Results 101 to 110 of about 21,061 (224)

miR‐138‐5p Inhibits Aortic Valve Interstitial by Targeting SLC39A14 and Activating Nrf2 Signaling

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 9, September 2026.
Nrf2 Pathway Inhibition Attenuates miR‐138‐5p's Anti‐Calcification Effects in OM‐Induced hAVICs. A. ALP staining for ALP activity assessment in NC‐mimic, miR‐mimic, and miR‐mimic + ML385 groups. B. Alizarin Red staining for osteogenesis and calcium nIn osteogenic medium‐induced human aortic valve interstitial cells (hAVICs), miR‐138‐5p targets SLC39A14
Fei Yan, Ying Zhao, Yuanyuan Wu, Dubiao Xian, Lei Shi, Yunheng Liang, Ning Wang, Ruiling He, Hongwang Cui, Zhihao Xie   +9 more
wiley   +1 more source

Exploring the Anticancer Activity of Ruthenium(II)–Arene and Copper(I) Complexes Bearing N‐Heterocyclic Carbene Ligands Containing Azido, Pyridinium, and Ethisterone‐Derived Triazole Groups

European Journal of Inorganic Chemistry, Volume 29, Issue 24, 21 August 2026.
A versatile library of backbone‐functionalized N‐heterocyclic carbene (NHC) ligands was developed and efficiently converted into Cu(I) and Ru(II) NHC complexes, demonstrating that ligand functionalization strongly modulates anticancer activity, with Cu(I)–NHC species showing potent and selective antiproliferative effects against ovarian and breast ...
Alessia Schiavo, Chiara Tupini, Nicola Demitri, Ilaria Lampronti, Thomas Scattolin   +4 more
wiley   +1 more source

From Molecules to Materials: The Role of Halogen Bonds in Electron Donor–Acceptor Complex Mediated Organic Synthesis

European Journal of Organic Chemistry, Volume 29, Issue 30, 12 August 2026.
This Concept highlights recent advances in organic synthesis based on electron donor–acceptor (EDA) complex photochemistry, with emphasis on halogen bonding. Halides play a dual role as key components of this noncovalent interaction, and as reactivity‐enabling leaving groups.
Marco Manni, Giacomo Filippini
wiley   +1 more source

Novel cinnamic acid-based <i>N</i>-benzyl pyridinium analogs: potent dual cholinesterase inhibitors with neuroprotective properties for Alzheimer's disease. [PDF]

RSC Adv
Esmkhani M, Mahdavi M, Javanshir S, Iraji A.   +3 more
europepmc   +1 more source

Human Leukocyte Elastase Triggered Nanoparticles for Targeted Antimicrobial Delivery and Oral Microbial Modulation

Advanced NanoBiomed Research, Volume 6, Issue 8, August 2026.
This study explores enzyme‐responsive nanoparticles for targeted antimicrobial release in inflamed oral environments. Nanoparticles formed by complexing peptides and chlorhexidine respond to human leukocyte elastase and release chlorhexidine selectively. P7 (ECAAPVCE)‐based formulations show optimal properties and stability, with antimicrobial activity
Mohammed A. Hadis, Ignacio Insua, Farah N. S. Raja, Álvaro Vila, William M. Palin, Michael R. Milward, Paul R. Cooper, Sarah A. Kuehne, Owen Addison, Paco Fernandez‐Trillo   +9 more
wiley   +1 more source

Selective Reductions of Complex Pyridines via <i>N</i>Tf-Pyridinium Salts. [PDF]

Synthesis (Stuttg)
Josephitis CM, McNally A.
europepmc   +1 more source

Mechanochemistry as an Emerging Tool for Organofluorine Chemistry

Chemistry–Methods, Volume 6, Issue 8, August 2026.
Fluorinated scaffolds are central across many areas of chemistry, driving the demand for efficient and sustainable synthetic methods. Mechanochemistry has emerged as a powerful alternative to conventional approaches, offering reduced environmental impact, shorter reaction times, and unique reactivity and selectivity.
Marie Caldiero, Nicolas Delcroix, Vitalii Solomin, Thomas Castanheiro   +3 more
wiley   +1 more source

Quaternary Carbons from Amines and Acids. [PDF]

J Am Chem Soc
Zhao R, Wang S, Shi P, Das SK, Meng S, Lei A, Cernak T.   +6 more
europepmc   +1 more source

Heart‐Specific Spinal and Vagal Afferents: Transcriptomic Signatures and Optogenetically Modulated Functional Coupling With Cardiomyocytes

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
Selective purification of heart‐specific spinal and vagal sensory neurons by retrograde labeling and FACS purification showed enhanced spontaneous, optogenetic, and chemically stimulated Ca2+ activity. Transcriptomic profiling identified distinct ion channel and GPCR signatures in heart‐specific sensory neurons.
T. Akgul Caglar, Y. E. Kazci, Z. B. Durdu, S. Sahoglu Goktas, S. Bay, E. Vatandaslar, M. U. Turhan, G. Ozturk, E. Cagavi   +8 more
wiley   +1 more source

Isoniazid-derived ionic liquids for enhanced C-steels surface finishing via electrochemistry, supported by Monte Carlo, mechanistic study, theoretical, and docking methodology. [PDF]

Sci Rep
Moustafa AHE, Harfoush AA, Abdel-Rahman HH, Hagar M, Mamdouh M.   +4 more
europepmc   +1 more source