Results 41 to 50 of about 9,300 (167)

Safety of beta‐nicotinamide mononucleotide (β‐NMN) pursuant the regulation (EU) 2015/2283 and the bioavailability of nicotinamide from this source in the context of Directive 2002/46/EC

EFSA Journal, Volume 24, Issue 5, May 2026.
Abstract Following a request from the European Commission, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on beta‐nicotinamide mononucleotide (β‐NMN) as a novel food (NF) pursuant to Regulation (EU) 2015/2283, including an evaluation of the safety of its use in food supplements as a source of niacin ...
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Ángeles Jos, Alexandre Maciuk, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Margarita Aguilera‐Gómez, Francesco Cubadda, Thomas Frenzel, Ursula Gundert‐Remy, Francesca Marcon, Harry J. McArdle, Monika Neuhäuser‐Berthold, Miguel Prieto Maradona, Alexandros Siskos, Matthew Wright, Elisa Beneventi, Annamaria Rossi, Maura Magani, Karen Ildico Hirsch‐Ernst   +28 more
wiley   +1 more source

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, Volume 32, Issue 13, 1 April 2026.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Non‐redox Lewis Acids Supported Pd‐Catalyzed C—C /C—H Activation and Accession to Produce Pharmaceutical Intermediates

ChemistryOpen, Volume 15, Issue 4, April 2026.
Palladium is a simple and versatile redox‐active metal that plays a crucial role in the oxidation reactions for organic synthesis and production of pharmaceutical intermediates. Notably, there has been significant progress with Lewis acids (LAs), which are non‐redox metal ions promoting Pd(II)‐catalyzed oxidation via C—H and C—C bond activation.
Ahmed M. Senan, Senem Akkoc, A. M. Abdulkarem, Sadeq K. Alhag   +3 more
wiley   +1 more source

New paradigms for understanding and step changes in treating active and chronic, persistent apicomplexan infections [PDF]

, 2016
Toxoplasma gondii, the most common parasitic infection of human brain and eye, persists across lifetimes, can progressively damage sight, and is currently incurable. New, curative medicines are needed urgently.
Alibana-Clouser, F, Antonyuk, SV, Brasseur, G, Capper, M, Donkin, D, Dovgin, S, Dubey, J, El Bissatai, K, Esaa, F, Fishwick, CWG, Fraczek, L, Gordon, J, Hasnain, S, He, Y, Hickman, M, Hood, L, Kent, M, Kim, E, Kim, TK, Lee, P, Lorenzi, H, Lukens, AK, Lykins, J, McLeod, R, McPhillie, M, Meunieur, B, Moulton, H, Muench, S, Roberts, CW, Sanders, J, Santos, T, Verma, SK, Wang, K, Weber, CR, Weiss, L, Wheeler, K, Wirth, D, Woods, S, Zhou, Y   +38 more
core   +4 more sources

Asymmetric Negishi and Kumada Couplings

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
This review summarizes asymmetric Negishi and Kumada cross‐coupling reactions from the 1980s through 2025. It examines enantioselective and enantiospecific transformations catalyzed by nickel, palladium, and cobalt complexes , highlighting ligand design, mechanistic insights, and applications in constructing complex chiral molecules and natural ...
Rui‐Heng Wang, Aishun Ding, Ramon Rios
wiley   +1 more source

Evaluation of chemical compounds for induction of male sterility in wheat (Triticum aestivum L.) [PDF]

, 2006
The short-list of eleven chemical hybridizing agents (CHAs) showing 98% or more induction of male sterility were identified following application at the pre-meiotic stage of wheat.
Chakraborty, Kajal, Devakumar, C
core  

Ordered and ushered; the assembly and translocation of the adhesive Type I and P Pili [PDF]

, 2013
Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit ...
Aberg, Bouckaert, Chorell, Clarke, Cusumano, Di Yu, Huang, Klinth, Larsson, Leney, Lindberg, Lo, Mapingire, Morrissey, Nuccio, Phan, Schilling, Ulett, Wallden, Zhang   +19 more
core   +2 more sources

Dinuclear Rhodium(I)–N‐Heterocyclic Carbene Complexes as Alkyne Hydropyridonation Catalysts

European Journal of Inorganic Chemistry, Volume 29, Issue 7, 2 March 2026.
Catalyst Improvement by NHC tuning: A series of new RhI–NHC dinuclear complexes has been revealed as efficient alkyne hydropyridonation catalysts. 333053IMes complex displays the highest reactivity of the series, suggesting that a moderate steric demand combined with balanced σ‐donation facilitates precatalyst activation and substrate exchange.
Belinda Español‐Sánchez, Mert Olgun Karataş, Andrea Di Giuseppe, Ulugbek Togaev, Vincenzo Passarelli, Luis A. Oro, Jesús J. Pérez‐Torrente, Ricardo Castarlenas   +7 more
wiley   +1 more source

Targeting cancer cell mitochondria with a multivalent source of singlet oxygen

Smart Molecules, Volume 4, Issue 1, March 2026.
Multivalent source of singlet oxygen can effectively target cancer cell mitochondria and cause improved cancer cell selective cytotoxicity at low micromolar concentrations. Abstract Naphthalene, anthracene and pyridone endoperoxides are known to thermally release singlet oxygen.
Wanwan Wang, Lei Wang, Rensong Sun, Shoucai Yan, Engin U. Akkaya   +4 more
wiley   +1 more source

New approach to condensed pyrid-2-ones [PDF]

, 2002
We wish to report a simple procedure for the preparation of 5-substituted-thienopyridin-7-ones and 7-substituted-1,6-naphthyridin-5(6H)-ones, in good yields, from the dianions of 3-methylthiophene-2-carboxylic and 2-methylnicotinic acids on treatment ...
Brun Sanchez, Eva Maria, Gil Grau, Salvador, Parra Alvarez, Margarita   +2 more
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