Results 11 to 20 of about 36,154 (290)
Trifluoromethylation of pyridines through skeletal rearrangement. [PDF]
Chem SciWe report a skeletal rearrangement of pyridines that enables functionalisation of the 2 and 3-positions, via Zincke ketone intermediates. The ring-opened pyridines undergo selective reaction with cheap and readily available acylating agents, setting up ...
Wang H, Bhaduri N, Greaney MF.
europepmc +6 more sources
Highly enantioselective catalytic synthesis of chiral pyridines [PDF]
Nature Communications, 2017 Chiral pyridines are valuable building blocks in medicinal chemistry applications. Here, the authors report the copper-catalysed Lewis acid-assisted asymmetric alkylation of β-substituted alkenyl pyridines with Grignard reagents affording chiral ...
Ravindra P. Jumde +3 more
doaj +3 more sources
Synthesis of 15N-Pyridines and Higher Mass Isotopologs via Zincke Imine Intermediates [PDF]
, 2023 Methods to incorporate stable radioisotopes are integral to pharmaceutical and agrochemical development. However, despite the prevalence of pyridines in candidate compounds, methods to incorporate 15N-atoms within their structures are limited.
Marie A., Hart +5 more
core +1 more source
Dewar Pyridines: Conformationally Programmable Piperidine Isosteres [PDF]
, 2023 Bioisosteric replacement is an indispensable tool in the medicinal chemist’s arsenal to strike a fine balance in multiparameter optimization campaigns and to deliver the best molecules for further preclinical development.
Jan, Petrovcic +7 more
core +2 more sources
, 2023 The stereoselective preparation of functionalized [1,2,4]triazolo[4,3-a]pyridines from N-tosylhydrazones and pyridines was developed through the dearomatization of pyridines.
Meng Tang (139012) +3 more
core +2 more sources
Simple Bronsted acid catalyzed C-H functionalization: efficient access to poly-substituted pyridines [PDF]
, 2016 An exceptionally simple and environmentally friendly methodology has been developed for directly functionalizing the benzylic C-H bond of the poly-substituted pyridines with aromatic imines.
Zhao, JZ (reprint author), Shanxi Agr Univ Taigu, Coll Art & Sci, Taigu 030800, Shanxi, Peoples R China. +6 more
core +1 more source
, 2022 3-Acyl imidazo[1,5-a]pyridines, featured pharmaceutical moieties that were prepared by a three-step reaction conventionally, could be obtained in one step by an electrochemical tandem sp3 (C–H) double amination of acetophenones with pyridine ...
Lei Ren +9 more
core +2 more sources
Selective Halogenation of Pyridines Using Designed Phosphine Reagents [PDF]
, 2019 Halopyridines are key building blocks for synthesizing pharmaceuticals, agrochemicals, and ligands for metal complexes, but strategies to selectively halogenate pyridine C–H precursors are lacking.
Andrew, McNally +2 more
core +2 more sources
An Efficient Synthesis of Novel Pyrazole-Based Heterocycles as Potential Antitumor Agents
Applied Sciences, 2017 A new series of pyrazolylpyridines was prepared by reaction of ethyl-3-acetyl-1,5-diphenyl-1H-pyrazole-4-carboxylate with the appropriate aldehyde, malononitrile, or ethyl acetoacetate and an excess of ammonium acetate under reflux in acetic acid ...
Magda A. Abdallah +5 more
doaj +1 more source