Results 51 to 60 of about 2,941 (178)

Pyridine-to-Pyridazine Skeletal Editing

Journal of the American Chemical Society
Nitrogen-containing heterocycles underpin many pharmaceuticals, where subtle atomic rearrangements can markedly alter efficacy and safety. Pyridines are ubiquitous scaffolds in pharmaceuticals, yet their close analogues, pyridazines with two adjacent ring nitrogens, remain underexplored owing to limited synthetic access.
Wonjun Choi, Ahyoung Jang, Sungwoo Hong
openaire   +2 more sources

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, Volume 65, Issue 31, 27 July 2026.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Versatile Palladium‐Catalyzed C‐H Arylation of Fluoroarenes with 2‐Chloropyridine Derivatives

Chemistry – A European Journal, Volume 32, Issue 28, 25 July 2026.
Direct C─H arylation of fluoroarenes with 2‐chloropyridines is enabled by a simple Pd/SPhos system in isopropyl acetate. The method uses inexpensive reactants and shows broad scope and high yields. DFT computations explain reactivity and selectivity.
Federico Belnome, Péter P. Fehér, András Stirling, Csongor G. Németh, Tamás Hergert, György M. Keserű, Péter Ábrányi‐Balogh   +6 more
wiley   +1 more source

Comparative Study of new Pyridazine Derivatives Towards Corrosion of Copper in Nitric Acid: Part-1

International Journal of Electrochemical Science, 2010
The inhibition of the corrosion of copper in 2M HNO3 by 5-[hydroxy(phenyl)methyl]-6-methylpyridazin-3(2H)-one (P1), 4-(2-chlorobenzyl)-6-hydrazino-3-methyl-1,6-dihydropyridazine (P2), 5-(2,6-dichlorobenzyl)-6-methylpyridazin-3(2H)-one (P3) and 5-[(2 ...
A. Zarrouk, T. Chelfi, A. Dafali, B. Hammouti, S.S. Al-Deyab, I. Warad, N. Benchat, M. Zertoubi   +7 more
doaj   +1 more source

Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for effective vascular endothelial growth 2 (VEGFR-2) inhibition ...
Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, Sohair M. Khojah, Marawan Ahmed, Khaled Barakat, Khaled A. M. Abouzid   +6 more
doaj   +1 more source

Synthesis and characterization of some heterocyclic including oxazoles,Thiazoles, Pyridazines, phthalizines and Pyrazoles with evaluating of biological activity.

مجلة بغداد للعلوم, 2013
A series of new compounds including p-bromo methyl pheno acetate [2]. N-( aminocarbonyl)–p-bromo pheno acetamide [3] , N-( aminothioyl) -p-bromo phenoacetyl amide [4], N-[4-(p-di phenyl)-1,3-oxazol-2-yl]-p-bromopheno acetamide [5],N-[4-p-di phenyl]-1,3 ...
Baghdad Science Journal
doaj   +1 more source

Synthesis, characterization and evaluation of the antioxidant and antibacterial activities of new polycyclic fused pyrimido-pyridazines and pyridazino-purines [PDF]

Brazilian Journal of Pharmaceutical Sciences
A series of fused pyrimido[4,5-d]pyridazin-2(1H)-one, pyrimido[3’,4’:3,2]pyrimido[5,4-d]pyridazin-10-one, pyridazino[4’,5’:5,6]pyrimido[2,1-i]purine and pyridazino[4’,5’:4,5]pyrimido[2,3-b]purin-4(5H)-one were designed and prepared by condensation of ...
Ichrak Bouguessa, Mohamed Dehamchia, Nawal Khier, Samir Bayou, Abdelhafeez M. A. Mohammed, Abdelkrim Gouasmia, Zine Regaïnia   +6 more
doaj   +2 more sources

Development of novel antibiotics derived from pyridazine: Synthesis, spectroscopic characterization, in vitro antimicrobial activity and molecular docking studies

Results in Chemistry
In light of the increasing antibiotic resistance, it is crucial to discover new antimicrobial medications. Pyridazines are frequently investigated in research for the development of new chemical entities with enhanced therapeutic properties.
Mouad Lahyaoui, Mouad Filali, Khadija Benamar, Riham Sghyar, Kawtar Fikri-Benbrahim, Amal Haoudi, Ahmed Mazzah, Souad El khattabi, El Mestafa El Hadrami, Youssef Kandri Rodi, Nada Kheira Sebbar   +10 more
doaj   +1 more source

Synthesis and cytotoxic activity of some novel benzocoumarin derivatives under solvent free conditions

Green Chemistry Letters and Reviews, 2019
In the present study, a rapid, less expensive, clean and environmental friendly route to synthesis new pyrazoles, pyrazolopyridazines and condensed pyrimidines was developed via grinding of 2-(3-(dimethylamino)acryloyl)-3H-benzo[f]chromen-3-one (1) with ...
Anhar Abdel-Aziem, Huda Refaat Mahmoud Rashdan, Entesar Mohamed Ahmed, Sara N. Shabaan   +3 more
doaj   +1 more source

New Horizon and Advancements in Synthetic and Biological Applications of Active Methylene Acetonitrile: Mini-Review

Journal of Chemistry
Acetonitrile is generally used as an organic solvent and can also be used as a significant starting material via active methylene acetonitrile in organic synthesis.
Lavanya Nagamalla, Kavitha Kothireddy, Basavarajaiah Suliphuldevara Mathada, Sharanagouda J. Patil, Lavanya Lakshminarayana   +4 more
doaj   +1 more source