Results 11 to 20 of about 5,613 (180)

A Highly Substituted Ring-Fused 2-Pyridone Compound Targeting PrfA and the Efflux Regulator BrtA in Listeria monocytogenes

mBio, 2023
Listeria monocytogenes is a facultative Gram-positive bacterium that causes listeriosis, a severe foodborne disease. We previously discovered that ring-fused 2-pyridone compounds can decrease virulence factor expression in Listeria by binding and ...
Hasan Tükenmez, Pardeep Singh, Souvik Sarkar, Melike Çakır, Ana H. Oliveira, Cecilia Lindgren, Karolis Vaitkevicius, Mari Bonde, A. Elisabeth Sauer-Eriksson, Fredrik Almqvist, Jörgen Johansson   +10 more
doaj   +1 more source

Inductive Production of the Iron-Chelating 2-Pyridones Benefits the Producing Fungus To Compete for Diverse Niches

mBio, 2021
Diverse 2-pyridone alkaloids have been identified with an array of biological and pharmaceutical activities, including the development of drugs. However, the biosynthetic regulation and chemical ecology of 2-pyridones remain largely elusive.
Bo Chen, Yanlei Sun, Shiqin Li, Ying Yin, Chengshu Wang   +4 more
doaj   +1 more source

Synthesis and Characterization of New 3-Cyano-2-Pyridone Derivatives as Fluorescent Scaffolds

Chemistry Proceedings, 2023
2-pyridones are among the most widely used nitrogen-containing heterocyclic derivatives in various fields due to their structural properties and biological and therapeutic activities.
Asmaa Kebaili, Fatima Belhadj, Zahira Kibou, Julio A. Seijas, M. Pilar Vazquez Tato, Noureddine Choukchou-Braham   +5 more
doaj   +1 more source

The Construction of Polycyclic Pyridones via Ring-Opening Transformations of 3-hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-diones

Molecules, 2023
This work describes the synthesis of 3-hydroxy-3,4-dihydropyrido[2,1-c][1,4]oxazine-1,8-diones, their tautomerism, and reactivity towards binucleophiles. These molecules are novel and convenient building-blocks for the direct construction of biologically
Viktoria V. Viktorova, Elena V. Steparuk, Dmitrii L. Obydennov, Vyacheslav Y. Sosnovskikh   +3 more
doaj   +1 more source

13C- and 1H-NMR substituent-induced chemical shifts in N(1)-(4-substituted phenyl)-3-cyano-4,6-dimethyl-2-pyridones [PDF]

Journal of the Serbian Chemical Society, 2008
The 13C- and 1H-NMR chemical shifts of thirteen N(1)-(4-substituted phenyl)-3-cyano-4,6-dimethyl-2-pyridones were measured in deuterated dimethyl sulfoxide (DMSO-d6). The correlation analysis for the substituent-induced chemical shifts (SCS) with sigmap,
BRATISLAV Z. JOVANOVIC, GORDANA G. USCUMLIC, DUSAN Z. MIJIN, NATASA V. VALENTIC, ALEKSANDAR D. MARINKOVIC   +4 more
doaj   +3 more sources

Recent advances in chemistry and pharmacological aspects of 2-pyridone scaffolds

Journal of Saudi Chemical Society, 2021
Background: The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance.
Mostafa M.K. Amer, Maged A. Aziz, Wesam S. Shehab, Magda H. Abdellattif, Samar M. Mouneir   +4 more
doaj   +1 more source

Reactions of Trifluorotriacetic Acid Lactone and Hexafluorodehydroacetic Acid with Amines: Synthesis of Trifluoromethylated 4-Pyridones and Aminoenones

Molecules, 2022
Dehydroacetic acid and triacetic acid lactone are known to be versatile substrates for the synthesis of a variety of azaheterocycles. However, their fluorinated analogs were poorly described in the literature.
Vladislav V. Fedin, Sergey A. Usachev, Dmitrii L. Obydennov, Vyacheslav Y. Sosnovskikh   +3 more
doaj   +1 more source

The Ring Transformation of 3-Methyl-5-nitropyrimidin-4(3H)-one

Molecules, 2003
3-Methyl-5-nitropyrimidin-4(3H)-one readily reacts with carbonyl compounds to produce three kinds of ring transformations. The nitropyrimidinone behaves as the synthetic equivalent of activated diformylamine affording 3,5-difunctionalized 4-pyridones, 4 ...
Masahiro Ariga, Yasuo Tohda, Kazushige Hori, Mina Tamura, Nagatoshi Nishiwaki   +4 more
doaj   +1 more source

Rapidly Diversifying Hydrogen‐Bonded Organic Frameworks With Permanent Porosity

Angewandte Chemie, EarlyView.
This article reviews diversifying hydrogen‐bonded organic frameworks (HOFs) with permanent porosity reported over the past 15 years, based on the molecular structures of their constituent tectons. Furthermore, several distinctive aspects and concepts are described, such as permanent porosity, isostructural (isoreticular) HOFs, and multicomponent mixed ...
Taito Hashimoto, Ichiro Hisaki
wiley   +2 more sources

Synthesis and investigation of solvent effects on the ultraviolet absorption spectra of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones [PDF]

Journal of the Serbian Chemical Society, 2001
A number of 5-substituted-4-methyl-3-cyano-6-hydroxy-2-pyridones from cyanoacetamide and the corresponding alkyl ethyl acetoacetates were synthesized according to modified literature procedures. The alkyl ethyl acetoacetates were obtained by the reaction
NATASA V. VALENTIC, GORDANA S. USCUMLIC, DUSAN Z. MIJIN   +2 more
doaj   +3 more sources