Results 41 to 50 of about 4,025 (222)

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Diazo Transfer From Nitrous Oxide Employing Phosphorus Ylides

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
A phosphorus ylide‐mediated strategy achieves the direct fixation of nitrous oxide (N2O) to access diazo compounds, which after intra‐ or intermolecular trapping, afford N2‐containing organic building blocks. This approach provides an alternative to hazardous diazo‐transfer reagents and establishes N2O fixation as a sustainable methodology.
Jhen‐Kuei Yu, Jan Niclas Ludwig, Patrick Wolf Antoni, David Tymann, Max Martin Hansmann   +4 more
wiley   +2 more sources

Synthesis and quantitative structure–activity relationship study of substituted imidazophosphor ester based tetrazolo[1,5-b]pyridazines as antinociceptive/anti-inflammatory agents

Beilstein Journal of Organic Chemistry, 2013
A high-yielding general synthesis of imidazophosphor ester based tetrazolo[1,5-b]pyridazines is described. A conjugated reaction between 3,6-diazidopyridazine and different types of phosphonyl carbanion reagents followed by intramolecular cyclization ...
Wafaa M. Abdou, Neven A. Ganoub, Eman Sabry   +2 more
doaj   +1 more source

Synthesis of pyridazines via furan vinamidinium salts

, 1988
Reaction of 5-(N,N-dimethylamino)-2-furfurylidene-N,N-dimethyliminium bromide (I) with hydrazine affords 3-hydrazono-2,3,4,5-tetrahydro-6-methylenehydrazonopyridazine (III). 5-(N,N-Dialkylamino)-2-arylazofuran salts II react with the same reagent to give
Jaroslav Kováč, Zdeněk Arnold, Tibor Gracza   +2 more
core   +1 more source

Pyridine-to-Pyridazine Skeletal Editing

Journal of the American Chemical Society
Nitrogen-containing heterocycles underpin many pharmaceuticals, where subtle atomic rearrangements can markedly alter efficacy and safety. Pyridines are ubiquitous scaffolds in pharmaceuticals, yet their close analogues, pyridazines with two adjacent ring nitrogens, remain underexplored owing to limited synthetic access.
Wonjun Choi, Ahyoung Jang, Sungwoo Hong
openaire   +2 more sources

Design Rules for Controlling Connectivity, Topology, and Sorting Using Hydrogen‐Bonded Pairs and Aromatic Components in Palladium(II)‐Based Interlocked and Foldameric Systems

Angewandte Chemie, Volume 138, Issue 22, 25 May 2026.
We have established a set of design rules which combine Pd(II) metal coordination, complementary geometries, complementary interligand hydrogen bonding and π─π interactions for predictable self‐assembly of Pd(II)‐based species such as metallo‐foldamers, cyclic species a metallo‐interlocked clippane. The species persist in a combinatorial mixture due to
Jess L. Algar, Jordan N. Smith, Dan Preston   +2 more
wiley   +2 more sources

The Study of Pyridazine Compounds on Prostanoids: Inhibitors of COX, cAMP Phosphodiesterase, and TXA2 Synthase

Journal of Chemistry, 2014
The pyridazine moiety is an important structural feature of various pharmacological active compounds. Synthetic pyridazine compounds have been reported as effective antiprostaglandins (PGs), 5-lipoxygenase (5-LOX), and antiplatelet agents, that is ...
Mohammad Asif
doaj   +1 more source

Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and in silico studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A novel series of pyrazole analogues including hydrazones, pyrazolo[4,3-c]-pyridazines, pyrazolo[3,4-e][1,2,4]triazine and pyrazolo[3,4-d][1,2,3]triazoles was designed, synthesised and screened for their in vitro antimicrobial and DHFR inhibition ...
Ismail M. M. Othman, Mohamed A. M. Gad-Elkareem, Abd El-Galil E. Amr, Mohamed A. Al-Omar, Eman S. Nossier, Elsayed A. Elsayed   +5 more
doaj   +1 more source

4,7-Di(9H-carbazol-9-yl)-[1,2,5]oxadiazolo[3,4-d]pyridazine

Molbank, 2022
Donor–acceptor–donor (D–A–D)-type molecules are considered as a promising class of NIR fluorescence materials. In this communication, 4,7-di(9H-carbazol-9-yl)-[1,2,5]oxadiazolo[3,4-d]pyridazine was obtained by dehydrogenation of 4,7-bis(1,2,3,4,4a,9a ...
Timofey N. Chmovzh, Timofey A. Kudryashev, Karim S. Gaisin, Oleg A. Rakitin   +3 more
doaj   +1 more source

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, EarlyView.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source