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Clinica Chimica Acta, 2017
We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in paired serum and cerebrospinal fluid (CSF) samples from children and investigated the effect of age on the concentrations and CSF-to-serum ratios of these vitamers.Serum and CSF samples prospectively collected from 49 pediatric patients were analyzed.
Tomoyuki Akiyama +7 more
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We quantified pyridoxal 5'-phosphate (PLP), pyridoxal (PL), and 4-pyridoxic acid (PA) in paired serum and cerebrospinal fluid (CSF) samples from children and investigated the effect of age on the concentrations and CSF-to-serum ratios of these vitamers.Serum and CSF samples prospectively collected from 49 pediatric patients were analyzed.
Tomoyuki Akiyama +7 more
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Annals of the New York Academy of Sciences, 1990
Chymotryptic digestion of sheep brain pyridoxal kinase, a dimer of identical subunits each of 40 kDa, yields two fragments of 24 and 16 kDa with concomitant loss of catalytic activity. These fragments were separated by HPLC and used for binding studies with ATP and pyridoxal analogues.
J E, Churchich, Y T, Kim
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Chymotryptic digestion of sheep brain pyridoxal kinase, a dimer of identical subunits each of 40 kDa, yields two fragments of 24 and 16 kDa with concomitant loss of catalytic activity. These fragments were separated by HPLC and used for binding studies with ATP and pyridoxal analogues.
J E, Churchich, Y T, Kim
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Efficacy and safety of pyridoxal in West syndrome: A retrospective study.
Brain & development (Tokyo. 1979), 2019OBJECTIVE To evaluate the efficacy and safety of pyridoxal for treating West syndrome. METHODS We retrospectively investigated pyridoxal's efficacy and safety in 117 patients with West syndrome at Saitama Children's Medical Center from July 1993 to May
Ryuki Matsuura +6 more
semanticscholar +1 more source
Reaction of dithionite and bisulfite with pyridoxal and pyridoxal enzymes
Analytical Biochemistry, 1969Abstract Both bisulfite and dithionite produce marked changes in the spectra of pyridoxal, pyridoxal phosphate, and pyridoxal phosphate enzymes. The spectrum of pyridoxal phosphate in bisulfite solutions resembles that of the addition product of pyridoxal phosphate with cysteine.
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Direct polarographic determination of pyridoxal in the presence of pyridoxal-5-phosphate
Collection of Czechoslovak Chemical Communications, 1962The determination of pyridoxal in the presence of pyridoxal-5-phosphate may be1 based on the difference between the total wave-height obtained at pH about 9, where both substances give a diffusion-controlled wave and that obtained in acid media, where pyridoxal alone shows a kinetic current2.
O. Manoušek, P. Zuman
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Pyridoxal-specific antibodies obtained with a synthetic pyridoxal-polypeptide conjugate
Biochimica et Biophysica Acta (BBA) - General Subjects, 1966Abstract The attachment of pyridoxal to a non-antigenic synthetic branched polypeptide resulted in an immunogenic macromolecule, capable of eliciting in rabbits antibodies with specificity directed against the pyridoxal moiety. The anti-pyridoxal antibodies were purified immunospecifically, making use of ion-exchange chromatography in 8 M urea.
H, Ungar-Waron, M, Sela
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Luminescence spectroscopy of pyridoxic acid and pyridoxic acid bound to proteins
European Journal of Biochemistry, 1994Luminescence techniques, i.e. fluorescence and phosphorescence, have been employed to study pyridoxic acid bound to proteins through a stable amide linkage. Proteins tagged with 4‐pyridoxic acid display the following fluorescence properties: (a) emission and excitation spectra centered at around 430 and 320 nm, respectively; (b) fluorescence quantum ...
O S, Kwon, M, Blazquez, J E, Churchich
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Pyridoxal Derivatives in Transamination
Nature, 1952IN living systems a transfer of amino groups occurs between certain amino-acids and keto-acids. This important reversible process, known as ‘transamination’1, effects a link between carbohydrate and protein metabolism, and the responsible enzymes, the transaminases, are activated by pyridoxal2 or pyridoxamine phosphates3. The proposed mechanisms of the
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Transport and Metabolism of Pyridoxal and Pyridoxal Phosphate in the Small Intestine of the Rat
The Journal of Nutrition, 1979The vascularly perfused small intestine of the rat was utilized to study the absorption and metabolism of pyridoxamine (PM) and pyridoxamine-5'-phosphate (PMP), independent of other tissues including erythrocytes. [3H]PM or [3H]PMP was administered intralumenally with or without the addition of unlabeled PM, or PMP or inorganic phosphate.
H, Mehansho, M W, Hamm, L M, Henderson
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Neuroprotective Effects of Pyridoxal Phosphate and Pyridoxal against Ischemia in Monkeys
Nutritional Neuroscience, 2001Previously, in monkeys undergoing 20 min whole brain ischemia we demonstrated that the activated calpain-induced lysosomal disruption with the resultant leakage of cathepsins B and L, causes neuronal death in the cornu Ammonis (CA) 1 sector on day 5.
T, Yamashima +4 more
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