Results 11 to 20 of about 10,045 (252)
Deuteration of Six-Membered N-Heteroarenes: Chemistry and Applications. [PDF]
ChemistryDeuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Raju L +4 more
europepmc +2 more sources
Crystals, 2023 The hit compound 1,2,4-triazolo[4’,3’:2,3]pyridazino[4,5-b]indole 3 was synthesized from the reflux of 4-amino-5-indolyl-1,2,4-triazole-3-thione 1 with 4′-bromoacetophenone 2 in methanol catalyzed by concentrated HCl and the desired final molecule was ...
Ahmed T. A. Boraei +5 more
doaj +1 more source
5,6-Dihydro-[1,2,5]oxadiazolo[3,4-d]pyridazine-4,7-dione
Molbank, 2023 1,2,5-Chalcogenadiazoles fused with electron-withdrawing heterocycles have been actively investigated for the preparation of organic photovoltaic materials. [1,2,5]Oxadiazolo[3,4-d]pyridazines are much less studied than other chalcogenadiazolopyridazines
Timofey N. Chmovzh +2 more
doaj +1 more source
Hydrazides in the reaction with hydroxypyrrolines: less nucleophilicity – more diversity
Beilstein Journal of Organic Chemistry, 2021 Expedient protocols for the synthesis of three types of highly functionalized azaheterocyclic scaffolds (dihydropyridazines, tetrahydropyridazines, and partially saturated tricyclic systems) from readily available hydroxypyrrolines and hydrazides are ...
Dmitrii A. Shabalin +4 more
doaj +1 more source
Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
Chemistry Proceedings, 2023 Heterocyclic derivatives of hormones have attracted great interest as a privileged scaffold for drug discovery due to their outstanding biological activity.
Yulia Volkova +2 more
doaj +1 more source
Molecules, 2022 A new effective method for the synthesis of imidazo[1,5-b]pyridazines derivatives (yields = 68–89%) by the interaction of 1,2-diamino-4-phenylimidazole with DMAD, in methanol and in the presence of a catalytic amount of acetic acid, is proposed.
Dmitrii Yu. Vandyshev +8 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Human health in the current medical era is facing numerous challenges, especially cancer. So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small molecules that selectively target tumour cells with minimal toxicity ...
Ahmed Sabt +6 more
doaj +1 more source
Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters. [PDF]
Angew Chem Int Ed EnglThe intracellular delivery of trans‐cyclooctene and bicyclo[6.1.0]nonyne as sterically demanding groups for the inverse electron‐demand Diels–Alder was achieved by the triphosphate prodrug (TriPPPro) strategy. Once hydrolyzed inside cells, the modified uridines and cytidines are metabolically incorporated into nascent RNA, are labelled by a dual ...
Knaack JIH +6 more
europepmc +2 more sources
Chemical and Pharmaceutical Bulletin, 1964 Pyridazine, pyrazine and substituted pyridazines have been studied by proton magnetic resonance spectroscopy. The spectra of pyridazine and pyrazine were analyzed completely with the aid of information obtained from the C13-satellites (in natural isotopic abundance), whereas the spectra of substituted pyridazines were analyzed easily by the usual ...
K, Tori, M, Ogata
openaire +3 more sources
The Cu(OTf)2 catalysed microwave assisted synthesis of a new scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one [PDF]
, 2014 The synthesis of novel 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is described including a one-step Mannich-type reaction followed by intramolecular ring closure of ethyl 3-methylpyridazine-4- carboxylate and aldimines, catalysed by the Lewis ...
De Coen, Laurens +5 more
core +2 more sources