Results 51 to 60 of about 4,025 (222)

A Novel and Convenient Protocol for Synthesis of Pyridazines

, 2016
A new flexible strategy for the synthesis of diversely functionalized pyridazines from 4-chloro-1,2-diaza-1,3-butadienes and active methylene compounds is reported. The high chemoselectivity of this approach offers access to structural precursors of GABA-
Paolino Filippone (2032666), Stefania Santeusanio (1918225), Francesca R. Perrulli (2320960), Gianfranco Favi (1617454), Orazio A. Attanasi (1617448)   +4 more
core   +1 more source

π-Bond Screening in Benzonorbornadienes: The Role of 7-Substituents in Governing the Facial Selectivity for the Diels-Alder Reaction of Benzonorbornadienes with 3,6-Di(2-pyridyl)-s-Tetrazine

Molecules, 2001
Benzonorbornadiene 21, 7-spirocyclopropylbenzonorbornadiene 23, 7,7-dimethylbenzonorbornadiene 25, and 7-spirocyclopentylbenzonorbornadiene 27 have been reacted with 3,6-di(2-pyridyl)-s-tetrazine (rate: 21>23>25=27) to form symmetrical 4,5 ...
Peter A. Harrison, Ronald N. Warrener
doaj   +1 more source

Photochemistry of Aromatic N‐Oxides in Water Probed by Time‐Resolved X‐ray Absorption Spectroscopy

Chemistry – A European Journal, EarlyView.
Time‐resolved XAS at the nitrogen and oxygen K‐edges is applied to the photorearrangement of two N‐oxides in water. Pyridine N‐oxide rapidly forms the oxaziridine isomer. Pyridazine N‐oxide undergoes ring opening to the diazo compound, without any evidence of intermediates.
Maximilian Paradiz Domínguez, Robby Büchner, Mattis Fondell, Albert M. Brouwer   +3 more
wiley   +1 more source

Synthesis of Indeno [1,2-c] Pyridazines as Possible Antifungal Agents

, 1981
Department of Applied Chemistry, Calcutta University, 92, Acharya Prafulla Chandra Road, Calcutta-700 009 Manuscript received 10 January 1979, revised 20 May 1981, accepted 11 August 1981 Synthesis of Indeno [1,2-c] Pyridazines as Possible Antifungal ...
P. MUKHERJEE, B. PATHAK
core   +1 more source

Glycerol and Q-Tubes: Green Catalyst and Technique for Synthesis of Polyfunctionally Substituted Heteroaromatics and Anilines

Molecules, 2019
The role of glycerol as a green bio-based solvent, reactant, and/or a catalyst in the synthesis of novel heterocycles, under pressure, is studied. Synthesis of novel quinolines in good yields using a new modified Skraup synthesis, utilizing glycerol and ...
Douaa Salman AlMarzouq, Noha M. Hilmy Elnagdi   +1 more
doaj   +1 more source

Mild N‑Arylation of Sulfoximines With (Hetero)aryl Chlorides Enabled by α‐Methylnaphthyl‐tBuBrettPhos Palladium Triflate

Chemistry – A European Journal, EarlyView.
A readily accessible, air‐ and moisture‐stable palladium precatalyst, [Pd(1‐MeNAP)(tBuBrettPhos)]OTf, enables the direct N‐arylation of NH‐sulfoximines with (hetero)aryl chlorides under exceptionally mild conditions ideal for late‐stage diversification of drug‐like scaffolds.
Sourav Manna, Mahima Pilania, Kumarjit Sen, Nikolaos V. Tzouras, Angelino Doppiu, Lukas J. Gooßen   +5 more
wiley   +1 more source

Microwave-assisted synthesis of polysubstituted pyridazines

, 2005
3,4,6-Trisubstituted pyridazines are prepared through a microwave-assisted cyclocondensation of differently substituted 1,4-diketones and hydrazine in the presence of DDQ.
Lampariello, Lucia Raffaella, Maurizio Taddei, Taddei, Maurizio, L. Raffaella Lampariello, Minetto, Giacomo, Giacomo Minetto   +5 more
core   +1 more source

Monosubstituted N‐Arylhydroxylamine Chemistry: Integrating Contemporary Synthetic Approaches for the Efficient Construction of Diverse Heterocyclic Scaffolds

Chemistry – A European Journal, EarlyView.
Monosubstituted N‐arylhydroxylamines represent a unique subclass of hydroxylamines that act as pivotal intermediates in redox transformations and as versatile platforms for further synthetic transformations. They serve as key building blocks in the synthesis of architecturally complex heterocycles and other valuable organic compounds.
Michael G. Kallitsakis, Kyriakos D. Nikopoulos, Ioannis N. Lykakis   +2 more
wiley   +1 more source

Synthesis of substituted pyridines and pyridazines via ring closing metathesis.

, 2009
RCM can be used to make aromatic heterocycles, namely pyridines and, for the first time, pyridazines; the key step after RCM involves elimination of sulfinate to provide the aromatic ...
Thompson, Amber, Donohoe, Timothy J., Bower, JF, Basutto, Jose A., Donohoe, Timothy, Donohoe, TJ, Procopiou, Panayiotis A., Fishlock, Lisa P., Procopiou, PA, Thompson, AL, Fishlock, LP, Thompson, Amber L., Basutto, JA, Bower, John F.   +13 more
core   +1 more source

Mesityl‐Substituted Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxalines: Synthesis, Functionalization, Photophysical, and Electrochemical Properties

European Journal of Organic Chemistry, EarlyView.
Azuleno[1′,2′:4,5]pyrrolo[2,3‐b]quinoxaline with a mesityl group as a solubilizing group was synthesized. By synthesizing derivatives in which various functional groups were introduced into two electronically distinct sites, the pyrrole nitrogen atom and the azulene five‐membered ring, we were able to reveal that the photophysical and electrochemical ...
Ryuta Sekiguchi, Hiroki Mizuno, Ikumi Uchiyama, Souta Yuruka, Atsuya Shimizu, Taku Shoji, Shunji Ito   +6 more
wiley   +1 more source