Results 81 to 90 of about 10,045 (252)

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, Volume 25, Issue 12, December 2025.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

Reactions of pyridazines and pyridazine 1-oxides with nitrogen-containing nucleophiles [PDF]

In dit proefschrift is een orienterend onderzoek beschreven naar het chemisch gedrag van halogeen-pyridazinen en halogeen-pyridazine-N-oxiden met kaliumamide in vloeibare ammoniak, met methanolische ammoniak en met vloeibare ammoniak. Dit onderzoek hangt
Klinge, D.E.
core   +1 more source

Synthesis of some new 4,5-dihydro-6-(4-methoxy-3-methylphenyl)-3(2 H)-pyridazinone derivatives [PDF]

, 2010
The present study describes the synthesis of 4,5-dihydro-6-(4-methoxy-3-methylphenyl)-3(2H)-pyridazinone derivatives. The synthesis of the first target compound, 4,5-dihydro-6-(4-methoxy-3-methylphenyl)-3(2H)-pyridazinone(1), was achieved by Friedel ...
El-Sakka, Sahar, Soliman, Mohamed
core  

A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct [PDF]

, 2016
MASTL (microtubule-associated serine/threonine kinase-like), more commonly known as Greatwall (GWL), has been proposed as a novel cancer therapy target.
Alessi, Arumugam, Barr, Caldecott, Castro, Castro, Castro, Castro, Clarke, Cottens, Davies, Elkins, Glover, Goldberg, Goldberg, Goldberg, Goldberg, Gygi, Hochegger, Hunt, Johnson, Lorca, Malumbres, Malumbres, Malumbres, Mann, Mann, Mayer, Moreno, Neuwald, Ogiwara, Okuno, Peel, Peng, Piatti, Salemme, Steinberg, Sternberg, van Aalten, Wolthuis, Zhou   +40 more
core   +2 more sources

Transition Metal‐Free Ortho‐Deuteration of Electron‐Deficient N‐Heteroarenes

European Journal of Organic Chemistry, Volume 28, Issue 42, November 20, 2025.
Herin, the metal‐free, selective deuteration of electron‐deficient N‐heteroaromatics is reported using O‐carbamate and carboxamide ortho‐directing groups (DGs), lithium 2,2,6,6‐tetramethylpiperidide as the base, and D2O as a green source of D+. The substrate scope includes 10 small molecule N‐heteroaromatic compounds and two pharmaceutically relevant ...
Žiga Oražem, Luka Jedlovčnik, Jernej Birk, Andrej Pevec, Ross D. Jansen‐van Vuuren, Janez Košmrlj   +5 more
wiley   +1 more source

Cycloaddition reactions of conjugated azoalkenes [PDF]

, 2012
An overview of the use of 2H-azirines, conjugated nitrosoalkenes and conjugated azoalkenes bearing phosphorus substituents in addition and cycloaddition reactions is presented, focused on strategies for the synthesis of aminophosphonate and ...
Lemos, A.
core  

Coordination‐Driven Orthogonal Ligand Pairings through Dual Hydrogen‐Bonding/π‐π Interaction Complementarity

Chemistry – A European Journal, Volume 31, Issue 64, November 17, 2025.
A series of bidentate ligands for square‐planar Pd(II) complexes were developed, each with hydrogen‐bonding and π‐π‐stacking domains that are complementary to only one other ligand. The bis‐bidentate complexes form orthogonally to one another with high fidelity, but only when both interaction types are exploited in tandem.
Jordan N. Smith, Yolanda Yau, Nina R. Lawson, Rosemary J. Goodwin, Dan Preston   +4 more
wiley   +1 more source

Diazine Endo‐Functionalized Tetraphenylethylene‐Based Cyclo[6]arenes for Molecular Recognition in Both Solution and Aggregate States

Aggregate, Volume 6, Issue 11, November 2025.
To overcome poor molecular recognition in dilute solutions of tetraphenylethylene‐embedded cyclo[6]arenes, three macrocycles with functionalized cavities featuring diazine groups as endo‐binding sites are synthesized. Their recognition affinity continuously improves with increasing hydrogen‐bond acceptance of diazine groups.
Nan Pan, Shuhong Liu, Weichen Tan, Linbin Yao, Jialin Xie, Kelong Zhu, Chunman Jia   +6 more
wiley   +1 more source

Towards discovery of novel scaffold with potent antiangiogenic activity; design, synthesis of pyridazine based compounds, impact of hinge interaction, and accessibility of their bioactive conformation on VEGFR-2 activities

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
Pyridazine scaffolds are considered privileged structures pertaining to its novelty, chemical stability, and synthetic feasibility. In our quest towards the development of novel scaffolds for effective vascular endothelial growth 2 (VEGFR-2) inhibition ...
Maiy Y. Jaballah, Rabah A. T. Serya, Nasser Saad, Sohair M. Khojah, Marawan Ahmed, Khaled Barakat, Khaled A. M. Abouzid   +6 more
doaj   +1 more source

Metal Acetylides in Cycloaddition Reactions [PDF]

, 2017
This review highlights recent advances in the synthesis of (hetero)aromatic systems via cycloaddition reactions of alkynylmetals with dienes and dipoles.
Comas-Barceló, J., Harrity, J.P.A.
core   +1 more source