Results 11 to 20 of about 10,186 (207)

A One-Pot Approach to Novel Pyridazine C-Nucleosides

Molecules, 2021
The synthesis of glycosides and modified nucleosides represents a wide research field in organic chemistry. The classical methodology is based on coupling reactions between a glycosyl donor and an acceptor.
Flavio Cermola, Serena Vella, Marina DellaGreca, Angela Tuzi, Maria Rosaria Iesce   +4 more
doaj   +1 more source

Boron Trifluoride-Mediated Cycloaddition of 3-Bromotetrazine and Silyl Enol Ethers: Synthesis of 3-Bromo-pyridazines.

Journal of Organic Chemistry, 2021
Pyridazines are important scaffolds for medicinal chemistry or crop protection agents, yet the selective preparation of 3-bromo-pyridazines with high regiocontrol remains difficult.
Simon D Schnell, Jorge A. González, Jan Sklyaruk, A. Linden, K. Gademann   +4 more
semanticscholar   +1 more source

Synthesis and X-ray Crystal Structure Analysis of Substituted 1,2,4-Triazolo [4’,3’:2,3]pyridazino[4,5-b]indole and Its Precursor

Crystals, 2023
The hit compound 1,2,4-triazolo[4’,3’:2,3]pyridazino[4,5-b]indole 3 was synthesized from the reflux of 4-amino-5-indolyl-1,2,4-triazole-3-thione 1 with 4′-bromoacetophenone 2 in methanol catalyzed by concentrated HCl and the desired final molecule was ...
Ahmed T. A. Boraei, Elsayed H. Eltamany, Matti Haukka, Saied M. Soliman, Assem Barakat, Manar Sopaih   +5 more
doaj   +1 more source

5,6-Dihydro-[1,2,5]oxadiazolo[3,4-d]pyridazine-4,7-dione

Molbank, 2023
1,2,5-Chalcogenadiazoles fused with electron-withdrawing heterocycles have been actively investigated for the preparation of organic photovoltaic materials. [1,2,5]Oxadiazolo[3,4-d]pyridazines are much less studied than other chalcogenadiazolopyridazines
Timofey N. Chmovzh, Karim S. Gaisin, Oleg A. Rakitin   +2 more
doaj   +1 more source

Hydrazides in the reaction with hydroxypyrrolines: less nucleophilicity – more diversity

Beilstein Journal of Organic Chemistry, 2021
Expedient protocols for the synthesis of three types of highly functionalized azaheterocyclic scaffolds (dihydropyridazines, tetrahydropyridazines, and partially saturated tricyclic systems) from readily available hydroxypyrrolines and hydrazides are ...
Dmitrii A. Shabalin, Evgeniya E. Ivanova, Igor A. Ushakov, Elena Yu. Schmidt, Boris A. Trofimov   +4 more
doaj   +1 more source

Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids

Chemistry Proceedings, 2023
Heterocyclic derivatives of hormones have attracted great interest as a privileged scaffold for drug discovery due to their outstanding biological activity.
Yulia Volkova, Alexander Scherbakov, Igor Zavarzin   +2 more
doaj   +1 more source

A Multifield Study on Dimethyl Acetylenedicarboxylate: A Reagent Able to Build a New Cycle on Diaminoimidazoles

Molecules, 2022
A new effective method for the synthesis of imidazo[1,5-b]pyridazines derivatives (yields = 68–89%) by the interaction of 1,2-diamino-4-phenylimidazole with DMAD, in methanol and in the presence of a catalytic amount of acetic acid, is proposed.
Dmitrii Yu. Vandyshev, Oleg N. Burov, Anton V. Lisovin, Daria A. Mangusheva, Mikhail A. Potapov, Tatiana N. Ilyinova, Khidmet S. Shikhaliev, Athina Geronikaki, Domenico Spinelli   +8 more
doaj   +1 more source

Pyridazines. IX. Proton Magnetic Resonance Studies of Pyridazine, Pyrazine, and Substituted Pyridazines.

Chemical and Pharmaceutical Bulletin, 1964
Pyridazine, pyrazine and substituted pyridazines have been studied by proton magnetic resonance spectroscopy. The spectra of pyridazine and pyrazine were analyzed completely with the aid of information obtained from the C13-satellites (in natural isotopic abundance), whereas the spectra of substituted pyridazines were analyzed easily by the usual ...
K, Tori, M, Ogata
openaire   +3 more sources

Asymmetric Cu-Catalyzed 1,4-Dearomatization of Pyridines and Pyridazines without Preactivation of the Heterocycle or Nucleophile.

Journal of the American Chemical Society, 2018
We show that a chiral copper hydride (CuH) complex catalyzes C-C bond-forming dearomatization of pyridines and pyridazines at room temperature. The catalytic reaction operates directly on free heterocycles and generates the nucleophiles in situ ...
Michael W. Gribble, Sheng-Mei Guo, S. Buchwald   +2 more
semanticscholar   +1 more source

Multi Component Reactions under Increased Pressure: On the Mechanism of Formation of Pyridazino[5,4,3-de][1,6]naphthyridine Derivatives by the Reaction of Malononitrile, Aldehydes and 2-Oxoglyoxalarylhydrazones in Q-Tubes

Molecules, 2017
Efficient synthesis of phenanthridin-6(5H)-one derivatives 12a–n in a four-component reaction of aldehyde hydrazone, aromatic aldehydes and malononitrile in Q-Tubes is reported. The results showed that the methodology has the advantage of being a one-pot
Majdah A. AL-Johani, Khadijah M. Al-Zaydi, Sameera M. Mousally, Norah F. Alqahtani, Noha Hilmy Elnagdi, Mohamed H. Elnagdi   +5 more
doaj   +1 more source