Results 51 to 60 of about 7,788 (207)

Binuclear Copper‐Dependent Oxidative Enzymes Involved in Fungal Natural Product Modifications

Journal of the Chinese Chemical Society, EarlyView.
This article summarizes recent biochemical characterizations of a new enzyme family named by the authors as binuclear copper‐dependent oxidative enzymes (BiNCOs). Found in fungal natural product biosynthesis, BiNCOs catalyze diverse CH functionalization reactions, including C(sp3)H halogenation, C(sp3)H hydroxylation, C(sp3)O macrocyclization, and ...
Chen‐Yu Chiang, Masao Ohashi, Yi Tang
wiley   +1 more source

Microwave-Assisted Synthesis and Functionalization of 2-Pyridones, 2-Quinolones and Other Ring-Fused 2-Pyridones

, 2006
2-pyridones are important heterocycles with great applicability in medicinal chemistry and this core structure can be found in compounds with various biological/medicinal applications.
Nils Pemberton, Pemberton, Nils,, Fredrik Almqvist, Chorell, Erik,, Almqvist, Fredrik,, Erik Chorell   +5 more
core   +1 more source

Gold(I)‐Catalyzed Annulation of Pyridines Containing Alkyne: Synthesis of N‐Alkenyl Pyridonyl Azides via Rearrangement

Journal of Heterocyclic Chemistry, EarlyView.
One‐pot gold(I)‐catalysts synthesis was developed in order to prepare N‐alkenyl 2‐pyridonyl azides. This method provides a series of N‐alkenyl 2‐pyridonyl azides in moderate to excellent yields (up to 94%). ABSTRACT A novel strategy, involving the preparation of gold‐catalyzed cyclization salts and the rearrangement of these salts in the presence of ...
Ali Osman Karatavuk
wiley   +1 more source

All‐in‐One Interface Engineering From Bulk to Electrode Toward High‐Performance Micro‐Sized Silicon Anodes

Small, EarlyView.
Microsized silicon (µ‐Si, >1 µm) is one of the ideal anodes for lithium‐ion batteries. In this paper, an integrated co‐carbonization electrode (ICCE) without binder and conductive agent was prepared by precoating a uniform carbon layer on the surface of µ‐Si particles, which significantly improved the electrochemical performance.
Shuqi Wang, Lingxiao Xue, Chengzhi Zhang, Fei Wang, Zhendong Liu, Ziyi Shao, Shun Zhang, Hong‐Bin Sun, Zhenhuai Yang, Quanbing Liu, Xinwen Peng   +10 more
wiley   +1 more source

General Method for the Preparation of Substituted 2-Amino-4H,5H-pyrano[4,3-b]pyran-5-ones and 2-Amino-4H-pyrano[3,2-c]pyridine-5-ones

Molecules, 2000
Reaction of 4-hydroxy-6-methyl-2-pyrone (1a) as well as 4-hydroxy-6-methyl-2(1H)-pyridones (1b-d) with arylmethylene malononitriles or arylmethylene methyl cyanoacetates (2a-h) leads to the formation of the very stable 5,6-fused bicyclic 2-amino-4Hpyran ...
Dieter Heber, Ivo C. Ivanov, Edmont V. Stoyanov   +2 more
doaj   +1 more source

Alkoxyallenes in Modern Synthesis: Reactivity, Catalysis, and Complexity Generation

Advanced Synthesis &Catalysis, Volume 368, Issue 17, 1 September 2026.
The last decade has witnessed a remarkable transformation in alkoxyallene chemistry. Although historically employed as synthetic equivalents of acrolein or as versatile 3C synthons, alkoxyallenes are now increasingly recognized as highly adaptable platforms for synthetic design.
A. Lanfranco, M. Rusconi, J. Saglietto, P. Renzi, A. Deagostino, E. Azzi   +5 more
wiley   +1 more source

Studies on 4-Pyrones and 4-Pyridones. I. The Preparation of 1-Aryl-3-hydroxy-4-pyridones and Related Compounds [PDF]

, 1961
By condensation rnf meconic acid, comenic acid, or comenic acid methyl ether with primary aromatic amines, 1-aryl-5-hydroxy-4- -pyridone-2-carboxylic acids, or their methyl ethers, were obtained with satisfactory yields.
Hahn, V., Kukolja, S.
core   +1 more source

DIELS-ALDER ADDITION OF BENZYNE TO N-SUBSTITUTED 2-PYRIDONES.

, 1971
DIELS-ALDER ADDITION OF BENZYNE TO N-SUBSTITUTED 2 ...
ERIC BENJAMIN. SHEININ (7996424)
core   +5 more sources

Avoiding pitfalls when modelling ligands in macromolecular crystallography

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1016-1029, September 2026.
Flawed protein–ligand X‐ray structures can misdirect drug discovery based on PDB‐deposited models. This review uses publicly available PDB examples to highlight potential pitfalls, from absent ligands to incorrect chemistry, and presents a practical validation approach to improve model reliability.The determination of protein–ligand complex structures ...
Oliver S. Smart, Andrew Sharff, Claus Flensburg, Clemens Vonrhein, Gérard Bricogne   +4 more
wiley   +1 more source

Metal-Free Cascade Formation of C–C and C–N Bond for the Construction of 3-Cyano-2-Pyridones with Insecticidal Properties

Molecules
A straightforward and efficient methodology has been developed for the synthesis of 3-cyano-2-pyridones via the C–C and C–N bond formation processes. A total of 51 diverse 3-cyano-2-pyridone derivatives were obtained in moderate to excellent yields. This
Yao Tang, Nvjiang Wu, Junyu Xu, Xiaopo Zhang, Youbin Li, Xuesong Wang   +5 more
doaj   +1 more source