Results 11 to 20 of about 4,025 (222)
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Human health in the current medical era is facing numerous challenges, especially cancer. So, the therapeutic arsenal for cancer should be unremittingly enriched with novel small molecules that selectively target tumour cells with minimal toxicity ...
Ahmed Sabt +6 more
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Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines
Molecules, 2022 Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. Two typical modes of constructing these heterocyclic ring systems are cyclizing a heterocyclic diamine with a nitrite or ...
Gavin R. Hoffman, Allen M. Schoffstall
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Boron Trifluoride-Mediated Cycloaddition of 3-Bromotetrazine and Silyl Enol Ethers: Synthesis of 3-Bromo-pyridazines [PDF]
, 2021 Pyridazines are important scaffolds for medicinal chemistry or crop protection agents, yet the selective preparation of 3-bromo-pyridazines with high regiocontrol remains difficult.
González, Jorge A +4 more
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Crystals, 2023 The hit compound 1,2,4-triazolo[4’,3’:2,3]pyridazino[4,5-b]indole 3 was synthesized from the reflux of 4-amino-5-indolyl-1,2,4-triazole-3-thione 1 with 4′-bromoacetophenone 2 in methanol catalyzed by concentrated HCl and the desired final molecule was ...
Ahmed T. A. Boraei +5 more
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5,6-Dihydro-[1,2,5]oxadiazolo[3,4-d]pyridazine-4,7-dione
Molbank, 2023 1,2,5-Chalcogenadiazoles fused with electron-withdrawing heterocycles have been actively investigated for the preparation of organic photovoltaic materials. [1,2,5]Oxadiazolo[3,4-d]pyridazines are much less studied than other chalcogenadiazolopyridazines
Timofey N. Chmovzh +2 more
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Hydrazides in the reaction with hydroxypyrrolines: less nucleophilicity – more diversity
Beilstein Journal of Organic Chemistry, 2021 Expedient protocols for the synthesis of three types of highly functionalized azaheterocyclic scaffolds (dihydropyridazines, tetrahydropyridazines, and partially saturated tricyclic systems) from readily available hydroxypyrrolines and hydrazides are ...
Dmitrii A. Shabalin +4 more
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Thiohydrazides in the Synthesis of Functionalized Extranuclear Heterosteroids
Chemistry Proceedings, 2023 Heterocyclic derivatives of hormones have attracted great interest as a privileged scaffold for drug discovery due to their outstanding biological activity.
Yulia Volkova +2 more
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PIM KINASES INHIBITORS AND PYRIMIDINE-BASED ANTICANCER AGENTS [PDF]
Al-Azhar Journal of Pharmaceutical Sciences, 2023 Human phosphatidyl inositol mannoside kinases (Pim kinases) are important biological target for discovery of new anticancer agents. In addition, Pyrimidines have a good contribution as building blocks of many anticancer agents. Hence, a literature survey
ibrahim issa +3 more
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Molecules, 2022 A new effective method for the synthesis of imidazo[1,5-b]pyridazines derivatives (yields = 68–89%) by the interaction of 1,2-diamino-4-phenylimidazole with DMAD, in methanol and in the presence of a catalytic amount of acetic acid, is proposed.
Dmitrii Yu. Vandyshev +8 more
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Chemical and Pharmaceutical Bulletin, 1964 Pyridazine, pyrazine and substituted pyridazines have been studied by proton magnetic resonance spectroscopy. The spectra of pyridazine and pyrazine were analyzed completely with the aid of information obtained from the C13-satellites (in natural isotopic abundance), whereas the spectra of substituted pyridazines were analyzed easily by the usual ...
Tori, Kazuo, Ogata, Masaru
openaire +3 more sources