Results 31 to 40 of about 2,941 (178)

Polyfunctional Nitriles in Organic Syntheses: A Novel Route to Aminopyrroles, Pyridazines and Pyrazolo[3,4-c]pyridazines

Molecules, 2009
Phenacylmalononitrile 1 reacts with dimethylformamide dimethyl acetal to yield an enaminone which could be readily converted into a pyrrole or an aminopyridazine by treating with ammonium acetate and hydrazine hydrate, respectively.
Mohamed Hilmy Elnagdi, Heinz Kolshorn, Herbert Meier, Saleh M. Al-Mousawi, Moustafa Sherief Moustafa   +4 more
doaj   +1 more source

Synthesis, Anticancer Activities and Molecular Docking Studies of a Novel Class of 2-Phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazine Derivatives Bearing Sulfonamides

Molecules, 2022
In the present study, new 2-phenyl-5,6,7,8-tetrahydroimidazo [1,2-b]pyridazines bearing sulfonamides were synthesized, characterized and evaluated for their anticancer activities.
Otmane Bourzikat, Abdelmoula El Abbouchi, Hamza Ghammaz, Nabil El Brahmi, Elmostfa El Fahime, Arnaud Paris, Richard Daniellou, Franck Suzenet, Gérald Guillaumet, Saïd El Kazzouli   +9 more
doaj   +1 more source

Electrolyte Additive Strategies in Aqueous Zn‐Ion Batteries: Recent Advances and Prospects

Advanced Science, EarlyView.
This article provides a comprehensive overview of the current status and future development directions of AZIBs electrolyte additives in three aspects: stabilizing zinc anodes (uniform deposition, inhibition of dendritic crystals), protecting cathodes (structural stability, inhibition of dissolution), and enhancing electrolyte stability (wider ...
Yuanze Yu, Hongmin Liu, Long Fan, Huakun Liu, Shixue Dou, Guoxiu Wang, Nana Wang, Zhongchao Bai   +7 more
wiley   +1 more source

Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains

Beilstein Journal of Organic Chemistry, 2017
Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines.
Layal Hariss, Kamal Bou Hadir, Mirvat El-Masri, Thierry Roisnel, René Grée, Ali Hachem   +5 more
doaj   +1 more source

4,7-Dichloro[1,2,5]oxadiazolo[3,4-d]pyridazine 1-oxide

Molbank, 2018
Dihalogenated derivatives of [1,2,5]chalcogenadiazolo[3,4-d]pyridazines are of interest as precursors for both photovoltaic materials and biologically active compounds.
Timofey Chmovzh, Ekaterina Knyazeva, Vadim Popov, Oleg Rakitin   +3 more
doaj   +1 more source

Synthesis and quantitative structure–activity relationship study of substituted imidazophosphor ester based tetrazolo[1,5-b]pyridazines as antinociceptive/anti-inflammatory agents

Beilstein Journal of Organic Chemistry, 2013
A high-yielding general synthesis of imidazophosphor ester based tetrazolo[1,5-b]pyridazines is described. A conjugated reaction between 3,6-diazidopyridazine and different types of phosphonyl carbanion reagents followed by intramolecular cyclization ...
Wafaa M. Abdou, Neven A. Ganoub, Eman Sabry   +2 more
doaj   +1 more source

1,2,3-Triazole-4(5)-amines – Convenient Synthetic Blocks for the Construction of Triazolo-Annulated Heterocycles

Журнал органічної та фармацевтичної хімії, 2022
Aim. To analyze and summarize the synthetic potential of 1,2,3-triazole-4(5)-amines as efficient building blocks in the synthesis of triazolo-annulated pyridine, azine and azepine systems. Results and discussion.
Natalia O. Syrota, Sergiy V. Kemskiy, Lesya M. Saliyeva, Mykhailo V. Vovk   +3 more
doaj   +1 more source

Photoinduced H-Bonding EDA complex-enabled skeletal editing of furans to pyridazines

Nature Communications
Skeletal editing enables direct structural reorganization of molecular frameworks, providing a powerful strategy for rapid exploration of chemical space in lead optimization.
Juan Tang, Pingyao Gan, Wenjing Li, Lin Peng, Guiyu Yang, Yuying He, Shikun Zhou, Ting Long, Chong Tian, Haiyan Fu, Shun Li   +10 more
doaj   +1 more source

Nitrogen‐Site Isomerism Unlocks Exciton Dissociation in Vinylene‐Linked COF‐Based Photocatalysts

EcoEnergy, EarlyView.
Two regioisomeric vinylene‐linked covalent organic frameworks (COFs) constructed from diazine units with different nitrogen positions are developed for photocatalytic hydrogen evolution reaction (HER). Although structurally similar, the isomeric COFs exhibit distinct electron distribution and charge‐separation behaviors, leading to a more than twofold ...
Ming Wang, Zhongliang Wen, Chengbo Zhang, Wei Wang, Yaling Li, Xiaofang Su, Rached Ousji, Yanqiong Luo, Muhammad Imran Anwar, Rengui Li, Yanan Gao   +10 more
wiley   +1 more source

Novel heterocyclic hybrids of pyrazole targeting dihydrofolate reductase: design, biological evaluation and in silico studies

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
A novel series of pyrazole analogues including hydrazones, pyrazolo[4,3-c]-pyridazines, pyrazolo[3,4-e][1,2,4]triazine and pyrazolo[3,4-d][1,2,3]triazoles was designed, synthesised and screened for their in vitro antimicrobial and DHFR inhibition ...
Ismail M. M. Othman, Mohamed A. M. Gad-Elkareem, Abd El-Galil E. Amr, Mohamed A. Al-Omar, Eman S. Nossier, Elsayed A. Elsayed   +5 more
doaj   +1 more source