vitro. Serial passage at gradually increased concentrations of PZA from 200 to 500 microg/ml was performed using ...
M, Bamaga, D J M, Wright, H, Zhang
openaire   +2 more sources