Results 71 to 80 of about 9,300 (167)

Targeting virulence not viability in the search for future antibacterials [PDF]

, 2014
New antibacterials need new approaches to overcome the problem of rapid antibiotic resistance. Here we review the development of potential new antibacterial drugs that do not kill bacteria or inhibit their growth, but combat disease instead by targeting ...
Aberg, Arnon, Babcock, Bader, Bardwell, Bardwell, Bebbington, Bouckaert, Busch, Cegelski, Cegelski, Chan, Chatterjee, Chorell, Dailey, Duncan, Enquist, Escaich, Felise, Fruh, Garcia-Contreras, Ha, Hentzer, Heras, Hirakawa, Hu, Hu, Hung, Inaba, Infectious Disease Society of America, Ireland, Jacob-Dubuisson, Jang, Jubb, Keller, LaSarre, Lazar, Maeda, Maresso, Miki, Miller, Mitchell, Miyairi, Mohamed, Morkunas, Ochsner, Peek, Piatek, Pinkner, Qin, Rasko, Rasmussen, Riddle, Romero, Russell, Sarkar-Tyson, Schmitt, Sheoran, Sintim, Slepenkin, Stenson, Stevens, Subramanian, Suree, Suree, Tay, Tinsley, Tomb, Totsika, Totsika, Touaibia, Ur-Rehman, Vitale, Watarai, Wolf, Zhang, Zhu, Zucca   +77 more
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A flexible radical approach to 5-substituted 4,5-dihydro-3H-pyrido[4,3-b]azepin-2-ones. Some mechanistic observations on the radical cyclisation-aromatisation process

, 2012
International audienceVariously substituted novel dihydropyridoazepinones have been prepared by an intermolecular radical addition followed by a radical cyclisation on a pyridine ring. The latter process involved the use of a combination of two different
Botez, I., Petit, Laurent, Tizot, A., Zard, Samir,   +3 more
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Pharmacological treatments for Friedreich ataxia [PDF]

, 2016
BACKGROUND: Friedreich ataxia is a rare inherited autosomal recessive neurological disorder, characterised initially by unsteadiness in standing and walking, slowly progressing to wheelchair dependency usually in the late teens or early twenties.
Brassington, R, Fahey, M, Kearney, M, Orrell, RW, Pandolfo, M   +4 more
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Design, Synthesis and Anti-HIV Integrase Evaluation of 4-Oxo-4H-quinolizine-3-carboxylic Acid Derivatives [PDF]

, 2009
4-Oxo-4H-quinolizine-3-carboxylic acid derivatives bearing sulfamido, carboxylamido, benzimidazole and benzothiazole substituents have been designed and synthesized. The structures of these new compounds were confirmed by 1H-NMR, 13C- NMR, IR and ESI (or
Brown, Cheng-Chu Zeng, Fukumoto, Iwamoto, Kawasuji, Li, Li-Ming Hu, Molla, Oya, Ru-gang Zhong, Yi-Sheng Xu, Zeng, Zi-Guo Jiao   +12 more
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Assessing Risk and Return: Personalized Medicine Development & New Innovation Paradigm [PDF]

, 2008
Outlines how focusing on subpopulations with biomarkers could make the pre-clinical and clinical phases of drug innovation more efficient and create economic returns.
Frank L. Douglas, Lesa Mitchell
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Antimicrobial and antioxidative activities of 1-adamantylthio derivatives of 3-substituted pyridines [PDF]

, 2008
Diverse biological activities of sulfur containing pyridines were reported. To investigate for new lead compounds, thus, 1-adamantylthiopyridines bearing 3-substituents (OEt, OAc, NAc2, Br and OH) were prepared and evaluated for antimicrobial and ...
Isarankura-Na-Ayudhya, Chartchalerm, Prachayasittikul, Supaluk, Prachayasittikul, Virapong, Ruchirawat, Somsak, Suksrichavalit, Thummaruk   +4 more
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Concise Entries to 4-Halo- and 3-Bromo-4-halo-2-pyridones [PDF]

, 2016
Gallagher, Timothy, Honraedt, Aurelien
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Efeito do extrato aquoso de leucena sobre o desenvolvimento, índice mitótico e atividade de peroxidase em plântulas de milho. [PDF]

, 2018
A leucena (Leucaena leucocephala (Lam.) de Wit), quando usada como cobertura no solo, apresenta a propriedades de controlar plantas daninhas, sendo esse efeito resultante da presença de aleloquímicos, principalmente mimosina, encontrados na parte aérea ...
FARIA, T. C. L. de, MAGALHAES, P. C., PEREIRA FILHO, I. A., PIRES, N. de M., PRATES, H. T., SOUZA, I. R. P.   +5 more
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Positive Allosteric Modulators for mGluR2 Receptors: A Medicinal Chemistry Perspective [PDF]

, 2014
Keserű, György Miklós, Szabó, György   +1 more
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Tautomeric Equilibria Studies by Mass Spectrometry [PDF]

, 2008
Tautomerism in organic chemistry has been extensively studied in condensed phase by spectrometric methods, mainly by IR and NMR techniques. Mass spectrometry studies start 40 years ago but just recently it has been recognized the importance of the mass ...
Eduardo A. Castro, Jorge J. Furlong, Mercedes M. Schiavonni, Patricia E. Allegretti   +3 more
core   +1 more source