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Synthesis of Novel Tetra-Substituted Pyrazole Derivatives Using Microwave Irradiation and Their Anti-Leukemic Activity Against Jurkat Cells. [PDF]
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Synthesis of pyrazoles and condensed pyrazoles
Journal of Heterocyclic Chemistry, 1999AbstractThis review introduces the synthesis of various pyrazoles reported by us and some other research groups during 1989–1998. Some of papers in this review deal with the development of potent pyrazoles or with the synthesis of potential pyrazoles aiming at agrochemicals and/or drugs.
Kenzi Makino +2 more
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Pyrazoles. III. PMR studies of pyrazoles
Recueil des Travaux Chimiques des Pays-Bas, 1967AbstractSubstituents with electron withdrawing capacities are found to induce a paramagnetic displacement of the chemical shifts of protons and methyl groups in the remaining positions of the pyrazole ring. For the 4‐position this effect is considered to be due primarily to resonance interaction of substituent and pyrazole ring.
Clarisse L. Habraken +2 more
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Pyrazole: preclinical reassessment
Investigational New Drugs, 1988Pyrazole (NSC-45410) is a low molecular weight, heterocyclic compound which has been considered for reevaluation in the clinic as a potential cytotoxic agent (Fig. 1). Discovered in 1893, pyrazole is best known as an inhibitor of liver alcohol dehydrogenase (ki = 0.2 uM), and as a result, has been used extensively in studies of alcohol metabolism.
P J, O'Dwyer +5 more
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Pyrazole–coumarin and pyrazole–quinoline chalcones as potential antitubercular agents
Archiv der Pharmazie, 2020AbstractPyrazole, coumarin, and quinoline are medicinally important moieties. In this study, two series of novel pyrazole–coumarin chalcones and pyrazole–quinoline chalcones were synthesized using multiple‐step reactions. All the synthesized compounds were well characterized using different spectroscopic techniques including 1H and 13C nuclear magnetic
Gautam Kumar +3 more
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ChemInform Abstract: Synthesis of Pyrazoles and Condensed Pyrazoles
ChemInform, 1999AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Kenzi Makino +2 more
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Pyrazole analogues of prazosin
Il Farmaco, 1998A series of analogues of prazosin, in which 1-methyl or 1-phenylpyrazole moieties were substituted for the furan ring, were synthesized and studied for their alpha 1-adrenoceptor antagonist activity. The role of the five member heterocyclic substructures in determining the affinity for the alpha 1-receptor is briefly discussed.
ERMONDI, Giuseppe +4 more
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