Results 211 to 220 of about 64,409 (320)

Inhibition of dopamine‐β‐hydroxylase by a metabolite of pyrazole, 4‐hydroxypyrazole, in vitro [PDF]

, 1980
Jaakko Pispa, Ewen MacDonald
openalex   +1 more source

Targeting G9a decreases escalated alcohol drinking in male mice in a model of combined stress and chronic alcohol exposure

Alcohol, Clinical and Experimental Research, EarlyView.
Targeting dependence‐ and/or stress‐escalated alcohol drinking could help patients with alcohol use disorder (AUD). We found that reducing the activity of the epigenetic regulatory enzyme G9a (aka euchromatic histone‐lysine N‐methyltransferase 2 or EHMT2) either by a viral knockdown in the nucleus accumbens (NAc) or by repeated systemic administration ...
Marcelo F. Lopez, Paulina Misztak, Howard C. Becker, Christopher W. Cowan, Ethan M. Anderson   +4 more
wiley   +1 more source

Crystal structure and Hirshfeld surface analysis of 5-(3-nitro-1<i>H</i>-pyrazol-4-yl)-1<i>H</i>-tetra-zole. [PDF]

Acta Crystallogr E Crystallogr Commun
Creegan SE, Ridenour JA, Caruana PA, Giles ID, Kerr AT.   +4 more
europepmc   +1 more source

Syntheses of [1]Benzopyrano[4,3-c]pyrazoles and -[3,4-d]isoxazoles [PDF]

, 1981
Tomio Shimizu, Y. Hayashi, Kazunari Yamada, Toshiyuki Nishio, Kazuhiro Teramura   +4 more
openalex   +1 more source

Plasma apolipoproteins and memory function in alcohol use disorder: Findings in male C57BL/6J mice and men suggest a role for APOAI

Alcohol, Clinical and Experimental Research, EarlyView.
Both alcohol‐dependent mice and abstinent AUD patients exhibited elevated plasma APOAI levels and memory impairments compared to controls. Higher APOAI levels were associated with poorer memory in both species, suggesting its potential as a biomarker for alcohol‐related cognitive deficits.
Berta Escudero, Max Kreifeldt, Kiera Fleck, Catherine Lopez, Candice Contet, Laura Orio   +5 more
wiley   +1 more source

Biocatalytic Alkylation of Ambident Nucleophiles Enables Selective N‐Functionalization of Heterocycles and Late‐Stage Modifications

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
N‐alkylated heteroarenes are key structural motifs in bioactive compounds, but their regioselective synthesis via coupling of readily available azoles with haloalkanes remains very challenging. Here, we present a mild biocatalytic approach that proceeds on gram‐scale, is highly chemo‐ and regioselective, offering rapid access to valuable N‐alkylated ...
Felipe Ospina, Kai H. Schülke, Marius Schnutenhaus, Alina Klein, Om Desai, Shubhanshu Jain, Christine Krofta, Lukas Stratmann, Jianing Yang, Harald Gröger, Stephan C. Hammer   +10 more
wiley   +2 more sources

Synthesis of novel trans-2,3-dihydrofuran-pyrazole conjugates through molecular hybridization: molecular docking insights and evaluation of anti-inflammatory and anti-malarial activities. [PDF]

BMC Chem
Kumari G, Rani P, Dhillon S, Chahal M, Kumar B, Devi J, Aneja DK, Kinger M.   +7 more
europepmc   +1 more source

Structures and Spectral Properties of Some Bis(β-diketonato)copper(II)Diazole Complexes. I. The 1:4 and 1:1 Adducts of Bis(1,1,1,5,5,5-hexafluoro-2,4-pentanedionato)copper(II) and 3-Methyl-1H-pyrazole [PDF]

, 1989
Tamizo Kogane, Minoru Ishii, Kazumasa Harada, Reiko Hirota, Masayoshi Nakahara   +4 more
openalex   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Privileged Chiral Photocatalysts

Angewandte Chemie, Volume 137, Issue 36, September 1, 2025.
Privileged chiral catalysts have transformed asymmetric synthesis, conferring generality to processes that are routinely leveraged in the construction of societally important functional small molecules. This mini‐review is intended to survey the conception and evolution of privileged chiral photocatalyst scaffolds that enable simultaneous orchestration
Emanuel Studer, Smita Mandal, Timo Stünkel, Ryan Gilmour   +3 more
wiley   +2 more sources