Results 21 to 30 of about 24,311 (267)

Synthesis of Chitosan-La₂O₃ Nanocomposite and Its Utility as a Powerful Catalyst in the Synthesis of Pyridines and Pyrazoles

Molecules, 2021
Recently, the development of nanocatalysts based on naturally occurring polysaccharides has received a lot of attention. Chitosan (CS), as a biodegradable and biocompatible polysaccharide, is considered to be an excellent template for the design of a ...
Khaled D. Khalil, Sayed M. Riyadh, Mariusz Jaremko, Thoraya A. Farghaly, Mohamed Hagar   +4 more
doaj   +1 more source

Intramolecular carbolithiation of N-allyl-ynamides: an efficient entry to 1,4-dihydropyridines and pyridines – application to a formal synthesis of sarizotan

Beilstein Journal of Organic Chemistry, 2012
We have developed a general synthesis of polysubstituted 1,4-dihydropyridines and pyridines based on a highly regioselective lithiation/6-endo-dig intramolecular carbolithiation from readily available N-allyl-ynamides.
Wafa Gati, Mohamed M. Rammah, Mohamed B. Rammah, Gwilherm Evano   +3 more
doaj   +1 more source

Effect of Atomic Charge and Some Physical Properties on pKa of Substituted Pyridines [PDF]

مجلة التربية والعلم, 1970
A number of different levels of theoretical calculations have been used for assigning the Mulliken charge to the atoms of mono-substituted pyridines, including both quantum chemical and empirical schemes.
Mahmmoud S. Saieed, Zaheda A. Najim
doaj   +1 more source

Iron-Catalyzed Sulfonylmethylation of Imidazo[1,2-α]pyridines with N,N-Dimethylacetamide and Sodium Sulfinates

Molecules
Functionalized imidazo[1,2-α]pyridines are important scaffolds in pharmaceuticals. Herein, we present an efficient 3-sulfonylmethylation protocol for imidazo[1,2-α]pyridines by sodium sulfinates in DMA and H2O (2:1) via an FeCl3-catalyzed three-component
Shengnan Sun, Hexia Ye, Haibo Liu, Junchen Li, Xiaojing Bi   +4 more
doaj   +1 more source

Synthesis, Molecular Docking Study, and Cytotoxicity Evaluation of Some Novel 1,3,4-Thiadiazole as Well as 1,3-Thiazole Derivatives Bearing a Pyridine Moiety

Molecules, 2022
Pyridine, 1,3,4-thiadiazole, and 1,3-thiazole derivatives have various biological activities, such as antimicrobial, analgesic, anticonvulsant, and antitubercular, as well as other anticipated biological properties, including anticancer activity.
Amr S. Abouzied, Jehan Y. Al-Humaidi, Abdulrahman S Bazaid, Husam Qanash, Naif K. Binsaleh, Abdulwahab Alamri, Sheikh Muhammad Ibrahim, Sobhi M. Gomha   +7 more
doaj   +1 more source

Introduction of the difluoromethyl group at the meta- or para-position of pyridines through regioselectivity switch

Nature Communications
Difluoromethyl pyridines have gained significant attention in medicinal and agricultural chemistry. The direct C−H-difluoromethylation of pyridines represents a highly efficient economic way to access these azines.
Pengwei Xu, Zhe Wang, Shu-Min Guo, Armido Studer   +3 more
doaj   +1 more source

Über 1-Aza-bicyclo-heptane

CHIMIA, 1976
A simple way to synthesize 7-phenyl-1-aza-bicyclo[2,2,1]heptanes out of 4-benzoyl-pyridines is described. The corresponding 3- benzoyl-pyridines did not yield the expected 7-phenyl-1-azabicyclo [3,1,1] heptanes.
A. Marxer
doaj   +1 more source

Electron-Deficient Acetylenes as Three-Modal Adjuvants in S_N^H Reaction of Pyridinoids with Phosphorus Nucleophiles

Molecules, 2021
Publications covering a new easy metal-free functionalization of pyridinoids (pyridines, quinolines, isoquinolines, acridine) under the action of the system of electron-deficient acetylenes (acetylenecarboxylic acid esters, acylacetylenes)/P-nucleophiles
Boris A. Trofimov, Pavel A. Volkov, Anton A. Telezhkin   +2 more
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

New Pyridine Derivatives from Essential Oils

CHIMIA, 1992
Four new pyridines 1–4 have been isolated from jonquil absolute and their structures confirmed by synthesis. These pyridines also occur in other essential oils.
Bruno Maurer, Arnold Hauser
doaj   +2 more sources