Results 91 to 100 of about 10,045 (252)

Switching Enantioselectivity in Phenylalanine Ammonia Lyase for the Synthesis of Electron‐Deficient Aromatic d‐Amino Acids

Angewandte Chemie, Volume 137, Issue 43, October 20, 2025.
Phenylalanine ammonia lyases (PALs) were engineered to switch enantioselectivity, enabling hydroamination for the direct synthesis of electron‐deficient aromatic d‐amino acids (d‐AA). Structure‐guided engineering provided PAL variants with broad substrate scope, high activity, and excellent d‐selectivity, broadening the utility of PALs in asymmetric ...
Ivan Buslov, Sarah Desmons, Weijin Wang, Laura Elena Massaad, Xile Hu   +4 more
wiley   +1 more source

Utility of N-2-pyridyl-3-oxobutanamide in heterocyclic synthesis: Synthesis of new dihydropyridine, fused pyridine, pyridopyridine, pyridazine and pyridopyrimidinethione derivatives [PDF]

, 2010
2-Aminopyridine was fused with ethyl acetoacetate without solvent for two hours to yield the  N-2-pyridyl–3-oxobutanamide 1. However, when the reaction time was increased to 5 hours a structure 3 was obtained.
Abdel Hafiz, I., Baker, Safaa, Hussein, A.   +2 more
core  

Synthesis and characterization of some heterocyclic including oxazoles,Thiazoles, Pyridazines, phthalizines and Pyrazoles with evaluating of biological activity.

مجلة بغداد للعلوم, 2013
A series of new compounds including p-bromo methyl pheno acetate [2]. N-( aminocarbonyl)–p-bromo pheno acetamide [3] , N-( aminothioyl) -p-bromo phenoacetyl amide [4], N-[4-(p-di phenyl)-1,3-oxazol-2-yl]-p-bromopheno acetamide [5],N-[4-p-di phenyl]-1,3 ...
Baghdad Science Journal
doaj   +1 more source

Synthesis and Characterization of Unique Pyridazines [PDF]

, 2022
The field of semiconductive organic chemistry is vast and expanding as numerous applications are being discovered for semiconductors. The research reported in this thesis focuses on the synthesis and characterization of three pyridazines. Pyridazines are
Hobbs, William
core   +1 more source

Novel 1,4-benzoxazine and 1,4-benzodioxine inhibitors of angiogenesis. [PDF]

, 2012
Esters of 1,4-benzoxazine and 1,4-benzodioxine compounds 1 and 10, which combine thrombin inhibitory and GPIIb/IIIa antagonistic activity in one molecule are shown to inhibit endothelial cell migration and tube formation in vitro and angiogenesis in the ...
Andrej Boháč, Arnaoutova, Auerbach, Carmeliet, Caunt, Crawford, Cristofanilli, Danijel Kikelj, Ebos, Ferrara, Ferro, Folkman, Ilaš, Ilić, Ilić, Janez Ilaš, Khachigian, Liekens, Miloš Ilić, Nierodzik, Nierodzik, Pennacchietti, Petra Dunkel, Prins, Pàez-Ribes, Péter Mátyus, Rhee, Sabrkhany, Samant, Sandra Liekens, Sleeman, Sorensen, Staton, Steeg, Tsopanoglou, Tsopanoglou, Štefanič Anderluh   +36 more
core   +1 more source

Decision letter for "Steric and Electronic Effects on the 1 H Hyperpolarisation of Substituted Pyridazines by Signal Amplification by Reversible Exchange"

, 2021

openalex   +1 more source

Development of novel antibiotics derived from pyridazine: Synthesis, spectroscopic characterization, in vitro antimicrobial activity and molecular docking studies

Results in Chemistry
In light of the increasing antibiotic resistance, it is crucial to discover new antimicrobial medications. Pyridazines are frequently investigated in research for the development of new chemical entities with enhanced therapeutic properties.
Mouad Lahyaoui, Mouad Filali, Khadija Benamar, Riham Sghyar, Kawtar Fikri-Benbrahim, Amal Haoudi, Ahmed Mazzah, Souad El khattabi, El Mestafa El Hadrami, Youssef Kandri Rodi, Nada Kheira Sebbar   +10 more
doaj   +1 more source

Synthesis and cytotoxic activity of some novel benzocoumarin derivatives under solvent free conditions

Green Chemistry Letters and Reviews, 2019
In the present study, a rapid, less expensive, clean and environmental friendly route to synthesis new pyrazoles, pyrazolopyridazines and condensed pyrimidines was developed via grinding of 2-(3-(dimethylamino)acryloyl)-3H-benzo[f]chromen-3-one (1) with ...
Anhar Abdel-Aziem, Huda Refaat Mahmoud Rashdan, Entesar Mohamed Ahmed, Sara N. Shabaan   +3 more
doaj   +1 more source

Synthesis and antibacterial activity of 2-phenyl-5-aryl-4, 5, 6, 7, 8, 9-hexahydro-1,2.4-triazolo[1,5-A]quinazolines [PDF]

, 2013
A method for the synthesis of 2-phenyl-5-aryl-4, 5, 6, 7, 8,9- hexahydrotriazolo[1,5-a] quinazolines was developed.3-Amino-5-phenyl-1,2,4-triazole formed Schiff’s bases with aromatic aldehydes which on treatment with cyclohexanonein the presence of ...
Ain Khan, Misbahul, Ali Munawar, Munawar, Aslam, Samina, Nazeer, Areesha, Parveen, Najma   +4 more
core  

Antidiabetic Activity of an Alkaloid (4a-Methyl-5-(6-Methylhept- 5-En-1-Yl)Octahydro-1H-Cyclopenta[A]Pyridazine) Isolated From Lumnitzera racemosa in Streptozotocin-Induced Diabetic Wistar Rats

, 2022
Ranjana Ranjana, Deepak Kumar Singh, B. L. Jadhav   +2 more
openalex   +2 more sources