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Safety and efficacy of long term asfotase alfa treatment in childhood hypophosphatasia. [PDF]

open access: yesItal J Pediatr
d'Angelo DM   +10 more
europepmc   +1 more source
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On the mechanism of Escherichia coli pyridoxal kinase inhibition by pyridoxal and pyridoxal 5′-phosphate

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2015
Pyridoxal 5'-phosphate (PLP), the catalytically active form of vitamin B6, plays a crucial role in several cellular processes. In most organisms, PLP is recycled from nutrients and degraded B6-enzymes in a salvage pathway that involves pyridoxal kinase (PLK), pyridoxine phosphate oxidase and phosphatase activities.
DI SALVO, Martino Luigi   +6 more
openaire   +4 more sources

Pyridoxal phosphate: Biosynthesis and catabolism

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2011
Vitamin B(6) is an essential cofactor that participates in a large number of biochemical reactions. Pyridoxal phosphate is biosynthesized de novo by two different pathways (the DXP dependent pathway and the R5P pathway) and can also be salvaged from the environment.
Mukherjee, Tathagata   +4 more
openaire   +4 more sources

An evaluation of the effects of pyridoxal phosphate in chlorpromazine-induced Parkinsonism using mice.

Central Nervous System Agents in Medicinal Chemistry, 2020
BACKGROUND Parkinsonism is a neurodegenerative disorder with a heavy disease burden, despite the discovery and application of drugs. Current research is beginning to suggest the possible crucial roles of micronutrients such as pyridoxal phosphate in the ...
A. Olofinnade   +6 more
semanticscholar   +1 more source

Fluorometric assay of pyridoxal and pyridoxal 5′-phosphate

Analytical Biochemistry, 1979
Abstract A new and very sensitive fluorometric method for the determination of pyridoxal and pyridoxal 5′-phosphate is reported. The specificity is based on the reductive amination of pyridoxal and its 5′-phosphate with methyl anthranilate and sodium cyanoborohydride at pH 4,5 to 5,0.
K. Dakshinamurti, M.S. Chauhan
openaire   +3 more sources

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