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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2015 Pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B6, plays a crucial role in several cellular processes. In most organisms, PLP is recycled from nutrients and degraded B6-enzymes in a salvage pathway that involves pyridoxal kinase (PLK), pyridoxine phosphate oxidase and phosphatase activities.
DI SALVO, Martino Luigi +6 more
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Pyridoxal-5′-phosphate and pyridoxal biokinetics in aging Wistar rats
Experimental Gerontology, 1991 Biokinetic parameters of plasma pyridoxal-5'-phosphate (PLP) and pyridoxal (PL) disposition were studied in male Wistar rats aged 8 and 27 months kept from weaning on a purified diet containing 250 g casein and 6 mg pyridoxine.HCl per kg. Baseline plasma PLP concentration was lower in the older animals (514 +/- 56 nmol/L for young and 317 +/- 124 nmol ...
Bode, W., Berg, H. van den
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Pyridoxal phosphate-dependent enzymes
BBA - Proteins and Proteomics, 1995R A John
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Fluorometric assay of pyridoxal and pyridoxal 5′-phosphate
Analytical Biochemistry, 1979Abstract A new and very sensitive fluorometric method for the determination of pyridoxal and pyridoxal 5′-phosphate is reported. The specificity is based on the reductive amination of pyridoxal and its 5′-phosphate with methyl anthranilate and sodium cyanoborohydride at pH 4,5 to 5,0.
M S, Chauhan, K, Dakshinamurti
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Inhibition of gaba binding by pyridoxal and pyridoxal phosphate
International Journal of Biochemistry, 1980Abstract 1. 1. GABA exerts its neuroinhibitory effects by binding to a specific receptor on the post-synaptic membrane. 2. 2. Since both GABA and vitamin B 6 have been implicated in convulsion, the effects of B 6 vitamers on Na-independent binding of GABA was investigated by incubating synaptic membrane suspensions for 5 min at 4°C in 1 ml ...
M, Ebadi, B, Klangkalya, J D, Deupree
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Biomedical aspects of pyridoxal 5 -phosphate availability
Frontiers in Bioscience - Elite, 2012 The biologically active form of vitamin B6, pyridoxal 5'-phosphate (PLP), is a cofactor in over 160 enzyme activities involved in a number of metabolic pathways, including neurotransmitter synthesis and degradation.
Roberto Contestabile, Martin Safo
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DRUG-PYRIDOXAL PHOSPHATE INTERACTIONS
Drug Metabolism and Drug Interactions, 1982In this review it has been pointed out that vitamin B6 and its vitamers can be involved in many interactions with a number of drugs, as well as with the actions of various endocrines and neurotransmitters. Nutritional deficiencies, especially of vitamins and proteins, can affect the manner in which drugs undergo biotransformation, and thereby may also ...
M, Ebadi, C F, Gessert, A, Al-Sayegh
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The interactions between biogenic amines and pyridoxal, pyridoxal phosphate, and pyridoxal kinase
Archives of Biochemistry and Biophysics, 1972Abstract The effect of biogenic amines on pyridoxal kinase activity has been investigated in vitro . Experiments with a purified beef brain pyridoxal kinase indicate that 3,4-dihydroxyphenylalanine (dopa), dopamine, norepinephrine, and serotonin inhibit the reaction, while tyrosine, tryptophan, and 5-hydroxytryptophan (5-HTP) have no effect. However,
J T, Neary +3 more
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Direct polarographic determination of pyridoxal in the presence of pyridoxal-5-phosphate
Collection of Czechoslovak Chemical Communications, 1962The determination of pyridoxal in the presence of pyridoxal-5-phosphate may be1 based on the difference between the total wave-height obtained at pH about 9, where both substances give a diffusion-controlled wave and that obtained in acid media, where pyridoxal alone shows a kinetic current2.
O. Manoušek, P. Zuman
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Transport and Metabolism of Pyridoxal and Pyridoxal Phosphate in the Small Intestine of the Rat
The Journal of Nutrition, 1979The vascularly perfused small intestine of the rat was utilized to study the absorption and metabolism of pyridoxamine (PM) and pyridoxamine-5'-phosphate (PMP), independent of other tissues including erythrocytes. [3H]PM or [3H]PMP was administered intralumenally with or without the addition of unlabeled PM, or PMP or inorganic phosphate.
H, Mehansho, M W, Hamm, L M, Henderson
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